3 research outputs found
Evaluation of radionuclide testicular scan
μνκ³Ό/μμ¬[νκΈ]
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μ΄μ κ°μ΄ λ°©μ¬μ±λμμμλ₯Ό μ΄μ©ν κ³ νμ£Όμ¬λ λΉκ΅μ κ°λ¨νκ³ νμκ° λ°λ gonadal doseμ μμ΄ λ§μ§ μμΌλ©΄μλ κ°μ’
μ§νμ λ°λ₯Έ μ견μ λΉκ΅μ νΉμ§μ μ΄μ΄μ μ¬λ¬κ°μ§ μλλ΄ μ§νμ κ°λ³μ§λ¨μ ν° λμμ μ€ μ μμλ€. νΉν κΈμ± μλ μ¦μμ κ°μ§ νμμμ μ§λ¨κ³Ό μΉλ£ λ°©λ²μ κ²°μ μ μν μκΈ κ²μ¬λ‘μ¨ μ μ©νμλ€.
Evaluation of Radionuclide Testicular scan
Nam Yoon Huh
Department of Medical Science The Graduate School, Yonsei University
(Directed by professor Chang Yun Park, M.D.)
There has been no adequate diagnostic method for the diagnosis of intrascrotal
lesions until recent days. But after the development of radionuclide testicular
scan, early and relatively accurate diagnosis of the testicular lesions are
possible.
So the author analyzed the 32 cases of patients who were examined by testicular
scan and confirmed by follow up study or operation, and the results are as fellows;
1. These 32 cases consists of 13 cases of epididymitis, 7 cases of testicular
torsion, 4 of cryptorchism, 2 of testicular tumor and etc. The over all diagnostic
accuracy is about 69%.
2. In eplididymitis, the diagnostic accuracy is 85% (ll/13) and the findings of
scan are increased perfusion in radionuclide angiogram and hot activity noted
mainly in peripheral portion of the testicle in static image.
3. In cases of testicular torsion, dignostic accuracy is 86%(6/7).
Acute torsion shows normal perfusion in angiogram and round cold area in static
image. But in missed torsion, perfusion is increased and round cold area with
surrounding hyperemia is noted in static image.
Radionuclide testicular scan seems to be noninvasive, inexpensive easily
available and simple to perform with low gonadal radiation dose.
So it can be very useful as the first study in patients with acute testicular
symptoms.
[μλ¬Έ]
There has been no adequate diagnostic method for the diagnosis of intrascrotal lesions until recent days. But after the development of radionuclide testicular scan, early and relatively accurate diagnosis of the testicular lesions are possible.
So the author analyzed the 32 cases of patients who were examined by testicular scan and confirmed by follow up study or operation, and the results are as fellows;
1. These 32 cases consists of 13 cases of epididymitis, 7 cases of testicular torsion, 4 of cryptorchism, 2 of testicular tumor and etc. The over all diagnostic accuracy is about 69%.
2. In eplididymitis, the diagnostic accuracy is 85% (ll/13) and the findings of scan are increased perfusion in radionuclide angiogram and hot activity noted mainly in peripheral portion of the testicle in static image.
3. In cases of testicular torsion, dignostic accuracy is 86%(6/7).
Acute torsion shows normal perfusion in angiogram and round cold area in static image. But in missed torsion, perfusion is increased and round cold area with surrounding hyperemia is noted in static image.
Radionuclide testicular scan seems to be noninvasive, inexpensive easily available and simple to perform with low gonadal radiation dose.
So it can be very useful as the first study in patients with acute testicular symptoms.restrictio
(A) morphological study of the radioprotective effect of vasopressin on radiation induced nephritis in mice.
