4 research outputs found
Blood glucose-lowering effect of Telfairia Occidentalis : A preliminary study on the underlying mechanism and responses
The effects of aqueous extract of Telfairia Occidentalis leaf (TO) on
plasma glucose, lactate dehydrogenase activity (LDH), insulin and
cortisol levels in rats were investigated. Thirty male Wistar rats
(200 12250g) were randomly divided into 5 groups (n=6/group). Rats
in the control group received 0.2 ml of normal saline while rats in
other groups were orally treated with 100 or 200 mg/Kg of the extract
for either 1 or 2 weeks. The results showed that there were significant
increases in insulin and cortisol levels, decrease in glucose, and an
insignificant increase in LDH activity in rats treated with 100 and 200
mg/Kg of the extract for 1 week. However, after 2 weeks of treatment
with the same doses, there was no significant change in plasma insulin
in the treated rats when compared with the control. In contrast, there
was a significant decrease in plasma insulin levels when compared with
what was obtained after one week of treatment. The reduction in plasma
insulin was accompanied by increases in plasma glucose towards normal
and significant increases in plasma cortisol and LDH activity. The
results suggest that the blood glucose-lowering effect of Telfairia
Occidentalis might be mediated at least in part by insulin. This effect
elicited counterregulatory responses that included an increase in
plasma cortisol and lactate dehydrogenase activity to probably
stimulate cortisol-induced gluconeogenesis and favor lactate oxidation
Blood glucose-lowering effect of Telfairia Occidentalis : A preliminary study on the underlying mechanism and responses
The effects of aqueous extract of Telfairia Occidentalis leaf (TO) on
plasma glucose, lactate dehydrogenase activity (LDH), insulin and
cortisol levels in rats were investigated. Thirty male Wistar rats
(200−250g) were randomly divided into 5 groups (n=6/group). Rats
in the control group received 0.2 ml of normal saline while rats in
other groups were orally treated with 100 or 200 mg/Kg of the extract
for either 1 or 2 weeks. The results showed that there were significant
increases in insulin and cortisol levels, decrease in glucose, and an
insignificant increase in LDH activity in rats treated with 100 and 200
mg/Kg of the extract for 1 week. However, after 2 weeks of treatment
with the same doses, there was no significant change in plasma insulin
in the treated rats when compared with the control. In contrast, there
was a significant decrease in plasma insulin levels when compared with
what was obtained after one week of treatment. The reduction in plasma
insulin was accompanied by increases in plasma glucose towards normal
and significant increases in plasma cortisol and LDH activity. The
results suggest that the blood glucose-lowering effect of Telfairia
Occidentalis might be mediated at least in part by insulin. This effect
elicited counterregulatory responses that included an increase in
plasma cortisol and lactate dehydrogenase activity to probably
stimulate cortisol-induced gluconeogenesis and favor lactate oxidation
Attitude and predictors of exclusive breastfeeding practice among mothers attending under-five welfare clinics in a rural community in Southwestern Nigeria.
BackgroundMuch previous research on exclusive breastfeeding has focused on urban and semi-urban communities, while there is still a paucity of data from rural areas. We assessed the attitude and practice of exclusive breastfeeding and its predictors among mothers attending the under-five welfare clinics in a rural community.MethodsA cross-sectional study was conducted among consecutively recruited 217 mothers attending the three health facilities under-five welfare clinics in Ido-Ekiti, Southwest, Nigeria. Information was collected with a semi-structured interviewer-administered questionnaire adapted from previously published research works. Descriptive and inferential statistics were carried out using IBM SPSS Statistics for Windows, Version 26.0.ResultsMore than half of the mothers, 117(53.9%) were ≥30 years old, and 191(88.0%) were married. Almost all, 216 (99.5%) attended an ante-natal clinic; however, 174(80.2%) delivered in the health facility. The respondent's mean ± SD exclusive breastfeeding attitudinal score was 29.94 ± 2.14 (maximum obtainable score was 36), and the proportion of mothers that practiced exclusive breastfeeding was 40.6%. Married mothers were more likely to practice exclusive breastfeeding than their unmarried counterparts (AOR:6.324, 95%CI:1.809-22.114). The common reasons for not practicing exclusive breastfeeding were work schedule 57(26.3%), cultural beliefs and the need to introduce herbal medicine 32(14.7%), and insufficient breast milk 30(13.8%).ConclusionThis study revealed a good disposition with a suboptimal practice towards exclusive breastfeeding. Also, being married was a positive predictor of exclusive breastfeeding. Therefore, we recommend policies that will improve exclusive breastfeeding among mothers in rural areas, especially those targeting the unmarried, to achieve the World Health Organization's target