10 research outputs found
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HendrixDavidEECSPRC2RequiredMaintainSupplementalInformationFiguresS1–S7andTablesS1–S7.pdf
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No full textPolycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence of PRC2, the entire locus becomes transcriptionally repressed due to gain of DNAme at the intergenic differentially methylated regions (IG-DMRs). Furthermore, we demonstrate that the IG-DMR serves as an enhancer of the maternal Gtl2-Rian-Mirg locus. Further analysis reveals that PRC2 interacts physically with Dnmt3 methyltransferases and reduces recruitment to and subsequent DNAme at the IG-DMR, thereby allowing for proper expression of the maternal Gtl2-Rian-Mirg locus. Our observations are consistent with a mechanism through which PRC2 counteracts the action of Dnmt3 methyltransferases at an imprinted locus required for full pluripotency
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HendrixDavidEECSPRC2RequiredMaintain.pdf
- Publication venue
- Publication date
- Field of study
No full textPolycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence of PRC2, the entire locus becomes transcriptionally repressed due to gain of DNAme at the intergenic differentially methylated regions (IG-DMRs). Furthermore, we demonstrate that the IG-DMR serves as an enhancer of the maternal Gtl2-Rian-Mirg locus. Further analysis reveals that PRC2 interacts physically with Dnmt3 methyltransferases and reduces recruitment to and subsequent DNAme at the IG-DMR, thereby allowing for proper expression of the maternal Gtl2-Rian-Mirg locus. Our observations are consistent with a mechanism through which PRC2 counteracts the action of Dnmt3 methyltransferases at an imprinted locus required for full pluripotency
ＣＤ４｀＋´ＣＤ２５｀＋´制御性Ｔ細胞が及ぼす関節リウマチ疾患活動性への影響
- Author
- Publication venue
- 'Japan Society for Clinical Immunology'
- Publication date
- 01/01/2006
- Field of study
No full textPositional cloning of the Fanconi anaemia group A gene
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- Publication venue
- Publication date
- 01/01/1996
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No full textPositional cloning of the Fanconi anaemia group A gene
- Author
- Publication venue
- Publication date
- 01/01/1996
- Field of study
No full textRole of Endoscopic Ultrasound in Gastroenteropancreatic Neuroendocrine Tumors and Update on Their Treatment
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- Publication venue
- 'Jaypee Brothers Medical Publishing'
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No full textPrinciples of Clinical Pathology for Toxicology Studies
- Author
- Apostolou A
- Beguin Y.
- Beutler E.
- Bovee KC
- Burtis CA
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- Chanter DO
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- Defining BF
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- Kaushansky K
- Keller P
- Kimball JP
- Knoll JS.
- Kurata M
- Maejima K
- Martin RA
- Matsuzawa T
- McGrath JP
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- Millis DL
- Packman CH
- Passey RB.
- Rebar AH
- Roncaglioni MC
- Schardijn GH
- Schiffer SP
- Sherwin JE
- Stromberg PC.
- Sturgill MG
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- Publication venue
- 'Informa UK Limited'
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No full textSelenium-Enriched Saccharomyces cerevisiae Reduces the Progression of Colorectal Cancer
- Author
- A Giatromanolaki
- A Yemelyanova
- Ahmad Yari Khosroushahi
- AL Sesink
- Amir Tukmechi
- B Magnuson
- C Caruso
- C Ip
- CM Fenoglio-Preiser
- DD Gallaher
- E Laas
- E McLellan
- ET Jacobs
- F Bolognani
- G Apostolou
- H Steinbrenner
- H Thomadaki
- H Xiao
- H Zeng
- H Zeng
- I Rowland
- J Lu
- Jamileh Abedi
- JG Teodoro
- JG Teodoro
- JJ Bauer
- JW Finley
- K Ortman
- K Yip
- KT Bieging
- L He
- LA Henríquez-Hernández
- M Campbell-Thompson
- M Ochiai
- M Sengottuvelan
- M-H Xu
- Maedeh Vakili Saatloo
- ME Sanders
- MP Rayman
- MP Rayman
- OO Hamiza
- P Vermeulen
- PA Muller
- Q Ma
- Rahim Hobbenaghi
- RP Bird
- S Zinkel
- T Maseko
- TP Pretlow
- Vahid Nejati
- W Chen
- Yousef Nami
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- 'Springer Science and Business Media LLC'
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No full textPancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- ?tinas A
- Aalem HAA
- Ababneh H
- Abbas A
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- Abbas H
- Abbasi A