μνκ³Ό/λ°μ¬[νκΈ]
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μμΈν¬μ μ μμΈν¬μ λ°©μ¬μ κ°μμ±μ μ°¨μ΄λ₯Ό μ¦κ°μν€κΈ° μνμ¬ λ°©μ¬μ 보νΈλ¬Όμ§μ΄ λ§μ΄ κ°λ°λμ΄ μκ³ (Dowdy λ±, 1950; Gray λ±, 1952; Van den Brenk λ±, 1966) μΌμμ μ μ°μμ¦μ μ΄λνμ¬ μ‘°μ§μ λ°©μ¬μ κ°μμ±μ μ νμν€λ νκ΄μμΆμ λ€μ΄ μ΄μ ν¬ν¨λλ€. Vasopressinμ μ΄λ¬ν λ°©μ¬μ 보νΈλ¬Όμ§μ νλλ‘μ 볡κ°λ΄ μ£Όμ¬ν λ°©μ¬μ μ‘°μ¬μ, μμ₯κ΄μ λν 보νΈμμ©μ μ΄λ―Έ μλ €μ Έ μμΌλ(μ΄ λ±, 1981) μ΄λμ λκΈ°κ°μ κ²½κ³Ό ν μ μ₯μ λνλλ λ°©μ¬μ μ μ₯μΌ (radiation nephritis)μ μ΄λ ν μν₯μλ―ΈμΉλμ§μ κ΄ν μ°κ΅¬λ μμ§κΉμ§ μνλ λ° μλ€.
λ³Έ μ€νμ λ§μ°μ€μ 볡κ°μ μ리μμΌμλ₯Ό μ£Όμ¬ν ν λ°©μ¬μ μ μ‘°μ¬νμ¬ λνλλ μ μ₯μ λ³λ³κ³Ό vasopressinμ μ μ²μΉ ν λ°©μ¬μ μ μ‘°μ¬νμμ λ λνλλ μ μ₯μ λ³λ³μ κ΄ννλ―Έκ²½κ³Ό μ μνλ―Έκ²½μ μ΄μ©νμ¬ νννμ κ΄μ°°μ νκ³ μ‘°μ§νμ λ°©λ²μ ν΅ν΄ μ μ₯ λ΄μ ν¬ν¨λλ ν¨μλ³νμ κ΄μ°°, κ·Έλ¦¬κ³ νμ‘μ μννμ κ²μ¬λ₯Ό ν΅ν΄ μ μ₯κΈ°λ₯μ λ³ν λ±μ 보기 μν κ²μ΄λ€.
μ²΄μ€ 20gm λ΄μΈμ λ§μ°μ€(Swiss 1015) 128λ§λ¦¬λ₯Ό μ¬μ©νμ¬ μ€νκ΅°μ λ°©μ¬μ μ‘°μ¬ μ§μ vasopressin 4 units (Postacton, Ferring)λ₯Ό μ리μμΌμμ νΌν©νμ¬ 1 mlλ₯Ό λ³΅κ° λ΄μμ£Όμ¬νμκ³ λμ‘°κ΅°μ μ리μμΌμλ₯Ό 1 ml μ£Όμ¬νμλ€. λ°©μ¬μ μ‘°μ¬ ν 1, 3, 7, 15, 30, 6
0, 90μΌμ 체μ€μ κ³μΈ‘νκ³ ν¬μμμΌ νμ‘μ μ±μ·¨νκ³ μ μ₯μ μ μΆνμ¬ κ΄ννλ―Έκ²½ κ²μ, alkaline phosphatase νμ±λμ μ‘°μ§ννμ κ²μ¬, μ μνλ―Έκ²½ κ²μμ μννμκ³ νμ‘λ΄μ urea nitrogenλλλ₯Ό μΈ‘μ νμ¬ λ€μκ³Ό κ°μ κ²°κ³Όλ₯Ό μ»μλ€.
