Parasites may help stabilize cooperative relationships

Background: The persistence of cooperative relationships is an evolutionary paradox; selection should favor those individuals that exploit their partners (cheating), resulting in the breakdown of cooperation over evolutionary time. Our current understanding of the evolutionary stability of mutualisms (cooperation between species) is strongly shaped by the view that they are often maintained by partners having mechanisms to avoid or retaliate against exploitation by cheaters. In contrast, we empirically and theoretically examine how additional symbionts, specifically specialized parasites, potentially influence the stability of bipartite mutualistic associations. In our empirical work we focus on the obligate mutualism between fungus-growing ants and the fungi they cultivate for food. This mutualism is exploited by specialized microfungal parasites (genus Escovopsis) that infect the ant's fungal gardens. Using sub-colonies of fungus-growing ants, we investigate the interactions between the fungus garden parasite and cooperative and experimentally-enforced uncooperative ("cheating") pairs of ants and fungi. To further examine if parasites have the potential to help stabilize some mutualisms we conduct Iterative Prisoner's Dilemma (IPD) simulations, a common framework for predicting the outcomes of cooperative/non-cooperative interactions, which incorporate parasitism as an additional factor. Results: In our empirical work employing sub-colonies of fungus-growing ants, we found that Escovopsis-infected sub-colonies composed of cheating populations of ants or fungi lost significantly more garden biomass than sub-colonies subjected to infection or cheating (ants or fungi) alone. Since the loss of fungus garden compromises the fitness of both mutualists, our findings suggest that the potential benefit received by the ants or fungi for cheating is outweighed by the increased concomitant cost of parasitism engendered by non-cooperation (cheating). IPD simulations support our empirical results by confirming that a purely cooperative strategy, which is unsuccessful in the classic IPD model, becomes stable when parasites are included. Conclusion: Here we suggest, and provide evidence for, parasitism being an external force that has the potential to help stabilize cooperation by aligning the selfish interests of cooperative partners in opposition to a common enemy. Specifically, our empirical results and IPD simulations suggest that when two mutualists share a common enemy selection can favor cooperation over cheating, which may help explain the evolutionary stability of some mutualisms

Mechanism of the High-Tc Superconducting Dynamo: Models and Experiment

High-Tc superconducting (HTS) dynamos are experimentally proven devices that can produce large, >kA, DC currents in superconducting circuits, without the thermal leak associated with copper current leads. However, these DC currents are theoretically controversial, as it is not immediately apparent why a device that is topologically identical to an AC alternator should give a DC output at all. Here, we present a finite-element model, and its comparison with experiment, which fully explains this effect. It is shown that the DC output arises naturally from Maxwell’s laws, when time-varying overcritical eddy currents are induced to circulate in an HTS sheet. We first show that our finite-element model replicates all of the the experimental electrical behavior reported so far for these devices, including the DC output characteristics, and transient electrical waveforms. Direct experimental evidence for the presence of circulating eddy currents is also obtained through measurements of the transient magnetic field profile across the HTS tape, using a linear Hall array. These results are also found to closely agree with predictions from the finite-element model. Following this experimental validation, calculated sheet current densities and the associated local electric fields are examined for a range of frequencies and net transport currents. We find that the electrical output from an HTS dynamo is governed by the competition between transport and eddy currents induced as the magnet transits across the HTS tape. These eddy currents are significantly higher (∼1.5X) than the local critical current density J_c, and hence experience a highly non-linear local resistivity. This non-linearity breaks the symmetry observed in a normal ohmic material, which usually requires the net transport current to vary linearly with the average electric field. The interplay between local current densities and non-linear resistivities (which both vary in time and space) is shown to systematically give rise to the key observed parameters for experimental HTS dynamo devices: the open-circuit voltage V_oc, the internal resistance R_int, and the short-circuit current I_sc. Finally, we identify that the spatial boundaries formed by each edge of the HTS stator tape play a vital role in determining the total DC output. This offers the potential to develop new designs for HTS dynamo devices, for which the internal resistance is greatly reduced and the short circuit current is substantially increased.New Zealand (NZ) MBIE Endeavour Grant No. RTVU1707 NZ Royal Society Marsden Grant No. MFP-VUW1806

The dissemination and implementation of national asthma guidelines in south africa: the use of outcome mapping

