Genome coverage for viruses present in URTI samples.

a<p>RSV, respiratory syncytial virus; RV-A, rhinovirus species A; RV-B; rhinovirus species B; RV-C; rhinovirus species C; HBoV, human bocavirus, HCoV, human coronavirus OC43; TTV, torque teno virus; TTMV, torque teno mini virus; TTMDV, torque teno midi virus; BKV, bovine kobuvirus; BVDV, bovine viral diarrhea virus; BatPV, bat picornavirus; HPV, human papillomavirus; PVY, potato virus Y, ToMV, tomato mosaic virus; CMV, cucumber mosaic virus; HHV, human herpes virus; HVE-A, human enterovirus A; SAFV, Saffold virus; WSSV, white spot syndrome virus; HASTV, human astrovirus.</p><p>Genome coverage for viruses present in URTI samples.</p

DNA reads obtained after NGS sequencing of LRTI samples.

a<p>Valid DNA reads after discarding those that did not pass the quality filter, and removing repeated reads (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113570#s2" target="_blank">Methods</a>).</p><p>DNA reads obtained after NGS sequencing of LRTI samples.</p

Pathogens identified by NGS in children with lower respiratory tract infections.

a<p>Number of valids DNA reads in the sample por the corresponding pathogen.</p><p>Pathogens identified by NGS in children with lower respiratory tract infections.</p

DNA reads obtained after NGS sequencing of URTI samples.

a<p>The samples that were pooled for sequencing are indicated.</p>b<p>Valid DNA reads after discarding those that did not pass the quality filter, and removing repeated reads (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113570#s2" target="_blank">Methods</a>).</p><p>DNA reads obtained after NGS sequencing of URTI samples.</p

Frequency of viral pathogens in children with URTI and LRTI.

a<p>The number of viruses include those present in single and mixed infections. The percentage refers to the total number of viruses detected.</p><p>Frequency of viral pathogens in children with URTI and LRTI.</p

Taxonomic classification of the generated DNA sequencing reads.

<p>Valid DNA reads obtained by NGS of LRTI and URTI clinical samples were split into human, bacterial, fungal, and viral origin. Those reads not present in the four previous categories were classified as "undefined". Average values for all LRTI and URTI samples are shown.</p

Pathogens identified by NGS in children with upper respiratory tract infections.

a<p>When more than one sample were pooled for sequencing, the code for the various samples is mentioned.</p>b<p>Number of valids DNA reads in the sample por the corresponding pathogen.</p><p>Pathogens identified by NGS in children with upper respiratory tract infections.</p