유통업 여성 근로자의 건강 문제와 건강 행위에 관한 연구

학위논문(석사)--서울대학교 대학원 :간호학과 간호학전공,1999.Maste

(A)Structural model development on work-related musculoskeletal disorders of women workers

학위논문(박사)--서울대학교 대학원 :간호학과 간호학 전공,2004.Docto

NIE 프로그램이 과학과 관련된 태도와 학업 성취도에 미치는 영향

학위논문(석사)--서울대학교 대학원 :과학교육과 지구과학전공,1998.Maste

Analysis on the types of e-learning process in nursing students

학위논문(박사)--서울대학교 대학원 :간호학과,2007.Docto

Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer

To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted in vitro and in vivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic-co-glycolic acid)–Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10 min, which caused an increase in temperature to 45 °C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemo-photothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors.ope

Capacitance-based assay for real-time monitoring of endocytosis and cell viability.

Label-free cell-based assays have emerged as a promising means for high-throughput screening. Most label-free sensors are based on impedance measurements that reflect the passive electrical properties of cells. Here we introduce a capacitance-based assay that measures the dielectric constant (capacitance) of biological cells, and demonstrate the feasibility of analyzing endocytosis and screening chemotherapeutic agents with this assay. Endocytosis induces a change in the zeta potential, leading to a change in the dielectric constant which enables real-time endocytosis monitoring using the capacitance sensor. Additionally, since the dielectric constant is proportional to cell radius and cell volume, cell viability can be estimated from the change in capacitance. Therefore, the capacitance sensor array can also be used for cytotoxicity testing for large-scale chemotherapeutic screening.ope