9 research outputs found
Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments
A proof
of concept for the combination of an asymmetric organocatalytic
reaction with a biotransformation toward a “one-pot like”
process for 1,3-diols based on immobilized organo- and biocatalysts,
which are utilized in different compartments, is demonstrated. This
process which runs completely in organic media consists of an initial
proline-derivative-catalyzed aldol reaction and a subsequent reduction
of the aldol adduct catalyzed by an alcohol dehydrogenase (ADH) without
the need for intermediate isolation. Economically attractive superabsorber-based
coimmobilization for the ADH and its cofactor NAD<sup>+</sup> turned
out to give a highly efficient biocatalyst with excellent reusability
and simple product separation from the immobilizate under avoidance
of any tedious extraction steps during the overall process
TEFDDOLs (α,α,α′,α′-Tetrakis(perfluoroaryl/alkyl)-2,2′-dimethyl-1,3-dioxolane-4,5-dimethanols): Highly Fluorinated Chiral H‑Bond Donors and Brønsted Acids with Distinct H‑Bonding Patterns and Supramolecular Architectures
The synthesis of six enantiopure α,α,α′,α′-tetrakis(perfluoroalkyl/aryl)-2,2′-dimethyl-1,3-dioxolane-4,5-dimethanols
(TEFDDOLs), by addition of perfluorinated organolithium reagents or
Ruppert’s reagent (TMS-CF<sub>3</sub>) to isopropylidene tartaric
dichloride, is reported. X-ray crystal structures of the TEFDDOLs
alone or in complexes with H-bond acceptors such as water and DABCO
revealed that this new class of highly fluorinated chiral 1,4-diols
forms distinct intra- and intermolecular H-bond patterns. Intramolecular
OH–OH bonding accounts for the relatively high acidity of the
perfluoroalkyl TEFDDOLs (p<i>K</i><sub>a</sub> in DMSO:
tetrakis-CF<sub>3</sub>, 5.7; tetrakis-C<sub>2</sub>F<sub>5</sub>,
2.4). For the tetrakis(perfluorophenyl) TEFDDOL, a quite unusual “pseudo-anti”
conformation of the diol, with no intramolecular (and no intermolecular)
OH–OH bonds, was found both in the crystal and in solution
(DOSY and NOESY NMR). The latter conformation results from a total
of four intramolecular OH–F<sub>aryl</sub> hydrogen bonds overriding
OH–OH bonding. Due to their H-bonding properties, the TEFDDOLs
are promising new building blocks for supramolecular and potentially
catalytic applications
Large-Scale Synthesis of Singh’s Catalyst in a One-Pot Procedure Starting from Proline
A practical one-pot procedure for the preparation of
Singh’s
catalyst from either l-/d-proline or Boc-proline
is described. The coupling partner, a chiral amino alcohol, can be
prepared and used directly without purification from the corresponding
amino acid ester. Moreover, a procedure for <i>tert</i>-butoxycarbonyl
(Boc) group removal using concentrated HCl in MeOH–DCM was
developed and utilized for the multigram-scale synthesis of Singh’s
catalyst
Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol SynthesisA Caveat on Reaction Times and Product Isolation
Aldol reactions with trifluoroacetophenones as acceptors
yield
chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable
intermediates in organic synthesis. Of the various organocatalysts
examined, Singh’s catalyst [(2<i>S</i>)-<i>N</i>-[(1<i>S</i>)-1-hydroxydiphenylmethyl-3-methylbutyl]-2-pyrrolidinecarboxamide]
was found to efficiently promote this organocatalytic transformation
in a highly enantioselective manner. Detailed reaction monitoring
(<sup>19</sup>F-NMR, HPLC) showed that, up to full conversion, the
catalytic transformation proceeds under kinetic control and affords
up to 95% ee in a time-independent manner. At longer reaction times,
the catalyst effects racemization. For the product aldols, even weak
acids (such as ammonium chloride) or protic solvents, can induce racemization,
too. Thus, acid-free workup, at carefully chosen reaction time, is
crucial for the isolation of the aldols in high (and stable) enantiomeric
purity. As evidenced by <sup>19</sup>F-NMR, X-ray structural analysis,
and independent synthesis of a stable intramolecular variant, Singh’s
catalyst reversibly forms a catalytically inactive (“parasitic”)
intermediate, namely a <i>N</i>,<i>O</i>-hemiacetal
with trifluoroacetophenones. X-ray crystallography also allowed the
determination of the product aldols’ absolute configuration
(<i>S</i>)
Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol SynthesisA Caveat on Reaction Times and Product Isolation
Aldol reactions with trifluoroacetophenones as acceptors
yield
chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable
intermediates in organic synthesis. Of the various organocatalysts
examined, Singh’s catalyst [(2<i>S</i>)-<i>N</i>-[(1<i>S</i>)-1-hydroxydiphenylmethyl-3-methylbutyl]-2-pyrrolidinecarboxamide]
was found to efficiently promote this organocatalytic transformation
in a highly enantioselective manner. Detailed reaction monitoring
(<sup>19</sup>F-NMR, HPLC) showed that, up to full conversion, the
catalytic transformation proceeds under kinetic control and affords
up to 95% ee in a time-independent manner. At longer reaction times,
the catalyst effects racemization. For the product aldols, even weak
acids (such as ammonium chloride) or protic solvents, can induce racemization,
too. Thus, acid-free workup, at carefully chosen reaction time, is
crucial for the isolation of the aldols in high (and stable) enantiomeric