Asthma is an important chronic inflammatory disorder with significant morbidity and mortality in South Africa. The development of national asthma guidelines by the South African Thoracic Society and National Asthma Education Programme has been one approach to try and improve the quality of care. The impact of previous guidelines has been limited and therefore it is hoped that the newly revised 2007 guidelines will have a more effective approach to dissemination, implementation and evaluation. Outcome mapping (OM) is one approach to integrated planning, monitoring and evaluation of projects that intend to contribute to change in complex systems. It has a structured, systematic and logical approach that focuses on changes in behaviour, actions or relationships in the people or organizations that the project is working with. OM has three stages - intentional design, outcome/performance monitoring and evaluation - which are described in this article and illustrated with reference to the Asthma Guideline Implementation Project (AGIP). In the intentional design stage the AGIP created a vision and mission statement to guide the project and then identified seven boundary partners. For each boundary partner the AGIP defined the project's outcome challenge and a series of progress markers to monitor achievement of the outcome. Following this the AGIP conceptualized the strategies and organizational practices that will be engaged with to realize the outcomes. In the monitoring stage the AGIP will regularly document and reflect on the progress markers, strategies and organizational practices using pre-determined structured journals. In the evaluation stage there is the opportunity to plan the evaluation of key aspects of the project in more depth. In the AGIP project the team engaged with the development of a doctoral research project to evaluate the process of implementation in private and public primary care settings in the Cape Town metropole. This article describes the methodology of Outcome Mapping and illustrates this in relation to the Asthma Guidelines Implementation Project. The methodology has the potential to be applied in many other development projects and is also congruent with action research. It is hoped that the readers will find this approach useful in their own settings

Numerical modelling of dynamic resistance in high-temperature superconducting coated-conductor wires

The use of superconducting wire within AC power systems is complicated by the dissipative interactions that occur when a superconductor is exposed to an alternating current and/or magnetic field, giving rise to a superconducting AC loss caused by the motion of vortices within the superconducting material. When a superconductor is exposed to an alternating field whilst carrying a constant DC transport current, a DC electrical resistance can be observed, commonly referred to as “dynamic resistance.” Dynamic resistance is relevant to many potential high-temperature superconducting (HTS) applications and has been identified as critical to understanding the operating mechanism of HTS flux pump devices. In this paper, a 2D numerical model based on the finite-element method and implementing the H-formulation is used to calculate the dynamic resistance and total AC loss in a coated-conductor HTS wire carrying an arbitrary transport current and exposed to background AC magnetic fields up to 100 mT. The measured angular dependence of the superconducting properties of the wire are used as input data, and the model is validated using experimental data for magnetic fields perpendicular to the plane of the wire, as well as at angles of 30° and 60° to this axis. The model is used to obtain insights into the characteristics of such dynamic resistance, including its relationship with the applied current and field, the wire’s superconducting properties, the threshold field above which dynamic resistance is generated and the flux-flow resistance that arises when the total driven transport current exceeds the field-dependent critical current, Ic(B), of the wire. It is also shown that the dynamic resistance can be mostly determined by the perpendicular field component with subtle differences determined by the angular dependence of the superconducting properties of the wire. The dynamic resistance in parallel fields is essentially negligible until Jc is exceeded and flux-flow resistance occurs

Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m

Upon ascent to high altitude, cerebral blood flow (CBF) rises substantially before returning to sea-level values. The underlying mechanisms for these changes are unclear. We examined three hypotheses: (1) the balance of arterial blood gases upon arrival at and across 2 weeks of living at 5050 m will closely relate to changes in CBF; (2) CBF reactivity to steady-state changes in CO2 will be reduced following this 2 week acclimatisation period, and (3) reductions in CBF reactivity to CO2 will be reflected in an augmented ventilatory sensitivity to CO2. We measured arterial blood gases, middle cerebral artery blood flow velocity (MCAv, index of CBF) and ventilation () at rest and during steady-state hyperoxic hypercapnia (7% CO2) and voluntary hyperventilation (hypocapnia) at sea level and then again following 2–4, 7–9 and 12–15 days of living at 5050 m. Upon arrival at high altitude, resting MCAv was elevated (up 31 ± 31%; P < 0.01; vs. sea level), but returned to sea-level values within 7–9 days. Elevations in MCAv were strongly correlated (R2= 0.40) with the change in ratio (i.e. the collective tendency of arterial blood gases to cause CBF vasodilatation or constriction). Upon initial arrival and after 2 weeks at high altitude, cerebrovascular reactivity to hypercapnia was reduced (P < 0.05), whereas hypocapnic reactivity was enhanced (P < 0.05 vs. sea level). Ventilatory response to hypercapnia was elevated at days 2–4 (P < 0.05 vs. sea level, 4.01 ± 2.98 vs. 2.09 ± 1.32 l min−1 mmHg−1). These findings indicate that: (1) the balance of arterial blood gases accounts for a large part of the observed variability (∼40%) leading to changes in CBF at high altitude; (2) cerebrovascular reactivity to hypercapnia and hypocapnia is differentially affected by high-altitude exposure and remains distorted during partial acclimatisation, and (3) alterations in cerebrovascular reactivity to CO2 may also affect ventilatory sensitivity

