2 research outputs found
Determination of sparļ¬oxacin and besiļ¬oxacin hydrochlorides using gold nanoparticles modiļ¬ed carbon paste electrode in micellar medium
A gold nanoparticles modiļ¬ed carbon paste electrode (AuCPE) was used to study the electrochemical behavior of sparļ¬oxacin HCl (SPAR) and besiļ¬oxacin HCl (BESI) using cyclic and diļ¬erential pulse voltammetry modes in the presence of micellar medium. Eļ¬ect of diļ¬erent surfactants on peak current was studied in BrittonāRobinson buļ¬er solution of pH 2. Sodium dodecyl sulphate is the optimum surfactant based on the enhancement of the peak current. The modiļ¬ed electrode shows highly sensitive sensing giving an excellent response for SPAR and BESI. The peak current varied linearly over the concentration ranges from 1.1 10 7 mol L 1 to 3.3 10 6 mol L 1 and from 2.2 10 to 5.5 10 5 mol L 1 with determination coeļ¬cients of 0.9976 and 0.9984 in case of SPAR and BESI, respectively. The recoveries and the relative standard deviations were found in the following ranges: 99.97ā101.4% and 0.63ā1.48% for SPAR and 99.89ā101.1% and 0.85ā1.76% for BESI. The detections limits were 2.87 10 8 and 3.76 10 7 mol L 1 for SPAR and BESI, respectively. The proposed method has been successfully applied to determine SPAR and BESI in biological ļ¬uids
Determination of sparfloxacin and besifloxacin hydrochlorides using gold nanoparticles modified carbon paste electrode in micellar medium
A gold nanoparticles modified carbon paste electrode (AuCPE) was used to study the electrochemical behavior of sparfloxacin HCl (SPAR) and besifloxacin HCl (BESI) using cyclic and differential pulse voltammetry modes in the presence of micellar medium. Effect of different surfactants on peak current was studied in BrittonāRobinson buffer solution of pH 2. Sodium dodecyl sulphate is the optimum surfactant based on the enhancement of the peak current. The modified electrode shows highly sensitive sensing giving an excellent response for SPAR and BESI. The peak current varied linearly over the concentration ranges from 1.1 Ć 10ā7 mol Lā1 to 3.3 Ć 10ā6 mol Lā1 and from 2.2 Ć 10ā6 mol Lā1 to 5.5 Ć 10ā5 mol Lā1 with determination coefficients of 0.9976 and 0.9984 in case of SPAR and BESI, respectively. The recoveries and the relative standard deviations were found in the following ranges: 99.97ā101.4% and 0.63ā1.48% for SPAR and 99.89ā101.1% and 0.85ā1.76% for BESI. The detections limits were 2.87 Ć 10ā8 and 3.76 Ć 10ā7 mol Lā1 for SPAR and BESI, respectively. The proposed method has been successfully applied to determine SPAR and BESI in biological fluids