PENGARUH INTERGOVERNMENTAL REVENUE DAN VALUE ADDED HUMAN CAPITAL TERHADAP KINERJA KEUANGAN PEMERINTAH DAERAH

ABSTRAK             Penelitian ini bertujuan untuk menguji pengaruh intergovermental revenue dan value added human capital terhadap kinerja keuangan instansi pemerintah daerah. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan penelitian korealasional untuk  menguji pengaruh variabel independen terhadap variabel dependen. Populasi dalam penelitian ini adalah laporan keuangan instansi pemerintah yang terdapat di Sulawesi Selatan. Pada penelitian ini dilakukan pengujian parsial antara pengaruh intergovermental revenue terhadap kinerja keuangan instansi pemerintah daerah yang menemukan bahwa intergovermental revenue berpengaruh negatif dan signifikan terhadap kinerja keuangan instansi pemerintah daerah.Pengujian kedua dalam penelitian ini untuk menguji pengaruh value added human capital terhadap kinerja keuangan instansi pemerintah daerah. Hasil pengujian ini menemukan bahwa value added human capital berpengaruh positif dan signifikan terhadap kinerja keuangan instansi pemerintah daerah. ABSTRACT This research aims to examine the influence of intergovernmental revenue and value added human capital on the financial performance of local government agencies. This research uses qualitative research methods with a correlational research approach to test the influence of independent variables on the dependent variable. The population in this study is the financial statements of government agencies in South Sulawesi. In this research, a partial test was carried out between the influence of intergovernmental revenue on the financial performance of local government agencies, which found that intergovernmental revenue had a negative and significant effect on the financial performance of local government agencies. The second test in this research was to test the effect of value added human capital on the financial performance of local government agencies. The results of this test found that value added human capital has a positive and significant effect on the financial performance of local government agencies

The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?

Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. Recent investigations have identified co-operating mutations in the RAS pathway and although the functional consequences of these mutations are not yet fully understood, aberrant regulation of RAS pathway signalling at both transcriptional and protein levels is observed. Studies investigating the efficacy of specific inhibitors of this pathway, e.g. MEK-inhibitors, have also achieved encouraging results. In this context, this mini-review summarizes the available data surrounding MLL-r infant ALL with RAS mutation in relation to other well-known features of this intriguing disease

Gut-microbiota link in Parkinson’s disease: current perspectives

Parkinson’s disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) in the substantia nigra in the central nervous system(CNS).Contributory factors include pesticide exposure, head injury and agriculture background. PD has been considered to be a non-genetic disorder, however around 15% individuals with PD have firstdegree relative who has the disease Mutations in genes including SNCA,LRRK2 and gluococerebrosidase (GBA) found to be risk factor for sporadic PD. Brain cells could be lost due to an abnormal accumulation of the protein alpha-synculein.This insoluble protein accumulates inside neurons forming inclusions called Lewy bodies. Other cell death mechanisms include proteasomal and lysosomal system dysfunction, but the mechanisms are not fully understood. Brain –gut axis(GBA) refers to central nervous system(CNS) control of the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate the neurodegenerative changes in PD are accompanied by gastrointestinal symptoms that may precede or follow the central nervous systemimpairment. Frequent symptoms in PD include tremor, rigidity, slowness of movement and difficulty with walking. Treatment with L-DOPA(levodopa),with dopamine agonist, medications become less effective and produce complications. Research studies recommend new therapeutic approach in PD based on modification of the gut microbiota with probiotics, prebiotics, or even fecal microbiota transplantation

A negative screen for mutations in calstabin 1 and 2 genes in patients with dilated cardiomyopathy

<p>Abstract</p> <p>Background</p> <p>Calstabins 1 and 2 bind to Ryanodine receptors regulating muscle excitation-contraction coupling. Mutations in Ryanodine receptors affecting their interaction with calstabins lead to different cardiac pathologies. Animal studies suggest the involvement of calstabins with dilated cardiomyopathy.</p> <p>Results</p> <p>We tested the hypothesis that calstabins mutations may cause dilated cardiomyopathy in humans screening 186 patients with idiopathic dilated cardiomyopathy for genetic alterations in calstabins 1 and 2 genes (<it>FKBP12 </it>and <it>FKBP12.6)</it>. No missense variant was found. Five no-coding variations were found but not related to the disease.</p> <p>Conclusions</p> <p>These data corroborate other studies suggesting that mutations in <it>FKBP12 </it>and <it>FKBP12.6 </it>genes are not commonly related to cardiac diseases.</p