13 research outputs found
ΠΠΎΡΠ΄Π΅ΠΉ ΠΠ°ΠΊΡΠΈΠΌΠΎΠ²ΠΈΡ ΠΠΎΡΠΈΡΠΎΠ² (ΠΊ 140-Π»Π΅ΡΠΈΡ ΡΠΎ Π΄Π½Ρ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ)
Submitted biography of professor Gordey Maksimovich Iosifov β founder of the national lymphology, head of the chair of normal anatomy of the Imperial Tomsk University has been presented.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π° Π½Π°ΡΡΠ½Π°Ρ Π±ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ ΠΎΡΠ½ΠΎΠ²ΠΎΠΏΠΎΠ»ΠΎΠΆΠ½ΠΈΠΊΠ° ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π·Π°Π²Π΅Π΄ΡΡΡΠ΅Π³ΠΎ ΠΊΠ°ΡΠ΅Π΄ΡΠΎΠΉ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ Π°Π½Π°ΡΠΎΠΌΠΈΠΈ ΠΠΌΠΏΠ΅ΡΠ°ΡΠΎΡΡΠΊΠΎΠ³ΠΎ Π’ΠΎΠΌΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° ΠΏΡΠΎΡΠ΅ΡΡΠΎΡΠ° Π.Π. ΠΠΎΡΠΈΡΠΎΠ²Π°
ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌΡ ΡΠ΅Π»Π° ΠΌΠ°ΡΠΊΠΈ
Analysis of clinical-anamnestic and morphological features of a cellular and simple leiomyoma of a uterus is leading. Features of a leiomyoma of a uterus with cellular texture of the site are determined: young age, monthly since 15 years ((20,0 Β± 4,6)%), often use ΠΠΠ ((38,7 Β± 5,6)%), an infrequent combination to infringement of genesial function. Analysis of Π‘D31, Ki-67, and Ag-NORproteins expression in the greater and smaller tumour which have been taken away from one macropreparation was carried out.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΈ ΠΏΡΠΎΡΡΠΎΠΉ Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌΡ ΠΌΠ°ΡΠΊΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π»Π΅ΠΉΠΎΠΌΠΈΠΎΠΌΡ ΠΌΠ°ΡΠΊΠΈ Ρ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ·Π»Π°: ΠΏΠΎΠ·Π΄Π½Π΅Π΅ Π½Π°ΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΌΠ΅Π½Π°ΡΡ
Π΅ ((20,0 Β± 4,6)%), ΡΠ°ΡΡΠΎΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π½ΡΡΡΠΈΠΌΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΠΎΠ½ΡΡΠ°ΡΠ΅ΠΏΡΠΈΠ²ΠΎΠ² ((38,7 Β± 5,6)%), ΡΠ΅Π΄ΠΊΠΎΠ΅ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π‘D31, Ki-67 ΠΈ Π°ΡΠ³ΠΈΡΠΎΡΠΈΠ»ΡΠ½ΡΡ
ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΡΠ΄ΡΡΡΠΊΠΎΠΎΠ±ΡΠ°Π·ΡΡΡΠΈΡ
ΡΠ°ΠΉΠΎΠ½ΠΎΠ² Π±Π΅Π»ΠΊΠΎΠ² Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΠΈ ΠΌΠ΅Π½ΡΡΠ΅ΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, Π·Π°Π±ΡΠ°Π½Π½ΡΡ
ΠΈΠ· ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠ°ΠΊΡΠΎΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°
Gordey Maksimovich Iosifov (to the 140 anniversary)
Submitted biography of professor Gordey Maksimovich Iosifov β founder of the national lymphology, head of the chair of normal anatomy of the Imperial Tomsk University has been presented
A study of the level of circulating cytokines in patients with atopic dermatitis
Goal of the study. To study the role of pro-inflammatory and anti-inflammatory cytokines for the course of atopic dermatitis (AD). Materials and methods. The study involved 72 patients aged 25-55 suffering from atopic dermatitis for 2-30 years and with at least two relapses a year. The AD patients were assigned to the following groups depending on the SCORAD (iSc) index: Group 1: light form (iSc 50 points). The control group comprised 23 practically healthy subjects aged 25-35. The level of cytokines (IL-1 Ξ², -4, -6, -8, -10, -12, -13, TNF-Ξ± and IFN-Ξ³) in blood serum was determined based on the immune-enzyme assay method. Results. A trend to the increased production of anti-inflammatory cytokines (IL-4, -6, -10, -13) at the exacerbation stage and increased synthesis of pro-inflammatory ones (IFN-Ξ³, TNF-Ξ± and IL-12) at the remission stage was observed in patients with atopic dermatitis, which confirms the dysregulation of reciprocal relationships between Th1 and Th2 lymphocyte subpopulations during the disease