1. λ°©μ¬μ μ‘°μ¬λ‘ μΈν μ λ°μ λ³λ³μ΄, μ‘°μ¬ν 15μΌ κ²½λΆν° λμ‘°κ΅°μ΄ μ€νκ΅°μ λΉνμ¬μ¬νμμΌλ©°, μ μνλ―Έκ²½ μ견μΌλ‘ λνλλ κ·Ήμ¬ν μΈν¬μ νκ΄΄μμμ μ‘°μ¬μ§νλΆν° λνλκΈ° μμνμ¬ λμ‘°κ΅°μμλ 60μΌ, μ€νκ΅°μμλ 15μΌμ μ¬μλλ μ견μ 보μλ€.
2. Alkaline phosphatase νμ±λλ λ°©μ¬μ μ‘°μ¬ ν μκ΅° λͺ¨λμμ κ°μνλ€κ° λμ‘°κ΅°μμλ 60μΌμ, μ€νκ΅°μμλ 15μΌμ μ μμΌλ‘ ν볡λλ μμμ 보μλ€.
3. νμ€ λ¨μμ§μμ λλλ λ°©μ¬μ μ‘°μ¬ ν 7μΌκΉμ§ μκ΅° λͺ¨λμμ κ°μνλ€κ° μ€νκ΅°μμ 15μΌ μ΄νλΆν° μ¦κ°νλ μΆμΈλ₯Ό λ³΄μ¬ μ£Όμλ€.
4. λ°©μ¬μ μ‘°μ¬ ν λμ‘°κ΅°κ³Ό μ€νκ΅° κ°μ μμ‘΄μ¨μ μ°¨μ΄λ λ³Ό μ μμλ€.
5. λ°©μ¬μ μ‘°μ¬ ν μκ΅° λͺ¨λ 체μ€μ κ°μλ₯Ό 보μ΄λ€κ° 7μΌ μ΄νλΆν° μ¦κ°νκΈ° μμνμκ³ μ€νκ΅°μμ 30μΌ μ΄νμ 체μ€κ°μ νμμ΄ λ€μ λνλ¬λ€.
μ΄μμ μ견μ μ’
ν©νμ¬ λ³Ό λ vasopressinμ μ²μΉ ν ν λ°©μ¬μ μ μ‘°μ¬νλ©΄ λμ‘°κ΅°μλΉν΄ μ‘°μ§μ μμμ κ°λ³κ² νκ³ νκ΄΄λ μ‘°μ§μ μ¬μμκΈ°λ₯Ό μλΉκ²¨ μ£Όλ κ²μΌλ‘ 보μ vasopressinμ΄ λ°©μ¬μ μ λνμ¬ λ³΄νΈν¨κ³Όκ° μλ€κ³ μ¬λ£λλ€.
[μλ¬Έ]
Vasopressin is known to be a radioprotective substance due to its vasoconstriction action which results in temporary hypoxia. Total of 128 mice (Swiss 1015) were used as experimental animal. Following intraperitoneal injection of vasopressin, radiation (1000 rads) was administered to mice and biochemical and morphological studies were performed on their kidneys.
Results obtained were as follows :
1. Morphologically, differences between control and experimental groups appeared 15 days after irradiation. The experimental group exhibited less cellular damage than the control group. Electron microscopic findings showed that there was severe cellular destruction immediately after irradiation, and that cellular regeneration had begun 15 days after irradiation in the experimental group and 60 days after irradiation in the control group.
2. Both groups showed a decrease in alkaline phosphatase activity following irradiation. A return to normal enzyme levels began 15 days after irradiation in the experimental group and 60 days after irradiation in the control group.
3. The concentration of blood urea nitrogen(BUN) decreased in both groups for 7 drys following irradiation. The experimental group began to demonstate an increase in BUN 15 days after irradiation.
4. There was no difference in survival rate between control and experimental groups.
5. Both groups exhibited a weight loss immediately after irradiation and a weight gain which began 7 days following irradiation.
Summarizing the above data, vasopressin seems to have a radioprotective effect on the kidney. Radiation after vasopressin injection causes less damage and shortens the amount of time needed for the regeneration of renal tissue.restrictio