Comparing the Analgesic Effect of Aminophylline and Hyoscine with Morphine on Renal Colic: a Randomized Clinical Trial

Introduction: Although narcotics are effective for pain relief in these patients, they have little impact on the underlying cause. Therefore, surveys have been conducted to find more effective agents. Objective: This study conducted to compare the analgesic effect of aminophylline and hyoscine combination with morphine on renal colic patients. Methods: This double-blind clinical trial was conducted on patients with renal colic caused by urinary tract stones. Subjects were selected via convenience sampling method. Patients were randomly divided into two groups based on whether they received aminophylline + hyoscine or morphine. Before drug administration, one researcher was asked to measure the pain of the patients using Graduated Numbered Visual Analogue Scale (GN-VAS). Afterward, 20 mg of hyoscine along with 3 mg/kg of aminophylline in 100 cc normal saline was injected during 10 minutes into patients in the one group, whereas 0.1 mg/kg of morphine was intravenously with 100 cc normal saline to align two groups, administered to the subjects in another group. Half an hour after the administration of drugs, pain was measured for the second time. Vital signs and side effects were all recorded. Results: In this study, 95 patients (47 patients in the aminophylline+hyoscine group and 48 patients in the morphine group) remained in the trial until the end. The difference in sex distribution(p=0.227) and age(p=0.680) of the two groups was not statistically significant. Median of pain intensity was not significantly different between the two study groups (p<0.05), neither before nor after administration of the drugs. The mean time required for pain relief in morphine group was significantly lower than aminophylline+hyoscine group (5.9±1.6 vs. 11.1±1.6 minutes; p<0.001). Conclusion: Overall, our findings indicated that aminophylline + hyoscine combination was effective in reducing renal colic pain and there is no significant difference between this combination and morphine in terms of pain relief

Comparing the Analgesic Effect of Aminophylline and Hyoscine with Morphine on Renal Colic: a Randomized Clinical Trial

Introduction: Although narcotics are effective for pain relief in these patients, they have little impact on the underlying cause. Therefore, surveys have been conducted to find more effective agents. Objective: This study conducted to compare the analgesic effect of aminophylline and hyoscine combination with morphine on renal colic patients. Methods: This double-blind clinical trial was conducted on patients with renal colic caused by urinary tract stones. Subjects were selected via convenience sampling method. Patients were randomly divided into two groups based on whether they received aminophylline + hyoscine or morphine. Before drug administration, one researcher was asked to measure the pain of the patients using Graduated Numbered Visual Analogue Scale (GN-VAS). Afterward, 20 mg of hyoscine along with 3 mg/kg of aminophylline in 100 cc normal saline was injected during 10 minutes into patients in the one group, whereas 0.1 mg/kg of morphine was intravenously with 100 cc normal saline to align two groups, administered to the subjects in another group. Half an hour after the administration of drugs, pain was measured for the second time. Vital signs and side effects were all recorded. Results: In this study, 95 patients (47 patients in the aminophylline+hyoscine group and 48 patients in the morphine group) remained in the trial until the end. The difference in sex distribution(p=0.227) and age(p=0.680) of the two groups was not statistically significant. Median of pain intensity was not significantly different between the two study groups (p<0.05), neither before nor after administration of the drugs. The mean time required for pain relief in morphine group was significantly lower than aminophylline+hyoscine group (5.9±1.6 vs. 11.1±1.6 minutes; p<0.001). Conclusion: Overall, our findings indicated that aminophylline + hyoscine combination was effective in reducing renal colic pain and there is no significant difference between this combination and morphine in terms of pain relief

Rapid Acute Physiology Score versus Rapid Emergency Medicine Score in Trauma Outcome Prediction; a Comparative Study

