Исходы новой коронавирусной инфекции COVID-19 у 68 пациентов с воспалительными заболеваниями кишечника

Background. COVID-19 is an infectious respiratory syndrome with a wide range of manifestations and outcomes. Patients with inflammatory bowel disease (IBD) generally have a higher risk of infection, especially if they receive immunosuppressive therapy. Aim to describe the manifestations of COVID-19 in patients with IBD and to determine the risk factors for severe COVID-19. Methods. The analysis included 68 patients with an established diagnosis of Crohns disease (CD) or ulcerative colitis and a confirmed new coronavirus infection. The diagnosis of coronavirus infection was established when SARS-CoV-2 was detected by PCR using nasopharyngeal smears, and computer tomography (CT) of the chest revealed inflammatory changes characteristic of coronavirus lung damage or high IgG and IgM titers based on the results of immunological blood analysis. Results. 68 patients with IBD and COVID-19 were observed in the Department of IBD, including 27 (39.7%) patients with CD, 41 (60.3%) patients with UC. Among patients diagnosed with pneumonia, 100 % of patients received therapy with thiopurines and infliximab. 8 (11.8%) patients were diagnosed with COVID-19 during hospitalization for a severe IBD attack. There was no statistically significant difference between UC and CD patients in terms of disease activity (p = 0.13) during the period of coronavirus infection. In 37 patients (26 UC, 11 BC) with pneumonia (100%), there was an exacerbation of IBD. Statistical significance was found between the development of more severe lung damage (CT 34) and IBD activity at the time of diagnosis of COVID-19 (p 0.001), the presence of comorbidities (p 0.001) and taking GCS (p 0.001) at the time of detection of COVID-19. However, the use of biological and immunosuppressive therapy was not associated with a higher risk of severe lung damage and the need for a ventilator. It was shown that the age of patients over 65 years was statistically correlated with the need for a ventilator (p = 0.02). Conclusion. The exacerbation of the disease, especially in elderly patients with comorbidities, the use of glucocorticosteroids was associated with negative consequences of COVID-19, while biological and immunosuppressant drugs used for the treatment of IBD did not have such a negative effect.Обоснование. COVID-19 это инфекционный респираторный синдром с широким спектром проявлений и исходов. Пациенты с воспалительными заболеваниями кишечника (ВЗК) имеют больший риск инфицирования SARS-CoV-2, в особенности если они получают иммуносупрессивную терапию. Цель исследования описать проявления COVID-19 у пациентов с ВЗК и определить факторы риска тяжелого течения COVID-19. Методы. В анализ были включены 68 пациентов c установленным диагнозом болезни Крона (БК) или язвенного колита (ЯК) и подтвержденной новой коронавирусной инфекцией. Диагноз коронавирусной инфекции устанавливался при выявлении SARS-CoV-2 методом ПЦР назофарингеальных мазков, выявлении при компьютерной томографии (КТ) органов грудной клетки воспалительных изменений, характерных для коронавирусного поражения легких, или высокого титра IgG и IgM по результатам иммунологического анализа крови. Результаты. 68 пациентов с ВЗК и COVID-19 наблюдались в отделении лечения Московского клинического научно-практического центра имени А.С. Логинова, из них 27 (39,7%) пациентов с БК, 41 (60,3%) пациент с ЯК. Не было выявлено статистически значимого различия между пациентами ЯК и БК в отношении активности заболевания (p = 0,13) в период коронавирусной инфекции. У 37 пациентов (26 с ЯК, 11 с БК) с пневмонией (100%) имелось обострение ВЗК. У 8 (11,8%) пациентов был диагностирован COVID-19 во время госпитализации по поводу тяжелой атаки ВЗК. Была выявлена статистическая значимость между развитием более тяжелого поражения легких (КТ 34) и активностью ВЗК на момент диагностирования COVID-19 (p 0,001), наличием сопутствующих заболеваний (p 0,001) и приемом ГКС (p 0,001) на момент выявления COVID-19. При этом применение биологической и иммуносупрессивной терапии не было связано с более высоким риском тяжелого поражения легких и потребностью в ИВЛ. Было показано, что возраст пациентов более 65 лет статистически коррелировал с потребностью в ИВЛ (p = 0,02). Заключение. Обострение заболевания, в особенности у пожилых пациентов с сопутствующей патологией, и прием глюкокортикостероидов имели зависимость с негативными последствиями COVID-19, в то время как препараты биологической и иммуносупрессорной терапии, применяемые для лечения ВЗК, не оказывали такого негативного влияния

Особенности функционирования медиапространства Казахстана в условиях глобализации