Role of disorders related to idiotypic and anti-idiotypic interactions in slowing down the achievement of negative serologic reactions in patients with early onset forms of syphilis after specific therapy
Goal. To study the humoral immunity state in patients with the slowed down achievement of negative serologic reactions after the treatment of early onset forms of syphilis by means of examining the blood serum level of idiotypic and anti-idiotypic antibodies to cardiolipin and p17 Treponema Pallidum antigenic protein. Materials and methods. The study involved 324 patients (39.5% male and 60.5% female) with the slowed down achievement of negative serologic reactions. Primary (idiotypic) antibodies to cardiolipin and p17 protein were obtained using immunochromatographic assays with the help of the Bio Logik LP system. Purified antibodies were concentrated using the ultrafiltration technique with the aid of the XM-100Π membrane. To obtain the rabbit antiserum to p17 Treponema Pallidum protein, chinchilla rabbits were immunized using the commercial recombinant p17 protein. To determine anti-cardiolipin idiotypic antibodies in the blood serum, the ELISa method optimized for detecting anti-cardiolipin antibodies was applied. To determine anti-cardiolipin anti-idiotypic antibodies as well as idiotypic and anti-idiotypic antibodies to p17 Treponema Pallidum protein, the standard ELISA method was applied. The following antigens were used to process the pads: F(ab)2 fragments of anti-cardiolipin antibodies (5 ΞΌg/mL), recombinant Ρ17 T. pallidum protein (5 ΞΌg/mL) and F(ab)2 fragments of antibodies to Ρ17 T. pallidum protein (10 ΞΌg/mL). The level of antibodies was assessed based on the absorbancy and expressed in conventional activity units using the K coefficient being the absorbancy of the serum under examination to the mean absorbancy of control serums ratio. The K value exceeding 1.5 conventional units indicated the increased level of antibodies. Results. Patients with the slowed down achievement of negative serologic reactions demonstrated a selective increase in the level of anti-idiotypic antibodies (AIAB) relative to T. pallidum antigens, cardiolipin and p17 protein, vs. first-order antibodies, which points at abnormal mutual regulation between idiotypic antibodies (IAB) and AIAB; the discovered phenomenon lays the immunochemical basis for the formation of a self-sustaining βvicious circleβ contributing to the induction of high levels of antibodies to treponema antigens even when the pathogen was destroyed
Nikolai Mikhailovich Maliyev (to the 170 anniversary)
Provided scientific biography of the founder of the Museum of human anatomy and the first Professor of normal Anatomy of the ImperialTomskUniversity N. Maliyev
Clinical and morphological features uterin corpus cellular leiomyoma
Analysis of clinical-anamnestic and morphological features of a cellular and simple leiomyoma of a uterus is leading. Features of a leiomyoma of a uterus with cellular texture of the site are determined: young age, monthly since 15 years ((20,0 Β± 4,6)%), often use ΠΠΠ ((38,7 Β± 5,6)%), an infrequent combination to infringement of genesial function. Analysis of Π‘D31, Ki-67, and Ag-NORproteins expression in the greater and smaller tumour which have been taken away from one macropreparation was carried out