Dyeing performance on polyester fibers and DFT investigation of newly synthesized 2-arylazo-dioxoisoindolinecyanoacetamide derivatives

A series of aryl-diazinyl-cyanoacetamide (2a–l) were prepared by coupling the appropriate diazotized arylamines with dioxoisoindoline cyanaoacetamide (1). Also, the cyclization of azo derivatives (2f, 2h, and 2j) with chloroacetonitrile to yield the pyrazole derivatives (5f, 5h, and 5j) was studied. Moreover, compound 2d reacts with malononitrile to afford compound (6e). In a similar manner compound, 2d reacts with hydroxylamine to afford the sole product tetrazine derivative 8d. All the newly synthesized compounds were fully characterized by both analytical and spectral analyses. The geometries of the azo and hydrazo tautomeric forms were optimized at the B3LYP/6-311G level of theory. The dyeing performance of the synthesized dyes on polyester fibers has been assessed. Most of the dyes showed a good affinity to polyester fibers. No details regarding the synthesis and dyeing performance of such dyes are reported before in the literature.</p

Design, Synthesis, Biological Evaluation of New Porphyrin and Metalloporphyrin Derivatives

In our research, we produced some novel porphyrin derivatives 4a–g in high yields. We also synthesized and characterized some of their metalloporphyrin complexes 5–11. The structures of these novel porphyrins were assured by spectroscopic techniques. The geometric structure and magnetic properties of metallo-porphyrins 5–11 have also been studied. Antiviral and antitumor activities were estimated and the structures activity relationships were accomplished. The Porphyrin derivatives 4g, 4f, 9, 10 and 11 displayed strong antiviral activity for HSV-1 compared to Aphidicoline as reference. While derivatives 4g and 6 exhibited very strong activity against HIV-1. Porphyrin derivatives 4g, 6, 9, and 10, in general, displayed strong activity against all the tested human cell lines.</p

Synthesis of some new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives as antibacterial agents

<p>Benzoylacetone has been reacted with phenyl isothiocyanate to afford two different thiocarbamoyl derivatives (α-phenylthiocarbamoyl benzoylacetone and benzoyl thioacetanilide) depending upon the base used to perform the reaction. Several new 2-substituted-4-sulfamoylphenylazo-thiophene and/or thiazole derivatives were synthesized by heterocyclization of the thiocarbamoyl derivatives with various halogenated reagents. The synthesized compounds were screened for their antibacterial activities; they showed accepted activities with respect to the control drugs.</p

Additional file 1 of Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents

Additional file 1: Figures S1–S82.Additional figures S1–S2