THE PRINCIPLES OF PRIMARY PROPHYLAXIS OF ALLERGIC DISEASES WITH DIET IN CHILDREN

The increase of prevalence of allergic diseases makes specialists for developing of new methods of primary prophylaxis. This article presents modern approach to opportunities of primary prophylaxis of allergic diseases with diet in children.Key words: alimentary allergy, children, prophylaxis, allergic diseases.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(3):123-126

INITIAL ALLERGY PREVENTION IN CHILDREN

Allergy prevention is an urgent pediatric issue. Food allergy spread among infants amounts to 6–8%. This review highlights the modern viewpoints on diet prevention of this pathology among children, including by means of the hypoallergic nutritional formulas.Key words: food allergy, prevention, allergies, prebiotics, children

INITIAL ALLERGY PREVENTION IN CHILDREN

Allergy prevention is an urgent pediatric issue. Food allergy spread among infants amounts to 6–8%. This review highlights the modern viewpoints on diet prevention of this pathology among children, including by means of the hypoallergic nutritional formulas.Key words: food allergy, prevention, allergies, prebiotics, children

ANTIMYCOTIC ACTIVITY OF ACTIVATED ZINC PYRITHIONE IN RELATION TO MALASSEZIA IN PATIENTS WITH ATOPIC DERMATITIS

The article illustrates the results of a study whose purpose was to determine the antimycotic action of activated zinc pyrithione (AZP) against Malassezia in patients with atopic dermatitis (AD). 30 patients diagnosed with AD and aged 3 to 18 years were studied. A mycological study that aimed to identify Malassezia was done by the scraping method and skin surface collection using a cotton ball on a 1 cm2 area, with further yeast maintenance procedure in a selective environment. The activated zinc pyrithione in the form of cream was applied on children’s skin of the left shoulder and forearm twice a day. Nothing but a moisturizing cream was applied to the skin on the right shoulder and forearm. The samples for mycobiota were taken on both sides three times: before AZP treatment, 1 and 2 weeks after treatment. As a result of treatment, a two-fold reduction in skin colonization with Malassezia just in a week’s time (up to 102–105 КОЕ/cm2). The significant dynamics was observed in the modification of species diversity which got more sparse in skin areas where activated zinc pyrithione cream was applied. The follow-up results confirm that AZP has a moderate antimycotic effect. Key words: atopic dermatitis, treatment, activated zinc pyrithione, antimycotic action, children. (Pediatric Pharmacology. – 2010; 7(6):58-62

Evidence for clinical safety, efficacy, and parent and physician perceptions of levocetirizine for the treatment of children with allergic disease

Allergic rhinitis (AR) and chronic idiopathic urticaria (CIU) are highly burdensome diseases, which are increasing in prevalence, especially in the paediatric population. Despite the availability of a large number of medications for treatment of AR and CIU, their use in children has primarily been based on data obtained from a limited number of clinical trials in children and/or testing in adults. The H1-antihistamines have traditionally been used as first-line treatment for the relief of both AR and CIU symptoms in children. The first-generation H1-antihistamines are associated with marked adverse effects such as sedation, sleepiness/drowsiness as well as difficulties in learning and cognitive processing; thus, they are recommended for limited or discontinued use in children with AR or CIU. In contrast, second-generation H1-antihistamines are more adapted for the use in children with AR and CIU due to better safety profiles. However, only a limited number of trials with these agents have been conducted and generally, data from well-designed trials in children are lacking. Levocetirizine is one of the most extensively investigated H1-antihistamines for its pharmacologic properties, safety, efficacy as well as overall global satisfaction in children aged 2-12 years. Levocetirizine is the only H1-antihistamine launched in the 21st century shown to lack clinically relevant adverse effects on physical and psychomotor development or routine laboratory tests over a long-term period of 18 months in 1- to 3-year-old children predisposed to development of allergic disease. Available data suggest that levocetirizine is a suitable treatment option for AR and CIU in children aged 6 months to 12 years. Copyright © 2011 S. Karger AG, Basel

ANTIMYCOTIC ACTIVITY OF ACTIVATED ZINC PYRITHIONE IN RELATION TO MALASSEZIA IN PATIENTS WITH ATOPIC DERMATITIS

The article illustrates the results of a study whose purpose was to determine the antimycotic action of activated zinc pyrithione (AZP) against Malassezia in patients with atopic dermatitis (AD). 30 patients diagnosed with AD and aged 3 to 18 years were studied. A mycological study that aimed to identify Malassezia was done by the scraping method and skin surface collection using a cotton ball on a 1 cm2 area, with further yeast maintenance procedure in a selective environment. The activated zinc pyrithione in the form of cream was applied on children’s skin of the left shoulder and forearm twice a day. Nothing but a moisturizing cream was applied to the skin on the right shoulder and forearm. The samples for mycobiota were taken on both sides three times: before AZP treatment, 1 and 2 weeks after treatment. As a result of treatment, a two-fold reduction in skin colonization with Malassezia just in a week’s time (up to 102–105 КОЕ/cm2). The significant dynamics was observed in the modification of species diversity which got more sparse in skin areas where activated zinc pyrithione cream was applied. The follow-up results confirm that AZP has a moderate antimycotic effect. Key words: atopic dermatitis, treatment, activated zinc pyrithione, antimycotic action, children. (Pediatric Pharmacology. – 2010; 7(6):58-62

CLINICAL EFFICIENCY OF ZINC PYRITHIONE TO TREAT ATOPIC DERMATITIS IN CHILDREN

Atopic dermatitis is one of the most widespread children’s diseases, it has a chronic recurrent clinical course, may be often complicated with the secondary infection. This necessitates the choice of a medication to impact all stages of the disease process with a high safety profile. This digest is devoted to activated zinc pyrithione. Overall, currently available data make it possible to state that this agent is one of the most effective and safest products to be used for a local therapy of atopic dermatitis in children. Key words: atopic dermatitis, activated zinc pyrithione, childre

CLINICAL EFFICIENCY OF LEVOCETIRIZINE IN CHILDREN WITH SEASONAL ALLERGIC RHINITIS AND ITS IMPACT ON THE QUANTITATIVE COMPOSITION AND MORPHOLOGICAL INDICATORS OF EOSINOCYTES IN PERIPHERAL BLOOD

Allergic pathology is widely spread among children. In order to perform an adequate therapy and minimize the risk of the side effects, it is essential to develop a differentiated approach of the practitioners towards the prescription of medications in view of their action on the pathological process, interaction with other medications, safety and efficiency data subject to the principles of the definitive medicine. The present article highlights the results of the clinical research of the second'generation antihistamine levocetirizine administration in the allergic rhinitis in children.Key words: allergic rhinitis, antihistamine medications, levocetirizine, action, efficiency, children