22 research outputs found
์ด์์ ์ ๋์ ํผํฉ ์ฆ๋๋ฅผ ์ํ ์ต์ ๊ณต๋ ์ค๊ณ์ ์คํ์ ์ฐ๊ตฌ
ํ์๋
ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :๊ธฐ๊ณํญ๊ณต๊ณตํ๋ถ,2004.Maste
Postprocessing with neural networks for music signals coded by speech codec
ํ์๋
ผ๋ฌธ(์์ฌ) --์์ธ๋ํ๊ต ๋ํ์ :์ ๊ธฐ. ์ปดํจํฐ๊ณตํ๋ถ,2007.Maste
Intrathecal synthesis of immunoglobulin G (IgG) and anti-Tbc humoral immune response in the tuberculous meningitis
์ํ๊ณผ/์์ฌ[ํ๊ธ]
์ต๊ทผ ๋ฉด์ญํ์ ๋ฐ๋ฌ๋ก ์ ๊ฒฝ๊ณ๋ฅผ ์นจ๋ฒํ๋ ์ผ์ฆ ์งํ์์ ์ฒด์ก์ฑ ๋ฉด์ญ ๋ฐ์์ด ๊ตญ์์ ์ผ๋ก ์ผ์ด๋๊ณ ์์์ด ๋๋ฆฌ ์๋ ค์ ธ ์์ผ๋ ๊ฒฐํต์ฑ ๋๋ง์ผ์ ์์ด์๋ ์์ง ์ฒด๊ณ์ ์ฐ๊ตฌ๊ฐ ์ด๋ฃจ์ด ์ง์ง ์๊ณ ์๋ค. ๋ํ ๊ฒฐํต์ฑ ๋๋ง์ผ์ ๋ฉด์ญํ์ ์ง๋จ๋ฐฉ๋ฒ์ผ๋ก purified protein
derivative(PPD)๋ฐ lipoarabinomannan(LAM)ํญ์์ ๋ํ IgG ํญ์ฒด๊ฐ์ ์์์ ๊ฐ์น๋ ์์ง ๋ช
ํํ์ง ์๋ค. ๋ณธ ์ฐ๊ตฌ๋ ๊ฒฐํต์ฑ ๋๋ง์ผ์์ ์ฒด์ก์ฑ ๋ฉด์ญ๋ฐ์์ ์ํ IgG ํ์ฑ์ด ์ ๊ฒฝ๊ณ๋ด์์ ์ด๋ฃจ์ด ์ง๋ฉฐ, PPD ๋ฐ LAM ํญ์์ ๋ํ IgG ํญ์ฒด๊ฐ์ ์ธก์ ์ด ์กฐ๊ธฐ ์ง๋จ์ ๋์์ด
๋๋์ง๋ฅผ ๊ท๋ช
ํ๊ณ ์ ๊ฒฐํต์ฑ ๋๋ง์ผ ํ์์ ํ๊ฒฐํต๋ง์ ๊ฐ๊ณ ์๋ ํ์๋ฅผ ํ์๊ตฐ๊ณผ ๋์กฐ๊ตฐ์ผ๋ก ์ ์ ํ์ฌ ๊ทธ๋ค์์ IgG synthetic rate์ PPD ๋ฐ LAM ํญ์์ ๋ํ IgG ํญ์ฒด๊ฐ๋ฅผ ์ธก์ ํ์ฌ ๋ค์๊ณผ ๊ฐ์ ๊ฒฐ๊ณผ๋ฅผ ์ป์๋ค.
1. IgG synthetic rate๋ ๊ฒฐํต์ฑ ๋๋ง์ผ ํ์๊ตฐ์์ 56.4 ยฑ 18.9 mg/day๋ก ๋์กฐ๊ตฐ์ 7.5 ยฑ 4.3 mg/day์ ๋นํด ํต๊ณํ์ ์ผ๋ก ์ ์์๊ฒ (p<0.001) ์ฆ๊ฐ๋์ด ์ค์ถ์ ๊ฒฝ๊ณ๋ด ์ฒด์ก์ฑ ๋ฉด์ญ ๋ฐ์์ ์ํ ํญ์ฒด ํ์ฑ์ด ์์์ ์ ์ ์์๋ค.