This article is devoted to the study of the functional features of the media space in Kazakhstan under the rapidly changing globalization trends and information confrontation of world powers. Since gaining independence, Kazakhstan is striving to create its own independent information space. The process of information space formation in the country has several traits, such as low competitiveness of national news agencies, slow development of the regulatory and legal framework in the field of information security, high politicization, including the language issue. These features occurred due to the heterogeneous language environment, the problems of the formation of national independent news agencies, the challenges of globalization, the most pressing of which is the growing influence of global media. In this article, authors touch upon the transition of Kazakhstan to the Latin alphabet, as well as the views of Western, Russian and Kazakhstan researchers on the current state of the media landscape of Kazakhstan. Authors justify the need to work out ways to minimize external information impact on the media landscape of Kazakhstan that is still undergoing media transformation processes.Статья посвящена исследованию медиапространства Республики Казахстан в условиях стремительно меняющихся глобализационных трендов и информационного противостояния мировых держав. С момента получения независимости Казахстан стремится к созданию собственного независимого информационного пространства. Этот процесс имеет ряд особенностей, таких как низкая конкурентоспособность национальных информационных агентств, медленное развитие нормативно-правовой базы в сфере обеспечения информационной безопасности, высокая политизированность, в том числе и в языковом вопросе, что обусловлено неоднородной языковой обстановкой, проблемами формирования национальных независимых информационных агентств, вызовами глобализации, самым актуальным из которых является растущее влияние глобальных СМИ. В статье затрагивается вопрос перехода Казахстана на латиницу, а также взгляды западных, российских и казахстанских исследователей на современное состояние медиапространства Казахстана. Обосновывается необходимость выработки путей минимизации внешнего информационного влияния на медиапространство Казахстана, которое все еще находится на этапе цифровой трансформации

Plasma-Sprayed Manganese-Containing Tricalcium Phosphate Coatings on Titanium

Abstract—: Manganese-substituted tricalcium phosphates (TCPs), Ca3(PO4)2, containing 0–1.49 wt % manganese have been prepared by heterophase synthesis using mechanical activation. The percentage of manganese has been determined by inductively coupled plasma atomic emission spectroscopy and atomic absorption spectroscopy. The compounds have been characterized by X-ray diffraction, IR spectroscopy, EPR spectroscopy, and scanning electron microscopy (SEM). Ceramic coatings have been produced using an arc plasma source. The coatings have been characterized by X-ray diffraction and SEM with the use of energy dispersive X-ray analysis. They have been shown to consist of α-TCP and hydroxyapatite (Ca10(PO4)6(OH)2). Manganese ions have been shown to be incorporated into the crystal lattice of TCP. After holding in physiological solution at pH 7.4 for 90 days, neither manganese nor phosphorus was detected in the coatings. After holding in physiological solution, the coatings consisted of calcium carbonate, as was demonstrated by energy dispersive X-ray analysis. The coatings produced on titanium implants are promising for use in orthopedics and dentistry

Composite polyvinylpyrrolidone–sodium alginate—Hydroxyapatite hydrogel films for bone repair and wound dressings applications

Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymer PVP-SA blend. The developed composite hydrogel films are recommended for such applications, such as membranes in osteoplastic surgery and wound dressing

Domanic deposits of the Volga-Ural basin – types of section, formation conditions and prospects of oil and gas potential

The Domanic deposits of the Volga-Ural oil and gas basin are a high-carbon thin-bedded formation capable of both producing hydrocarbons with its own oil and gas bearing strata and concentrating them in separate reservoirs and zones (Stoupakova et al., 2015). Formation of the Domanic deposits occurred in a relatively deep basin, during the filling of which a variety of sedimentation environments arose from relatively deep sea to shallow-marine. The peculiarity of the formation conditions of high-carbon strata is the increased content of organic matter, carbonate material and free silica, the source of which could be hydrotherms or volcanogenic products, creating a special gas regime of the Earth’s atmosphere in the late Devonian. Evaluation of the generation potential of the Domanic formation showed that siliceous-carbonate and carbonate-siliceous rocks enriched with marine algal organic matter have a high potential. The greatest prospects of oil bearing are the deflections formed on the site of the avlakogen and their slopes, where deposits, rich in organic matter, were formed practically throughout the late Devonian-Tournaisian. High prospects have slopes of uplifts or sides of reef bodies. Such incisions are distributed on the sides of troughs of uncompensated immersion and the lower parts of uplift slopes adjacent to them. In the domanonicoid deposits, in which the carbonate material predominates, the high-carbon intervals developed along the biohermic structures

Taphonomic phenomenon of ancient hair from Glacial Beringia: perspectives for palaeoecological reconstructions

Bioarchaeolog