122 research outputs found
์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ ๋ฐ ๊ตฌ์ฑ ์์๋ค ๊ฐ์ ์ฐ๊ด์ฑ ๋ถ์
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ผ๋ฌธ (์์ฌ)-- ์์ธ๋ํ๊ต ๋ณด๊ฑด๋ํ์ : ๋ณด๊ฑดํ๊ณผ(๋ณด๊ฑดํ์ ๊ณต), 2013. 2. ์ฑ์ฃผํ.์ฐ๊ตฌ๋ฐฐ๊ฒฝ: ์ฐ๋ น์ด ์ฆ๊ฐํจ์ ๋ฐ๋ผ ๊ทผ์ก๋์ด ๊ฐ์ํ๋ ๊ทผ์ก๊ฐ์์ฆ (sarcopenia)์ ํนํ ๋
ธ์ธ์์ ์ธ์๋ฆฐ ์ ํญ์ฑ, ๋น๋จ, ๋์ฌ์ฆํ๊ตฐ๊ณผ ๊ฐ์ ์ฌํ๊ด๊ณ ์งํ์ ์ํ์ธ์์ ๊ด๋ จ์ด ์๋ ๊ฒ์ผ๋ก ์๋ ค์ ธ ์๋ค. ๋ฏธ๊ตญ์ ์ฑ์ธ์ ๋์์ผ๋ก ์ํํ ํ ์ฐ๊ตฌ์์๋ ๊ทผ์ก๊ฐ์์ฆ ๋ฒ์ฃผ๊น์ง ํฌํจ๋์ง ์๋๋ผ๋, ๋ฎ์ ์๋์ ๊ทผ์ก๋ ๋ํ ์ธ์๋ฆฐ ์ ํญ์ฑ ๋ฐ ๋น๋จ์ ๋จ๊ณ (prediabetes)์ ์ฐ๊ด์ฑ์ด ์์์ ๋ณด๊ณ ํ ๋ฐ ์๋ค.
๋ชฉ์ : ์ด๋ฒ ์ฐ๊ตฌ๋ 19์ธ ์ด์์ ํ๊ตญ์ธ์ ๋์์ผ๋ก ์๋์ ๊ทผ์ก๋ (appendicular skeletal muscle mass / weight (%))๊ณผ ๋์ฌ์ฆํ๊ตฐ ๋ฐ ๊ทธ ๊ตฌ์ฑ ์์์ธ ์์ถ๊ธฐ ํ์, ์ด์๊ธฐ ํ์, ๊ณต๋ณตํ๋น, ์ค์ฑ์ง๋ฐฉ, ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค ๋ฐ ์ธ์๋ฆฐ ์ ํญ์ฑ ์งํ์ ๊ฐ์ ์ฌํ๊ด๊ณ ์งํ ์ํ์ธ์๋ค ์ฌ์ด์ ์ฐ๊ด์ฑ์ ์์๋ณด๊ณ ์ ํ์๋ค.