purity. As evidenced by <sup>19</sup>F-NMR, X-ray structural analysis,
and independent synthesis of a stable intramolecular variant, Singh’s
catalyst reversibly forms a catalytically inactive (“parasitic”)
intermediate, namely a <i>N</i>,<i>O</i>-hemiacetal
with trifluoroacetophenones. X-ray crystallography also allowed the
determination of the product aldols’ absolute configuration
(<i>S</i>)
Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol SynthesisA Caveat on Reaction Times and Product Isolation
Aldol reactions with trifluoroacetophenones as acceptors
yield
chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable
intermediates in organic synthesis. Of the various organocatalysts
examined, Singh’s catalyst [(2<i>S</i>)-<i>N</i>-[(1<i>S</i>)-1-hydroxydiphenylmethyl-3-methylbutyl]-2-pyrrolidinecarboxamide]
was found to efficiently promote this organocatalytic transformation
in a highly enantioselective manner. Detailed reaction monitoring
(<sup>19</sup>F-NMR, HPLC) showed that, up to full conversion, the
catalytic transformation proceeds under kinetic control and affords
up to 95% ee in a time-independent manner. At longer reaction times,
the catalyst effects racemization. For the product aldols, even weak
acids (such as ammonium chloride) or protic solvents, can induce racemization,
too. Thus, acid-free workup, at carefully chosen reaction time, is
crucial for the isolation of the aldols in high (and stable) enantiomeric
purity. As evidenced by <sup>19</sup>F-NMR, X-ray structural analysis,
and independent synthesis of a stable intramolecular variant, Singh’s
catalyst reversibly forms a catalytically inactive (“parasitic”)
intermediate, namely a <i>N</i>,<i>O</i>-hemiacetal
with trifluoroacetophenones. X-ray crystallography also allowed the
determination of the product aldols’ absolute configuration
(<i>S</i>)
Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol SynthesisA Caveat on Reaction Times and Product Isolation
Aldol reactions with trifluoroacetophenones as acceptors
yield
chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable
intermediates in organic synthesis. Of the various organocatalysts
examined, Singh’s catalyst [(2<i>S</i>)-<i>N</i>-[(1<i>S</i>)-1-hydroxydiphenylmethyl-3-methylbutyl]-2-pyrrolidinecarboxamide]
was found to efficiently promote this organocatalytic transformation
in a highly enantioselective manner. Detailed reaction monitoring
(<sup>19</sup>F-NMR, HPLC) showed that, up to full conversion, the
catalytic transformation proceeds under kinetic control and affords
up to 95% ee in a time-independent manner. At longer reaction times,
the catalyst effects racemization. For the product aldols, even weak
acids (such as ammonium chloride) or protic solvents, can induce racemization,
too. Thus, acid-free workup, at carefully chosen reaction time, is
crucial for the isolation of the aldols in high (and stable) enantiomeric
purity. As evidenced by <sup>19</sup>F-NMR, X-ray structural analysis,
and independent synthesis of a stable intramolecular variant, Singh’s
catalyst reversibly forms a catalytically inactive (“parasitic”)
intermediate, namely a <i>N</i>,<i>O</i>-hemiacetal
with trifluoroacetophenones. X-ray crystallography also allowed the
determination of the product aldols’ absolute configuration
(<i>S</i>)
1,4-Bis-Dipp/Mes-1,2,4-Triazolylidenes: Carbene Catalysts That Efficiently Overcome Steric Hindrance in the Redox Esterification of α- and β‑Substituted α,β-Enals
As
reported by Scheidt and Bode in 2005, sterically nonencumbered
α,β-enals are readily converted to saturated esters in
the presence of alcohols and N-heterocyclic carbene catalysts, e.g.,
benzimidazolylidenes or triazolylidenes. However, substituents at
the α- or β-position of the α,β-enal substrate
are typically not tolerated, thus severely limiting the substrate
spectrum. On the basis of our earlier mechanistic studies, a set of <i>N</i>-Mes- or <i>N</i>-Dipp-substituted 1,2,4-triazolium
salts were synthesized and evaluated as (pre)catalysts in the redox
esterification of various α- or β-substituted enals. In
particular the 1,4-bis-Mes/Dipp-1,2,4-triazolylidenes overcome the
above limitations and efficiently catalyze the redox esterification
of a whole series of α/β-substituted enals hitherto not
amenable to NHC-catalyzed transformations. The synthetic value of
1,4-bis-Mes/Dipp-1,2,4-triazolylidenes is further demonstrated by
the one-step bicyclization of 10-oxocitral to (racemic) nepetalactone
in diastereomerically pure form
Chemoenzymatic Synthesis of Vitamin B5-Intermediate (<i>R</i>)‑Pantolactone via Combined Asymmetric Organo- and Biocatalysis
The combination of an asymmetric
organocatalytic aldol reaction
with a subsequent biotransformation toward a “one-pot-like”
process for the synthesis of (<i>R</i>)-pantolactone, which
to date is industrially produced by a resolution process, is demonstrated.
This process consists of an initial aldol reaction catalyzed by readily
available l-histidine followed by biotransformation of the
aldol adduct by an alcohol dehydrogenase without the need for intermediate
isolation. Employing the industrially attractive starting material
isobutanal, a chemoenzymatic three-step process without intermediate
purification is established allowing the synthesis of (<i>R</i>)-pantolactone in an overall yield of 55% (three steps) and high
enantiomeric excess of 95%