23 research outputs found
(The) analysis of risk factors influencing lymph node metastasis in invasive carcinoma of the cervix
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The Analysis of Risk Factors Influencing Lymph Node Metastasis in Invasive
Carcinoma of the Cervix
HYUNG MIN CHOI
Department of Obsterics and Gynecology The Graduate School,
Yonsei University
(Directed by Professor Tchan Kyu Park M.D.)
It is well known that in patients with invasive carcinoma of the cervix high risk
factors such as lymph node metastasis are closely related t? treatment fai lurers
caused by residual cancer or recurrent cancer after primary treatment. To prevent
this, additional supportive measures are belong conducted with the primary
treatment modality. One hundred and seventy nine patients who underwent
pretreatment 1aparotomy for invasive cervix cancer, and who were confirmed as
having lymph node metastasis, were studied for high risk factors at the Yonsei
University College of Medicine, Severance Hospital, Department of Obstetrics and
Gynecology from January 1976 to May 1990.
The results showed that in 13.7%(25 cases) of the cases, 1ymph node metastasis
was present, and the patients in their 5th decade comprised the most common age
group. There was no relationship between age and lymph node metastasis rate .The
lymph node metastasis rate was significantly higher in patients with cancer that
was larger in leison size, of cell types other than large cell non-keratinizing
such as small cell type, with deeper invasion, with lymphovascular invasion, and
with lymphocyte depletion in lymph node morphology. Also mild infiltration with
lymphoplasmacyte was correlated with the higherlymph node metastasis rate, but was
not stastistically significant.
[μλ¬Έ]
It is well known that in patients with invasive carcinoma of the cervix high risk factors such as lymph node metastasis are closely related t? treatment fai lurers caused by residual cancer or recurrent cancer after primary treatment. To prevent this, additional supportive measures are belong conducted with the primary treatment modality. One hundred and seventy nine patients who underwent pretreatment 1aparotomy for invasive cervix cancer, and who were confirmed as having lymph node metastasis, were studied for high risk factors at the Yonsei University College of Medicine, Severance Hospital, Department of Obstetrics and
Gynecology from January 1976 to May 1990.
The results showed that in 13.7%(25 cases) of the cases, 1ymph node metastasis was present, and the patients in their 5th decade comprised the most common age group. There was no relationship between age and lymph node metastasis rate .The lymph node metastasis rate was significantly higher in patients with cancer that was larger in leison size, of cell types other than large cell non-keratinizing such as small cell type, with deeper invasion, with lymphovascular invasion, and with lymphocyte depletion in lymph node morphology. Also mild infiltration with
lymphoplasmacyte was correlated with the higherlymph node metastasis rate, but was not stastistically significant.restrictio
DRF based Object Detection and Classification with a Multi-scale Texton Histogram
Thesis(masters) --μμΈλνκ΅ λνμ :μ κΈ°. μ»΄ν¨ν°κ³΅νλΆ, 2009.2.Maste
Vasomotor activities on the umbilical arteries in pregnancy-induced hypertension
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Pregnancy-induced hypertension has been town as a hypertensive disorder of the 2nd and 3rd trimester of pregnancy, and it also accounts for a major proportion of maternal mortality. Intrauterine fetal growth restriction and perinatal mortality
due to poor fetoplacental circulation are also known as major complications of pregnancy-induced hyper-tension. Several clinical and biochemical findings suggest that the disturbance of normal endothelial function may be a primary cause in the pathogenesis of pregnancy-induced hypertension. However, there has been no specific direct report about endothelial dysfunction in the umbilical artery of pregnancy-induced hypertension patients, and it is still uncertain whether or not the function of the smooth muscle cell of the umbilical artery is affected. In the present study, we directly examined the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from pregnancy-induced hypertension patients using a conventional tension measurement and bioassay experiment.
Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in pregnancy-induced hyper-tension(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from pregnancy-induced hypertension (p<0.01). To test the change of endothelial cell function in pregnancy-induced hypertension without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor
and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement(p<0.01). Relaxation responses to 8-bromo-cGMP inhuman umbilical artery rings were also significantly decreased in pregnancy-induced
hypertension(p<0.01).
From the above results, it can be concluded that increased vascular resistance in pregnancy-induced hypertension is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction.restrictio