๋ฐฉ๋ฒ: 2008 ~ 2010๋
์ ์ํ๋ ์ 4๊ธฐ ~ ์ 5๊ธฐ 1์ฐจ ๊ตญ๋ฏผ๊ฑด๊ฐ์์์กฐ์ฌ์ ์ฐธ์ฌํ๋ 12,444๋ช
์ ์๋ฃ๋ฅผ ์ด์ฉํ์ฌ ๋จ๋ฉด ์ฐ๊ตฌ๋ฅผ ์ํํ์๋ค. ๋ณตํฉํ๋ณธ ์๋ฃ์ ๋ํ ๋ค์ค๋ก์ง์คํฑ ํ๊ท๋ถ์์ ์ด์ฉํ์ฌ ์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ ๋ฐ ๊ทธ ๊ตฌ์ฑ ์์๋ค(ํ์ ์์น, ๊ณต๋ณตํ๋น์ฅ์ , ๊ณ ์ค์ฑ์ง๋ฐฉํ์ฆ, ๋ฎ์ ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค ๋ฐ ๋ณต๋ถ๋น๋ง)๊ณผ์ ์ฐ๊ด์ฑ์ ๋ถ์ํ์๋ค. ๋ํ, ๋ณตํฉํ๋ณธ ์๋ฃ์ ๋ํ ๋ค์ค์ ํํ๊ท๋ถ์์ ์ด์ฉํ์ฌ ๊ต๋๋ณ์๋ฅผ ํต์ ํ์ ๋ ์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ์ ์์๋ค(ํ์, ๊ณต๋ณตํ๋น, ์ค์ฑ์ง๋ฐฉ, ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค) ๋ฐ ์ธ์๋ฆฐ ์ ํญ์ฑ ์งํ ์ฌ์ด์ ์ฐ๊ด์ฑ์ ์กฐ์ฌํ์๋ค. ๋ถ์์ ๋จ๋
๊ตฐ์ผ๋ก ์ธตํํ์ฌ ์ํํ์์ผ๋ฉฐ, ๋จ์ฑ์ 60์ธ๋ฅผ ๊ธฐ์ค์ผ๋ก, ์ฌ์ฑ์ ํ๊ฒฝ ์ ํ๋ฅผ ๊ธฐ์ค์ผ๋ก ๋๋ ๊ทธ๋ฃน์์๋ ์ถ๊ฐ์ ์ผ๋ก ๋ถ์์ ์ํํ์๋ค.
๊ฒฐ๊ณผ: ๊ต๋๋ณ์์ ์ํฅ์ ๋ณด์ ํ ๋ค, ์ ์ฒด ๋จ์ฑ์์ ์๋์ ๊ทผ์ก๋์ด ์ฒซ ๋ฒ์งธ 5๋ถ์ ๊ตฌ๊ฐ์ ์ํ๋ ๋์์์ ๋น๊ตํ ๋, ๋ค์ฏ ๋ฒ์งธ 5๋ถ์ ๊ตฌ๊ฐ์ ์ํ๋ ์ฌ๋์ ๋์ฌ์ฆํ๊ตฐ์ด ์์ ์ค์ฆ๊ฐ 0.166๋ฐฐ(95% ์ ๋ขฐ๊ตฌ๊ฐ 0.088-0.272)๋ก ๋ํ๋ฌ๋ค. 60์ธ ๋ฏธ๋ง ๋จ์ฑ์์๋ 0.184๋ฐฐ(95% ์ ๋ขฐ๊ตฌ๊ฐ 0.117-0.289), 60์ธ ์ด์์์๋ 0.132๋ฐฐ(95% ์ ๋ขฐ๊ตฌ๊ฐ 0.073-0.289)๋ก ๋ชจ๋ ์ ์ํ ์์ ์ฐ๊ด์ฑ์ ๋ณด์๋ค. ๋์ฌ์ฆํ๊ตฐ์ ๊ตฌ์ฑ ์์์ธ ๊ณต๋ณตํ๋น์ฅ์ , ํ์ ์์น, ๊ณ ์ค์ฑ์ง๋ฐฉํ์ฆ, ๋ฎ์ ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค ๋ฐ ๋ณต๋ถ๋น๋ง ๋ํ ์๋์ ๊ทผ์ก๋์ด ๋ฎ์์๋ก ๊ทธ ์ํ๋๊ฐ ์ฆ๊ฐํ์์ผ๋ฉฐ 60์ธ ๋ฏธ๋ง๊ณผ 60์ธ ์ด์์ ๋จ์ ๊ทธ๋ฃน์์ ๋ชจ๋ ์ ์ํ๊ฒ ๋ํ๋ฌ๋ค. ์ฌ์ฑ์ ๊ฒฝ์ฐ, ํ๊ฒฝ ํ ์ฌ์ฑ์์๋ ์๋์ ๊ทผ์ก๋์ด ์ฒซ ๋ฒ์งธ 