Sensitive Long-Indel-Aware Alignment of Sequencing Reads

The tremdendous advances in high-throughput sequencing technologies have made population-scale sequencing as performed in the 1000 Genomes project and the Genome of the Netherlands project possible. Next-generation sequencing has allowed genom-wide discovery of variations beyond single-nucleotide polymorphisms (SNPs), in particular of structural variations (SVs) like deletions, insertions, duplications, translocations, inversions, and even more complex rearrangements. Here, we design a read aligner with special emphasis on the following properties: (1) high sensitivity, i.e. find all (reasonable) alignments; (2) ability to find (long) indels; (3) statistically sound alignment scores; and (4) runtime fast enough to be applied to whole genome data. We compare performance to BWA, bowtie2, stampy and find that our methods is especially advantageous on reads containing larger indels

The Hazard of Merger by Absorption – Why Some Knappschaften Merged and Others Did not: 1861–1920

By the mid-19th century, following the Prussian mining reform, German miners‘ combined mutual health and pension funds took on the characteristics of social insurance and underwent a concentration process driven by mergers, liquidations, and unequal internal growth. This paper investigates the determinants of mergers by absorption among Prussian funds combined with quantitative evidence from a regression model, provides new insights into the first social-insurance merger wave in Germany. While most contemporary sources convey the impression that funds were merged to stabilize the entire insurance scheme by sorting out actuarially unviable and financially distressed funds, statistical evidence suggests that funds were absorbed over time primarily because they offered advantages to the absorbing fund and, hence, were quite attractive targets.Competing risk; financial distress; insurance; Knappschaft; liquidation; merger; mining

Overvalued: Swedish Monetary Policy in the 1930s

This paper reconsiders the role of monetary policy in Sweden’s strong recovery from the Great Depression. The Riksbank in the 1930s is sometimes seen as an example of a central bank that was relatively innovative in terms of the conduct of monetary policy. To consider this analytically, we estimate a small-scale, structural general equilibrium model of a small open economy using Bayesian methods. We find that the model captures the key dynamics of the period surprisingly well. Importantly, our findings suggest that Sweden avoided the worst excesses of the depression by conducting conservative rather than innovative monetary policy. We find that, by keeping the Swedish krona undervalued to replenish foreign reserves, Sweden’s exchange rate policy unintentionally contributed to the Swedish growth miracle of the 1930s, avoiding a major slump in 1932 and enabling the country to benefit quickly from the eventual recovery of world demand.

Electroweak precision for W+jet production

In this talk we discuss the next-to-leading-order electroweak (EW) corrections to W-boson + jet hadroproduction [1] and compare the full result to a simple approximation assuming factorization of EW and QCD corrections for the charged-current Drell-Yan process. The W-boson resonance is treated consistently using the complex-mass scheme, and all off-shell effects are taken into account. The corresponding next-to-leading-order QCD corrections have also been recalculated. All the results are implemented in a flexible Monte Carlo code. Selected numerical results for this Standard Model benchmark process are presented for the LHC. The comparison of our result to an approximation based on the EW corrections to W-boson production without additional jets is a step towards a better understanding of the interplay between QCD and EW effects for W-boson production in general.Comment: 6+1 pages, contribution to the proceedings of the 9th International Symposium on Radiative Corrections (RADCOR 2009), October 25-30 2009, Ascona, Switzerlan

A minimal model of many body localization

We present a fully analytical description of a many body localization (MBL) transition in a microscopically defined model. Its Hamiltonian is the sum of one- and two-body operators, where both contributions obey a maximum-entropy principle and have no symmetries except hermiticity (not even particle number conservation). These two criteria paraphrase that our system is a variant of the Sachdev-Ye-Kitaev (SYK) model. We will demonstrate how this simple `zero-dimensional' system displays numerous features seen in more complex realizations of MBL. Specifically, it shows a transition between an ergodic and a localized phase, and non-trivial wave function statistics indicating the presence of `non-ergodic extended states'. We check our analytical description of these phenomena by parameter free comparison to high performance numerics for systems of up to $N=15$ fermions. In this way, our study becomes a testbed for concepts of high-dimensional quantum localization, previously applied to synthetic systems such as Cayley trees or random regular graphs. We believe that this is the first many body system for which an effective theory is derived and solved from first principles. The hope is that the novel analytical concepts developed in this study may become a stepping stone for the description of MBL in more complex systems.Comment: 21 pages, 8 figures, introduction rewritten, changed titl

Electroweak corrections to dilepton + jet production at hadron colliders

The first calculation of the next-to-leading-order electroweak corrections to Z-boson + jet hadroproduction including leptonic Z-boson decays is presented, i.e. to the production of a charged lepton--anti-lepton final state in association with one hard jet at the LHC and the Tevatron. The Z-boson resonance is treated consistently using the complex-mass scheme, and all off-shell effects as well as the contributions of the intermediate photon are taken into account. The corresponding next-to-leading-order QCD corrections have also been recalculated. The full calculation is implemented in a flexible Monte Carlo code. Numerical results for cross sections and distributions of this Standard Model benchmark process are presented for the Tevatron and the LHC.Comment: 32 pages, 13 figures. v2, further phenomenological results included, version published in JHE