1 research outputs found
Acute Motor Axonal Neuropathy in Association with Hepatitis E
Guillain–Barré syndrome (GBS) is an acute peripheral neuropathy that develops
as a result of post-infectious immune-mediated nerve injury. It can be
classified into classic and variant GBS. Acute motor axonal neuropathy (AMAN)
is a subtype of GBS with the key clinical features of pure motor weakness,
areflexia, absence of sensory symptoms, and lack of neurophysiologic evidence
of demyelination. We reported a case of acute motor axonal neuropathy in
association with hepatitis E infection. A young woman was referred to us after
a period of nausea, fever, and diarrhea. She had unexplained muscle weakness
at admission and has been diagnosed with acute hepatitis E infection. A
rigorous clinical neurological assessment revealed bilateral symmetrical
weakness, which affects the lower limbs more than the upper limbs, with no
evidence of sensory involvement. Neurophysiological measurements indicated
acute axonal injury without clues to demyelination. A diagnosis of acute motor
axonal neuropathy subtype has been made, to which she only received supportive
therapy. The symptoms resolved spontaneously and full recovery of motor
function was attained after 35 days of weakness onset with complete
normalization of neurophysiologic parameters