Активные производные D-галактозы и D-лактозы в синтезе неогликоконъюгатов

Synthesis of active derivatives of carbohydrates D-galactose and D-lactose and neoglycoconjugates on their basis is carried out. For receiving modified glycolipids the approach with use N-hydroxysuccinimide ethers of carbohydrates is offered.Осуществлён синтез активных производных углеводов D-галактозы и D-лактозы и неогликоконъюгтов на их основе. Для получения модифицированных гликолипидов предложен подход с использованием N- гидроксисукцинимидных эфиров углеводов

ИНТЕГРАТИВНЫЕ ОСНОВЫ АЛЕКСИТИМИИ

The aim of the study was to show the interrelation between the gradually increasing alexithymia traits and the integrative self regulation style of emotional, personal and cognitive interaction with the environment. The Toronto Alexithymia scale was used for examination of 356 students of a medical university. The students were divided into 4 groups in accordance with the alexithymia degree (69 - 94 scores for a high degree). The integral methods of estimation of an individuality were: Temperament Traits Accentuation, Differential estimation of Personal anxiety, Property Concept Discrimination and Copying Strategy. We noticed that the higher was the alexithymia degree the more marked was accentuation of asthenic temperament traits (emotional instability, social and objective passivity) and of personal anxiety (neural-psychic excitability and shyness). There was prevalence of inadaptive copying strategies and abstractive self-controlling style of intellectual activity. Alexithymia is the integral psychological phenomenon combining emotional, volutional, personal and mental parameters of an individuality as a whole. The structure of the phenomenon allows existence of different variants of the components and hence of its typology - the fact of scientific and practical value.Цель работы: выявить взаимоотношения между нарастающими градациями алекситимии и интегральными параметрами индивидуальности, проявляющимися в стиле саморегуляции эмоционального, личностного и когнитивного взаимодействия с реальностью. 356 студентов медицинского университета оценивали по Торонтской шкале алекситимии и разделили на 4 группы по степени ее выраженности, при высокой с числом баллов 69 - 94. Применены интегральные методы исследования индивидуальности - тесты акцентуации свойств темперамента, дифференцированной оценки личностной тревожности, дискриминации свойств понятий и определения копинг-стратегий. Установлено, что чем выше степень алекситимии, тем больше выражена акцентуация астенических свойств темперамента (эмоциональная нестабильность, социальная и предметная пассивность), а также уровень личностной тревожности (особенно факторов нервно-психической возбудимости и застенчивости в ее структуре). Отмечено также нарастание числа неадаптивных копинг-стратегий и предпочтение абстрактного стиля саморегуляции интеллектуальной деятельности. Алекситимия - интегральный психологический феномен, сопрягающий эмоционально-волевые, личностные, ментальные параметры индивидуальности в единое целое. В структуре этого феномена можно предполагать существование различных вариантов соотношения компонентов и, следовательно, его типологии, что может иметь научное и практическое значение

L-Lysine as the Molecule Influencing Selective Brain Activity in Pain-Induced Behavior of Rats

Lysine-rich proteins are some of the most important proteins of neurons and it has become necessary to investigate the possible role of L-lysine as a brain functioning regulator. The purpose of our study is to identify the characteristics and the mechanisms of L-lysine effects on the different types of pain-induced behavior in the stimulation of tail and foot-shock models in 210 adult male Wistar rats. L-lysine was administered in intraperitoneal or intracerebroventricular injections in doses of 0.15–50.0 µg/kg. When a tail is irritated, L-lysine was found to enhance pain sensitivity and affective defense after both intraperitoneal and intracerebroventricular administration. In the case of unavoidable painful irritation of a pair of rats with both types of L-lysine administration, there was no direct correlation of the severity of pain with defensive reactions and outbursts of aggression. This indicates a more complex integration of the activity of brain structures in this situation of animal interaction, which was confirmed by the results of the direct amino acid action on the periventricular brain structures. Our findings show that L-lysine influences the selective brain activity in dependence on the biological significance of pain-induced behavior

State corporation: subject with special legal status

This article deals with the legal status of State Corporation in comparison with the legal status of the JSC. The authors accent unique and specific characteristics of State Corporation, analyze its creation procedure and liquidation . They also evaluate advantages and disadvantages of this legal form of organization

Active derivatives based on D-galactose and D-lactose in synthesis of neoglycoconjugates

Synthesis of active derivatives of carbohydrates D-galactose and D-lactose and neoglycoconjugates on their basis is carried out. For receiving modified glycolipids the approach with use N-hydroxysuccinimide ethers of carbohydrates is offered

L-Lysine as the Molecule Influencing Selective Brain Activity in Pain-Induced Behavior of Rats

Lysine-rich proteins are some of the most important proteins of neurons and it has become necessary to investigate the possible role of L-lysine as a brain functioning regulator. The purpose of our study is to identify the characteristics and the mechanisms of L-lysine effects on the different types of pain-induced behavior in the stimulation of tail and foot-shock models in 210 adult male Wistar rats. L-lysine was administered in intraperitoneal or intracerebroventricular injections in doses of 0.15–50.0 µg/kg. When a tail is irritated, L-lysine was found to enhance pain sensitivity and affective defense after both intraperitoneal and intracerebroventricular administration. In the case of unavoidable painful irritation of a pair of rats with both types of L-lysine administration, there was no direct correlation of the severity of pain with defensive reactions and outbursts of aggression. This indicates a more complex integration of the activity of brain structures in this situation of animal interaction, which was confirmed by the results of the direct amino acid action on the periventricular brain structures. Our findings show that L-lysine influences the selective brain activity in dependence on the biological significance of pain-induced behavior