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- Abbood AH
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- Abdelmawgoud S
- Abdelmawla M
- Abdelmawla MOMK
- Abdelmoneim N
- Abdelnoor A
- Abdelrahman F
- Abdelrazek HA
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- Abdelzaher A
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- Abdou K
- Abdoun M
- Abdualqader M
- Abdualqader MYM
- Abdulhaq A
- Abduljawad H
- Abdullaev A
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- Abiyere H
- Abobakr AM
- Aboelfath S
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- Abu Hilal M
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- Abuali ASAME
- Abuelazm M
- Abuelnaga Y
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- Abughazal SY
- Abuleil A
- Abusannuga M
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- Adham M
- Adhikari KM
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- Afzal A
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- Aghdassi A
- Ahmadi BE
- Ahmed EA
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- Ahmed R
- Ahmeed
- Ajayi P
- Akahoshi K
- Akbar A
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- Al-Abdi R
- Al-Abed O
- Al-Ameri S
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- Al-Dowsh NA
- Al-Eryani F
- Al-Faiq S
- Al-Haj A
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- Al-juaifari MA
- Al-Khawlani Q
- Al-Kubati W
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- Al-Mallah R
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- Al-Melhani W
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- Publication venue
- Publication date
- 18/01/2024
- Field of study
No full textRegulatory T-Cell Differentiation and Their Function in Immune Regulation
- Author
- A Banerjee
- A Cebula
- A Chaudhry
- A Curti
- A Kitani
- A Liston
- A Marson
- A Saoudi
- A Sledzinska
- A Teles
- AC Seale
- AE Herman
- AL Putnam
- AL Szymczak-Workman
- AM Beebe
- AM Bilate
- AM Khalil
- AV Bazhin
- B Sadlack
- B Sadlack
- B Salomon
- B Valzasina
- B Yan
- BD Sather
- BH Nelson
- C Govindaraj
- C Schmidl
- C Tanchot
- C Xufre
- CA Akdis
- CA Chambers
- CG Brunstein
- CL Bennett
- CS Hsieh
- CW Lio
- D Adeegbe
- D Burzyn
- D Burzyn
- D Cipolletta
- D Mucida
- D Olivares-Villagomez
- D Rudra
- DA Somerset
- DA Wainwright
- DP Bartel
- DQ Tran
- DT Patton
- E Bettelli
- E Elkord
- E Etemire
- EA Tivol
- EM Shevach
- ES Sobel
- EY Lyssuk
- F Fallarino
- G Liao
- G Wei
- G Zhou
- GC Furtado
- GL Stephens
- GT Macfarlane
- H Bagavant
- H Groux
- H Guo
- H Hata
- HJ Park
- HM Santen van
- HP Kim
- I Apostolou
- I Isomura
- IJ Suffia
- J Bodor
- J Mestecky
- J Qin
- J Shimizu
- J Wang
- J Wong
- J Yates
- JC Crispin
- JD Fontenot
- JD Fontenot
- JH Cho
- JH Peters
- JL Suen
- JM Kim
- JP Hindley
- K Atarashi
- K Atarashi
- K Kretschmer
- K Lahl
- K Nakamura
- K Nakamura
- K Sell
- K Wing
- KC Wang
- KJ Scalapino
- KL Laurie
- L Demir
- L Fohse
- L Lu
- LF Lu
- LF Lu
- LR Leon
- LT Nguyen
- LW Collison
- LW Collison
- LY Hsu
- M Battaglia
- M Feuerer
- M Feuerer
- M Gobert
- M Goerner
- M Hinterberger
- M Ianni Di
- M Itoh
- M Kornete
- M Miyara
- M Miyara
- M Papiernik
- M Schmidt-Supprian
- M Turner
- M Viguier
- M Yadav
- MA Curotto de Lafaille
- MA Curotto de Lafaille
- MA Gavin
- MA Koch
- MA Linterman
- MB Datto
- MC Fantini
- MI Vargas-Rojas
- MJ Barnes
- MK Racke
- MM Chong
- MR Friedlander
- MS Jordan
- N Gagliani
- N Marek-Trzonkowska
- N Ohkura
- OM Siggs
- P Bedner
- P Hoffmann
- P Jailwala
- P Pandiyan
- P Pandiyan
- P Trzonkowski
- PA Savage
- PY Mantel
- Q Ruan
- R Bacchetta
- R Khattri
- R Pacholczyk
- R Pacholczyk
- R Rouas
- RA Gottschalk
- RK Venigalla
- RM Samstein
- RM Samstein
- RS McHugh
- RS Wildin
- RS Wildin
- RT Gazzinelli
- S Barath
- S Deaglio
- S Floess
- S Glisic-Milosavljevic
- S Gupta
- S Hori
- S Hori
- S Koonpaew
- S Ladoire
- S Loewer
- S Makita
- S Onizuka
- S Ostman
- S Rao
- S Read
- S Ronchetti
- S Sattui
- SC Lin
- SD Marks
- SE Allan
- SG Zheng
- SG Zheng
- SG Zheng
- SJ Patterson
- SJ Zunino
- SK Lathrop
- SS Zhao
- SZ Lin
- T Bopp
- T Brusko
- T Duhen
- T Hayashi
- T Hung
- T Takahashi
- TA Chatila
- TJ Curiel
- TL Whiteside
- U Baron
- U Grohmann
- U Grohmann
- VC Liu
- W Chen
- W Liu
- W Ouyang
- W Ouyang
- W Yang
- WT Hsu
- X Liu
- X Tai
- X Valencia
- X Zhou
- Y Chung
- Y Furusawa
- Y Onishi
- Y Shi
- Y Zheng
- Y Zheng
- Y Zheng
- YM Kerdiles
- YP Rubtsov
- YQ Qiao
- YY Wan
- YY Wan
- Zhan Y Funda DP et al
- ZZ Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full text
