Bis-Thiourea Bearing Aryl and Amino Acids Side Chains and Their Antibacterial Activities

<div><p></p><p>A series of symmetrical 1,3-bis thiourea <b>1a–e</b> and 1,4-bis thiourea derivatives <b>2a–e</b> have been successfully synthesized from the reactions of amines with 3-acetylbenzoyl isothiocyanate and 4-acetylbenzoyl isothiocyanate, respectively. All the synthesized compounds were characterized by FT-IR spectroscopy and ¹H and ¹³C NMR spectroscopy. The compounds were screened for their antibacterial activity by turbidimetric method using gram-negative bacteria (E. coli ATCC 8739) using turbidimetric method. The newly synthesized bis-thiourea derivatives bearing aryl side chains showed good antibacterial activity against <i>E. coli</i>. The effect of the molecular structure of the synthesized compounds on the antibacterial activity is discussed.</p></div