5๋ถ์ ๊ตฌ๊ฐ์ ์ํ๋ ๋์์์ ๋น๊ตํ ๋, ๋ค์ฏ ๋ฒ์งธ 5๋ถ์ ๊ตฌ๊ฐ์ ์ํ๋ ์ฌ๋์ ๋์ฌ์ฆํ๊ตฐ์ด ์์ ์ค์ฆ๊ฐ 0.423๋ฐฐ(95% ์ ๋ขฐ๊ตฌ๊ฐ 0.297-0.602)๋ก ์ ์ํ๊ฒ ๋ฎ์์ผ๋ฉฐ, ์๋์ ๊ทผ์ก๋์ด ๋์์๋ก ๋ฎ์ ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค์ ์ ์ธํ ๊ณต๋ณตํ๋น์ฅ์ , ํ์์์น, ๊ณ ์ค์ฑ์ง๋ฐฉํ์ฆ, ๋ณต๋ถ๋น๋ง์ ์ค์ฆ๊ฐ ์ ์ํ๊ฒ ๊ฐ์ํ์๋ค. ํ๊ฒฝ ์ ์ฌ์ฑ์์๋ ์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ์ ์ฐ๊ด์ฑ์ด ์ ์ํ์ง ์์๋ค.
๊ฒฐ๋ก : ๋จ์ฑ ๋ฐ ํ๊ฒฝ ํ ์ฌ์ฑ์์๋ ์๋์ ๊ทผ์ก๋์ด ๋ฎ์์๋ก ๋์ฌ์ฆํ๊ตฐ์ ์ํ๋๊ฐ ๋์์ผ๋ฉฐ ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค์ ์ ์ธํ ๊ฐ๊ฐ์ ๊ตฌ์ฑ ์์๋ค๊ณผ๋ ์์ ์ฐ๊ด์ฑ์ ๋ณด์๋ค. ์ธ๊ณผ์ฑ์ ๋ํ ๋ช
ํํ ๊ทผ๊ฑฐ๋ ์์ง ์๋ ค์ง์ง ์์์ผ๋ฏ๋ก ํฅํ ์ถ๊ฐ์ ์ธ ๊ฒฝ์์ ์ฐ๊ตฌ๊ฐ ํ์ํ ๊ฒ์ผ๋ก ๋ณด์ธ๋ค.๊ตญ๋ฌธ ์ด๋ก i
I. ์๋ก 1
II. ์ฐ๊ตฌ ๋ฐฉ๋ฒ 4
1. ์ฐ๊ตฌ ๋์์ 4
2. ๋์ฌ์ฆํ๊ตฐ์ ์ง๋จ ๊ธฐ์ค 5
3. ๊ทผ์ก๋์ ์ธก์ ๋ฐ ํ๊ฐ 5
4. ๋ณ์๋ค์ ์ธก์ 6
5. ํต๊ณ ๋ถ์ 7
III. ์ฐ๊ตฌ ๊ฒฐ๊ณผ 8
1. ์ฐ๊ตฌ ๋์์์ ์ผ๋ฐ์ ํน์ฑ 8
2.์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ ๋ฐ ๊ตฌ์ฑ ์์๋ค(๊ณต๋ณตํ๋น์ฅ์ , ํ์ ์์น, ๊ณ ์ค์ฑ์ง๋ฐฉํ์ฆ, ๋ฎ์ ๊ณ ๋ฐ๋์ง๋จ๋ฐฑ ์ฝ๋ ์คํ
๋กค, ๋ณต๋ถ๋น๋ง)๊ณผ์ ์ฐ๊ด์ฑ ๋ถ์ 9
3.์๋์ ๊ทผ์ก๋๊ณผ ๋์ฌ์ฆํ๊ตฐ ๊ตฌ์ฑ ์์ ๋ฐ ์ธ์๋ฆฐ ์ ํญ์ฑ ์งํ์์ ์ฐ๊ด์ฑ ๋ถ์ 10
IV. ๊ณ ์ฐฐ 11
์ฐธ๊ณ ๋ฌธํ 16
์๋ฌธ ์ด๋ก 45
๋ถ๋ก 48Maste
Reliability of hip migration index in children with cerebral palsy: the classic and modified methods
OBJECTIVE: To determine reliability and clinical use of two methods of migration index (MI) in CP patients with or without hip dysplasia.
