16 research outputs found
Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of MultiâSubstituted Î 2
Advances in 1,3,5-triazepines chemistry
This review describes a literature survey of 1,3,5-triazepines. The investigated heterocycles were the monocyclic and fused 1,3,5-triazepines. The different sections of the paper cover: theoretical methods, spectroscopy aspects, thermodynamic aspects, synthesis and reactions of the monocyclic and fused heterocycles incorporated into the 1,3,5-triazepine moiety. The biological evaluation of the target compounds are also described as well as their synthetic applications. The reaction mechanisms are discussed. © 2016 The Royal Society of Chemistry
Novel in vitro assays for the characterization of EMT in tumourigenesis
Background: Two novel assays quantifying Epithelial to Mesenchymal Transition (EMT) were compared to traditional motility and migration assays. TGF-ÎČ1 treatment of AY-27 rat bladder cancer cells acted as a model of EMT in tumourigenesis