1 research outputs found
Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides
A novel approach
to hemiaminal synthesis via palladium-catalyzed
C–N coupling with chiral bisphosphine mono-oxides is described.
This efficient new method exhibits a broad scope, provides a highly
efficient synthesis of HCV drug candidate elbasvir, and has been applied
to the synthesis of chiral <i>N,N</i>-acetals