METHOD: The materials included radiographs of 200 hips of children with cerebral palsy. Conventional anteroposterior radiographs of the pelvis were taken with the child in the supine position with standardized methods. Two rehabilitation doctors measured the migration index using two methods. In the classic method, the lateral margin of the acetabular roof was used as a landmark and in the modified method the lateral margin of the sourcil was used as a landmark. Each rater measured the migration index at three separate times with a time interval of at least one week. Intraclass correlation (ICC) was used to test the inter- and intra-rater reliability.
RESULTS: MI shows excellent intra-rater reliability in both the classic and modified methods, but the inter-rater reliability was higher in the classic method than in the modified method. When categorized according to the sourcil classification, inter-rater reliability was higher in the normal sourcil type and lower in the dysplastic sourcil types.
CONCLUSION: Generally, the classic method showed higher reliability than the modified method, even though the reliability of the MI measurement was relatively high with both methods.
KEYWORDS: Cerebral palsy, Hip joint, Migration index, Radiography, Reliabilityope
The Assessment of Reliability of Cognitive Evoked Potential in Normal Person
Objective To evaluate intra-tester reliability of P300 more precisely, this study was designed. Event-related potential (ERP) is the result of endogenous brain response following cognitive stimulus. The P300 component of the human ERP is a positive wave with a latency of 300 ms or greater. Our purpose of this study was to estimate reliability of P300 latency and amplitude with 30 normal persons without head injury, as well as to set up them as the reference values in the event that they would be found to be highly reliable.Methods ERP was performed at three separate times on 30 normal adults in their 20s and 30s. We measured P300 latency and amplitude among ERP.Results P300 latency show excellent reliability with intraclass correlation coefficient (ICC) of 0.81. As to P300 amplitude, reliability was good to fair with ICC of 0.53. Average value of P300 latency was 311.3ยฑ37.0 ms, shorter than reference value of previous study in Korea.Conclusion P300 latency revealed higher reliability than P300 amplitude, although reliability of P300 was confirmed in both component. After further study including precise mechanism, influence factor on measurement and method standardization, it is expected to be an objective indicator to assess the cognitive state and predict prognosisope
Diagnostic Value of Facial Nerve Antidromic Evoked Potential in Patients With Bellโs Palsy: A Preliminary Study
OBJECTIVE:
To assess the practical diagnostic value of facial nerve antidromic evoked potential (FNAEP), we compared it with the diagnostic value of the electroneurography (ENoG) test in Bell's palsy.
METHODS:
In total, 20 patients with unilateral Bell's palsy were recruited. Between the 1st and 17th days after the onset of facial palsy, FNAEP and ENoG tests were conducted. The degeneration ratio and FNAEP latency difference between the affected and unaffected sides were calculated in all subjects.
RESULTS:
In all patients, FNAEP showed prolonged latencies on the affected side versus the unaffected side. The difference was statistically significant. In contrast, there was no significant difference between sides in the normal control group. In 8 of 20 patients, ENoG revealed a degeneration ratio less than 50%, but FNAEP show a difference of more than 0.295ยฑ0.599 ms, the average value of normal control group. This shows FNAEP could be a more sensitive test for Bell's palsy diagnosis than ENoG. In particular, in 10 patients tested within 7 days after onset, an abnormal ENoG finding was noted in only four of them, but FNAEP showed a significant latency difference in all patients at this early stage. Thus, FANEP was more sensitive in detecting facial nerve injury than the ENoG test (p=0.031).
