Exploring Paternal Involvement from Greek, Greek - Cypriot and Turkish Fathers’ and Mothers’ Perspectives: Cross-National Differences and Similarities

Although European fatherhood is “in the process of reconstruction and transformation” (O’Brien 2004, as cited in Lero, Ashbourne and Whitehead 2006, 5) and there is a need to create a clear picture about paternal involvement, few studies have explored perceptions on the actual father involvement as well as the factors predicting and relating to father involvement, especially in Southeastern European countries. The present study aims at exploring the role of the father and the types of paternal involvement in Greece, Cyprus and Turkey both from mother’s and fathers’ perspectives. Research results revealed statistically significant differences in terms of the role of the father and the parental styles adopted in a country level and in the way fathers are involved in a parent level. Further, results confirm the hypothesis that father involvement is a multidimensional concept since statistically significant correlations were revealed among scales and subscales

Exploring Paternal Involvement from Greek, Greek - Cypriot and Turkish Fathers’ and Mothers’ Perspectives: Cross-National Differences and Similarities

Although European fatherhood is “in the process of reconstruction and transformation” (O’Brien 2004, as cited in Lero, Ashbourne and Whitehead 2006, 5) and there is a need to create a clear picture about paternal involvement, few studies have explored perceptions on the actual father involvement as well as the factors predicting and relating to father involvement, especially in Southeastern European countries. The present study aims at exploring the role of the father and the types of paternal involvement in Greece, Cyprus and Turkey both from mother’s and fathers’ perspectives. Research results revealed statistically significant differences in terms of the role of the father and the parental styles adopted in a country level and in the way fathers are involved in a parent level. Further, results confirm the hypothesis that father involvement is a multidimensional concept since statistically significant correlations were revealed among scales and subscales

Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma

Our aim was to determine the prevalence, prognostic and predictive role of germline pathogenic/likely pathogenic variants (P/LPVs) in cancer predisposing genes in patients with pancreatic ductal adenocarcinoma (PDAC). Germline testing of 62 cancer susceptibility genes was performed on unselected patients diagnosed from 02/2003 to 01/2020 with PDAC, treated at Hellenic Cooperative Oncology Group (HeCOG)-affiliated Centers. The main endpoints were prevalence of P/LPVs and overall survival (OS). P/LPVs in PDAC-associated and homologous recombination repair (HRR) genes were identified in 22 (4.0%) and 42 (7.7%) of 549 patients, respectively. P/LPVs were identified in 16 genes, including ATM (11, 2.0%) and BRCA2 (6, 1.1%), while 19 patients (3.5%) were heterozygotes for MUTYH P/LPVs and 9 (1.6%) carried the low-risk allele, CHEK2 p.(Ile157Thr). Patients carrying P/LPVs had improved OS compared to non-carriers (22.6 vs. 13.9 months, p = 0.006). In multivariate analysis, there was a trend for improved OS in P/LPV carriers (p = 0.063). The interaction term between platinum exposure and mutational status of HRR genes was not significant (p-value = 0.35). A significant proportion of patients with PDAC carries clinically relevant germline P/LPVs, irrespectively of age, family history or disease stage. The predictive role of these P/LPVs has yet to be defined. ClinicalTrials.gov Identifier: NCT03982446