Introduction: Rapid acute physiology score (RAPS) and rapid emergency medicine score (REMS) are two physiologic models for measuring injury severity in emergency settings. The present study was designed to compare the two models in outcome prediction of trauma patients presenting to emergency department (ED).Methods: In this prospective cross-sectional study, the two models of RAPS and REMS were compared regarding prediction of mortality and poor outcome (severe disability based on Glasgow outcome scale) of trauma patients presenting to the EDs of 5 educational hospitals in Iran (Tehran, Tabriz, Urmia, Jahrom and Ilam) from May to October 2016. The discriminatory power and calibration of the models were calculated and compared using STATA 11.Results: 2148 patients with the mean age of 39.50±17.27 years were studied (75.56% males). The area under the curve of REMS and RAPS in predicting in-hospital mortality were calculated to be 0.93 (95% CI: 0.92-0.95) and 0.899 (95% CI: 0.86-0.93), respectively (p=0.02). These measures were 0.92 (95% CI: 0.90-0.94) and 0.86 (95% CI: 0.83-0.90), respectively, regarding poor outcome (p=0.001). The optimum cut-off point in predicting outcome was found to be 3 for REMS model and 2 for RAPS model. The sensitivity and specificity of REMS and RAPS in the mentioned cut offs were 95.93 vs. 85.37 and 77.63 vs. 83.51, respectively, in predicting mortality. Calibration and overall performance of the two models were acceptable.Conclusion: The present study showed that adding age and level of arterial oxygen saturation to the variables included in RAPS model can increase its predictive value. Therefore, it seems that REMS could be used for predicting mortality and poor outcome of trauma patients in emergency setting

The Relationship between the Results of Coagulation Profile and Severity of Pulmonary Involvement in COVID-19 Patients

Introduction: COVID-19 is currently a global pandemic, and coagulation-related mortality has been widely reported in patients suffering from it. Objective: this article aimed to investigate the coagulation profile of COVID-19 patients. Methods: This was a cross-sectional study conducted using a retrospective research design. We recruited patients with COVID-19 admitted to a hospital from June 15th to July 7th, 2020. Upon patients' entering a blood sample was drawn from each patient for assessing patient’s coagulation profile (PT, PTT, INR, Platelet count); and a chest high-resolution computed tomography (HRCT) scan was performed for each patient. The study patients were divided in to sever group (CO-RADS score 5) and non-sever group (CO-RADS score <5). Results: Thirty-six patients (20 males and 16 females) with a mean age of 54.7±17.5 years were studied. Of them, 11 cases (30.56%) had severe pulmonary involvement. Also, the coagulation profiles were longer in the severe group than non-sever group. As well, the means of platelet count that were 232.440 per microliter in the non-severe group and 289.180 per microliter in the severe and non-sever groups, respectively; but still not statistically significant (p>0.05). The Area under the ROC Curve (AUC) for PT and INR was 0.615 and 0.611, respectively. The AUC for platelet count was 0.680 (95% CI: 0.501 to 0.859) and had an acceptable discriminating power. Conclusions: In this study, we did not find any statistically significant relationship between the results of coagulation tests and the severity of pulmonary involvement according to HRCT scan findings in COVID-19 patients. But further analyses suggest that, except PTT, the other coagulation tests (PT, INR, and platelet count) may discriminate severe COVID-19 patients