Off the Couch and Onto the Streets: Toward an Ethnographic Psychoanalysis

Psychoanalysis has much to gain by incorporating ethnographic methods into its repertoire. Recent works in ethnographic psychoanalysis demonstrate how psychoanalysis stands to function better as both community intervention and participatory action research. This article describes the historical convergence between psychoanalysis and cultural anthropology and situates ethnographic psychoanalysis within interdisciplinary theory and practice

Fast and efficient critical state modelling of field-cooled bulk high-temperature superconductors using a backward computation method

Abstract: A backward computation method has been developed to accelerate modelling of the critical state magnetization current in a staggered-array bulk high-temperature superconducting (HTS) undulator. The key concept is as follows: (i) a large magnetization current is first generated on the surface of the HTS bulks after rapid field-cooling (FC) magnetization; (ii) the magnetization current then relaxes inwards step-by-step obeying the critical state model; (iii) after tens of backward iterations the magnetization current reaches a steady state. The simulation results show excellent agreement with the H -formulation method for both the electromagnetic and electromagnetic-mechanical coupled analyses, but with significantly faster computation speed. The simulation results using the backward computation method are further validated by the recent experimental results of a five-period Gd–Ba–Cu–O (GdBCO) bulk undulator. Solving the finite element analysis (FEA) model with 1.8 million degrees of freedom (DOFs), the backward computation method takes less than 1.4 h, an order of magnitude or higher faster than other state-of-the-art numerical methods. Finally, the models are used to investigate the influence of the mechanical stress on the distribution of the critical state magnetization current and the undulator field along the central axis

A Trapped Field of 17.6 T in Melt-Processed, Bulk Gd-Ba-Cu-O Reinforced with Shrink-Fit Steel

The ability of large grain, REBa$_{2}$Cu$_{3}$O$_{7-\delta}$ [(RE)BCO; RE = rare earth] bulk superconductors to trap magnetic field is determined by their critical current. With high trapped fields, however, bulk samples are subject to a relatively large Lorentz force, and their performance is limited primarily by their tensile strength. Consequently, sample reinforcement is the key to performance improvement in these technologically important materials. In this work, we report a trapped field of 17.6 T, the largest reported to date, in a stack of two, silver-doped GdBCO superconducting bulk samples, each of diameter 25 mm, fabricated by top-seeded melt growth (TSMG) and reinforced with shrink-fit stainless steel. This sample preparation technique has the advantage of being relatively straightforward and inexpensive to implement and offers the prospect of easy access to portable, high magnetic fields without any requirement for a sustaining current source.Comment: Updated submission to reflect licence change to CC-BY. This is the "author accepted manuscript" and is identical in content to the published versio

Mathematical analysis of PWM processes

Pulse width modulation (PWM) inverters convert a direct current (DC) power supply to an alternating current (AC) supply by means of high frequency switching between two DC sources. Undesirable high-frequency components are generated in the frequency spectra of the voltages and currents of PWM inverters. The high-frequency components are ultimately removed from the input and output waveforms by filters. PWM inverters are used in a wide variety of electrical devices, ranging from microwave ovens to the electrical parts of aircraft. In many of these devices, minimising the size and weight of the electrical parts is important, and, consequently, it is desirable to design efficient filters for PWM inverters. Identification of the unwanted high-frequency components allows for optimal filter design. In this thesis we use alternative methods to calculate the voltages and currents of PWM inverters. Mathematical models are developed for several PWM inverter designs, and Fourier analysis of the mathematical expressions for the currents and voltages allow us to determine frequency spectra. The methods used in this thesis are shown to be more suitable to the calculation of spectra for complex inverter designs, compared to conventional techniques. In particular, input current spectra are calculated for PWM inverters that incorporate dead time and space vector modulation (SVM) inverters for the first time here