2. ๋์กฐ๊ตฐ์์ ํ์ฒญ๋ด ํญ๊ฒฐํต์ฑ ๋ฉด์ญ ๋ฐ์์ด ์์ฑ์ผ ๊ฒฝ์ฐ ๊ทธ ์ ๋์ ๋ฐ๋ผ์ ์ ์์ ์ผ๋ก ๋ชจ์ธํ๊ด์ ํตํ์ฌ ๋์ฒ์์ก๋ด๋ก ๋จ์ํ์ฐ๋์ด PPD๋ฐ LAMํญ์์ ๋ํ ํญ์ฒด๊ฐ๊ฐ ๋์ฒ์์ก๋ด์์๋ ์์ฑ์ ๋ณด์ผ ์ ์์๋ค.
3. ๊ฒฐํต์ฑ ๋๋ง์ผ์ ์กฐ๊ธฐ ์ง๋จ์ ์ํ ๋ฉด์ญํ์ ๊ฒ์ฌ์ธ PPD๋ฐ LAMํญ์์ ๋ํ ๋ฉด์ญ๊ธ๋ก๋ถ๋ฆฐ์ ํญ์ฒด๊ฐ ์ธก์ ์ ์์์ ๊ฐ์น๋ IgG synthetic rate์ ์ํธ ๋ณด์์ ์๋ฏธ๋ฅผ ๊ฐ๊ณ ์์๋ค.
๋ฐ๋ผ์ ๊ฒฐํต์ฑ ๋๋ง์ผ์ ์กฐ๊ธฐ ์ง๋จ์ ์ํ ๋ฉด์ญํ์ ๊ฒ์ฌ๋ฐฉ๋ฒ์ธ PPD ๋ฐ LAMํญ์์ ๋ํ IgG ํญ์ฒด๊ฐ์ ์์์ ๊ฐ์น๋ IgG synthetic rate๊ฐ ์์ฑ์ธ ๊ฒฝ์ฐ์๋ง ๊ทธ ์๋ฏธ๋ฅผ ๊ฐ์ง ์ ์์๋ค.
Intrathecal synthesis of immunoglobulin G (IgG) and anti-Tbc humoral immune
response in the tuberculous meningitis
Tae-Young Cho
Department of Medical Science, The graduate School, Yonsei University
(Directed by Professor Byung In Lee )
Immunological diagnosis of tuberculous meningitis requires the presence of de nove
synthesis of immunoglobulin in central nervous system, which has not been
systematically investigated yet. Previously, the diagnostic value of IgG reactivity
to lipoarabinomanan(LAM) and PPD antigens in cerebrospinal fluid was presented.
However, we could net exclude the possibility of passive transfer of IgG from the
systemic circulation to the cerebrospinal fluid through the blood brain barrier. We
studied the de nove synthesis of IgG and the diagnostic value of IgG antibody titer
to PPD and LAM antigens.
The following results were obtained.
1. Intrathecally, de novo synthesis of IgG was existed in tuberculous meningitis,
because IgG synthetic rate were higher than control group siglificantlly.
2. Seropositivity to PPD and LAM antigens in cerebrospinal fluid were possible in
abnormally high titer Of IgG in peripheral blood although the patients were in
control group.
3. To prove that cerebrospinal IgG reactive to LAM and PPD antigens is diagnostic
for tuberculous meningitis, demonstration of de novo synthesis of IgG in central
nervous system is the essential prerequisite.
[์๋ฌธ]
Immunological diagnosis of tuberculous meningitis requires the presence of de nove synthesis of immunoglobulin in central nervous system, which has not been systematically investigated yet. Previously, the diagnostic value of IgG reactivity
to lipoarabinomanan(LAM) and PPD antigens in cerebrospinal fluid was presented.
However, we could net exclude the possibility of passive transfer of IgG from the systemic circulation to the cerebrospinal fluid through the blood brain barrier. We studied the de nove synthesis of IgG and the diagnostic value of IgG antibody titer
to PPD and LAM antigens.
The following results were obtained.
1. Intrathecally, de novo synthesis of IgG was existed in tuberculous meningitis, because IgG synthetic rate were higher than control group siglificantlly.
2. Seropositivity to PPD and LAM antigens in cerebrospinal fluid were possible in abnormally high titer Of IgG in peripheral blood although the patients were in control group.
3. To prove that cerebrospinal IgG reactive to LAM and PPD antigens is diagnostic for tuberculous meningitis, demonstration of de novo synthesis of IgG in central nervous system is the essential prerequisite.restrictio