Gender Differences in COVID-19 Deceased Cases in Jahrom City, South of Iran

Objective: To evaluate the clinical and epidemiological features of deceased patients and comparing the discrepancies between male and female patients based on high prevalence of coronavirus disease 2019 (COVID-19), its irreversible effects and the rising mortality rate in Jahrom city. Methods: This is a descriptive-analytical retrospective study that was conducted from the beginning of March 2020 to the end of November 2020. The study population were included all patients with COVID-19 who admitted to Peymaniyeh Hospital in Jahrom and died of COVID-19. Clinical and demographic data were collected from medical records and analyzed by SPSS software. Results: In this study, 61 patients (57.54%) were men and 45 patients (42.36%) were women. The mean age was 68.7±18.33 in men and 68.82±14.24 in women. The mean hospitalization length was 9.69±7.75 days in men and 9.69±7.75 days in women patients. There was no statistically significant difference between men and women patients (p>0.05). The results showed that 17 (27.87%) men and 28 (45.9%) of women patients had hypertension and the prevalence of this disease was significantly higher in women than men (p=0.01). In this study, 7 (11.48%) men and 13 (21.31%) women had hyperlipidemia. The frequency of hyperlipidemia in women caseswas significantly higher than in men patients (p=0.024). Men cases’ diastolic blood pressure (mean=77.53) was significantly higher than women’s diastolic blood pressure at the same time with a mean of 71.42 (p <0.05). Conclusion: The findings of the study represented the mortality rate in men which is higher than women patients. The prevalence of underlying diseases such as hypertension and hyperlipidemia were higher in women than men. Despite higher mortality among women, symptoms such as fever and dyspnea were less common in women than men

Assessment of the interns’ ability based on Dundee model in Shiraz University of Medical Sciences

Introduction: The importance of medical profession and the role of the physician in society is no secret to anyone. Skills and competencies in clinical practice are necessary for the medical profession. In fact, in patient care, doctors require practical skills in addition to scientific knowledge. This study examines the potentials of medical school students in three areas of doing the right thing, doing the right thing in an intermediate range, and doing the right thing by the right person. Methods: This study was done in a descriptive-analytical and sectional model. The population of this study was all interns of Shiraz University of Medical Sciences who were passing internship at Internal Medicine, Surgery, Pediatrics, Obstetrics and Emergency wards. About 100 persons were selected were selected by simple randomization. In order to collect data, a questionnaire with 12 questions was designed in two parts. The questionnaire was approved by 7 Faculty members of Clinical Medicine and Medical Education, and its reliability was approved by test-retest method on 20 medical students in the form of a pilot study and through Cronbach’s alpha (82%). Collected data were analyzed by SPSS software version 14 using descriptive statistical methods. Results: Results showed that within the inner circle, interns evaluated their skills in surgery, internal medicine, and gynecology wards, intermediate and at other wards as weak. Also within the center circle, interns evaluated adequate educational evidence-based training in the field of medicine, and sufficiency of educational training in the field of clinical decision making and clinical care as suitable. Conclusion: According to the results, it seems that medical interns’ skills in performing most medical skills are moderate. So teaching students by new educational methods and workshop techniques, using experienced teachers will be effective. The use of clinical skills training centers and objective assessment methods for the students’ skills, especially before entering the clinical departments, is very important

پریشانی اخلاقی و مولفه های مرتبط با آن در پرسنل بخش اورژانس؛ یک مطالعه مروری

Introduction: Moral distress is one of the hidden moral challenges in providing nursing care services that occurs in conditions of impossibility to perform the right job despite knowing its correctness. This challenge is greater among nurses in wards with more acute conditions, such as the emergency department. This study was conducted with the aim of systematically reviewing moral distress and its related components in studies conducted on emergency department employees. Methods: This research is based on a systematic review that evaluates the quality of articles using the STROBE standard checklist. Preliminary studies were conducted through articles in Persian language databases; SID, Iranmedex, Magiran and English language databases; Science Direct, PubMed, ProQuest, Cochrane Library, Embase, Scopus and Google Scholar; was examined. In order to access the full text of articles containing Persian keywords; Moral distress, moral stress, moral stress, moral distress, moral anxiety, moral turmoil, and emergency-related phrases were used as a combination of words; Also includes boolean search methods and OR operators and Mesh keywords; Moral Distress, Ethical Distress, Ethical unease, Ethical disquiet, Emergency were used. Results: In the initial stage, 466 studies were studied. The researchers then reviewed the articles that had been searched, and finally, after removing duplicate, irrelevant items, qualitative studies, narrative review, and a letter to the editor; 18 researches were used to write this research. Among the studies studied, 11 Iranian articles were conducted, which shows 61.11% of the total studies; other studies have been conducted in Taiwan, China, the United States, Indonesia and Switzerland. The average moral distress of emergency department nurses was moderate and there was a significant relationship with components such as background and workload of the findings of these studies. Conclusion: The set of studies performed on emergency department nurses is a reliable number to show the level of moral distress, but this amount of study is not reliable to obtain a model of components and variables related to moral distress. For this purpose, in addition to further research on this group of nurses, by removing the characteristics of emergency department nurses, a systematic review of all studies conducted in the field of moral distress on the nursing community can be done to achieve more accurate results.مقدمه: پریشانی اخلاقی یکی چالش های اخلاقی پنهان در حین ارائه خدمات مراقبتی پرستاران است که در شرایط عدم امکان اجرای کار درست علیرغم آگاهی از درستی آن پیش می آید. این چالش در بین پرستاران بخش هایی که شرایط حاد تری دارند نظیر بخش اورژانس بیشتر است. این تحقیق، با هدف مرور نظام مند پیرامون پریشانی اخلاقی و مولفه های مرتبط با آن در مطالعات انجام شده بر روی پرسنل بخش اورژانس، صورت گرفت. روش کار: این پژوهش مبتنی بر یک مرور نظام‌مند می باشد که ارزیابی کیفیت مقاله ها با استفاده از چک لیست استاندارد STROBE، صورت گرفت. مطالعات اولیۀ انجام شده، از طریق مقاله هایی که در پایگاه‌های اطلاعاتی فارسی زبان؛SID ،Iranmedex،Magiran و پایگاه های انگلیسی زبان؛ Science Direct، PubMed، ProQuest،Cochrane Library،Embase،Scopus و موتور جستجوگر Google Scholar؛ مورد بررسی قرار گرفت. به منظور دستیابی به متن کامل مقاله هایی که از کلید واژه های فارسی؛ پریشانی اخلاقی، تنیدگی اخلاقی، تنش اخلاقی، دیسترس اخلاقی، اضطراب اخلاقی، آشفتگی اخلاقی و عبارات مرتبط با اورژانس به صورت ترکیب واژگان استفاده گردید؛ همچنین از روش های جستجوی بولین و عملگرهای And و OR و کلید واژه های MeSH &nbsp;شامل؛&nbsp; Moral Distress, Ethical Distress, Ethical unease, Ethical disquiet, Emergency &nbsp;استفاده&nbsp; شد. یافته ها: در مرحلۀ اولیه، 466 تحقیق مورد مطالعه و بررسی قرار گرفت. سپس پژوهشگران به بررسی مقاله هایی که جستجو شده بود پرداختند و در نهایت پس از حذف موارد تکراری، نامرتبط، مطالعات کیفی، مرور روایتی و نامه به سردبیر؛ 18 تحقیق در جهت نگارش این پژوهش، استفاده گردید. از میان مطالعه های مورد بررسی، محل انجام 11 مقاله ایران بود که 11/61 دصد کل مطالعات را نشان میدهد؛ سایر مطالعات در تایوان، چین، آمریکا، اندونزی و سوئیس انجام شده است. میانگین پریشانی اخلاقی پرستاران بخش اورژانس در سطح متوسط و ارتباط معنادار با مولفه هایی همچون سابقه و حجم کار از یافته های این مطالعات بود. نتیجه گیری: مجموعه مطالعات انجام شده بر روی پرستاران بخش اورژانس، برای نشان دادن میزان پریشانی اخلاقی تعداد قابل اطمینانی می باشد، اما این میزان مطالعه برای دستیابی به الگویی از مولفه ها و متغیر های مرتبط با پریشانی اخلاقی، قابل اطمینان نیست. برای این منظور علاوه بر پژوهش های بیشتر بر روی این گروه از پرستاران، می توان با الغای خصوصیت از پرستاران بخش اورژانس، مروری نظام مند بر کل مطالعات انجام شدر در زمینه پریشانی اخلاقی بر روی جامعه پرستاری انجام داد تا به نتایج دقیق تری دست یافت