CONCLUSION:
FNAEP has some clinical value in the diagnosis of facial nerve degeneration. It is important that FNAEP be considered in patients with facial palsy at an early stage and integrated with other relevant tests.ope
Aza-Claisen ์ ์๋ฅผ ์ด์ฉํ macrolactam์ ํฉ์ฑ
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ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ฝํ๊ณผ ์ฝํ์ ์กฐํํ์ ๊ณต,1999.Maste
Nanohybrid photocatalyst made of titania nanosheets and zinc oxide nanoparticles via exfoliation-restacking method
Thesis(master`s)--์์ธ๋ํ๊ต ๋ํ์ :ํํ๋ถ ๋ฌผ๋ฆฌํํ์ ๊ณต, 2006.Maste
EGFR T790M ๋์ฐ๋ณ์ด๋ฅผ ์ง๋ ๋น์์ธํฌํ์์์ ๋น ๋์ฌ์ ์ ํด๋ฅผ ํตํ BIBW2992์ ํญ์ข ์ ํจ๋ฅ ์ฆ๋
Dept. of Medical Science/๋ฐ์ฌThe secondary epidermal growth factor receptor (EGFR) T790M is the most common mechanism of resistance to reversible EGFR tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) patients with activating EGFR mutations. Although BIBW2992 has been expected to overcome the resistance to reversible EGFR TKIs due to EGFR T790M mutation, it showed a limited efficacy in recent phase III clinical study. Increased glycolysis, a common feature of most cancer cells, has been considered as a potential target for treatment of cancer. In this study, it was found that the inhibition of glycolysis using 2-deoxy-D-glucose (2DG) improves the efficacy of BIBW2992 in H1975 and PC9-GR cells, the NSCLC cells with EGFR T790M. The combination treatment of 2DG and BIBW2992 induced intracellular ATP depletion in both H1975 and PC9-GR cells, resulting in activation of AMP-activated protein kinase (AMPK), the major energy-sensing kinase. The AMPK activation played a central role in the cytotoxicity by the combined treatment of 2DG and BIBW2992 through inhibition of mammalian target of rapamycin (mTOR). The alteration of AMPK/mTOR signaling pathway by the inhibition of glycolytic metabolism induced downregulation of Mcl-1, a member of anti-apoptotic Bcl-2 family which is critical for survival in H1975 and PC9-GR cells, by translational control. In in vivo xenograft study using PC9-GR cells, the combined treatment of 500 mg/kg 2DG and 5 mg/kg BIBW2992 showed more effective anti-tumor activity than the treatment of 2DG alone or BIBW2992 alone. In conclusion, this study examined whether glucose metabolism inhibition using 2DG enhances the sensitivity to BIBW2992 in NSCLC cells with EGFR T790M. Addition of 2DG increased the sensitivity to BIBW2992 accompanying apoptotic cell death in the cells. The cytotoxicity by the combination treatment of 2DG and BIBW2992 was mediated by Mcl-1 downregulation via alteration of AMPK/mTOR signaling pathway. These data suggest that the combined use of inhibitor of glycolytic metabolism and BIBW2992 is a potential therapeutic strategy for treatment of patients with acquired resistance to reversible EGFR TKIs due to secondary EGFR T790M.prohibitio
๊ฐ๊ณต์ธ์ผ์ ๋์ฌ์ฐ๋ฌผ์ ๊ดํ ์ฐ๊ตฌ
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ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ฝํ๊ณผ ์ฝํ๋ถ์ํํ์ ๊ณต,2003.Maste
CAND1 (Cullin-associated and neddylation-dissociated protein 1) and CSN5 regulate cullin protein stability during Drosophila development
Thesis(masters) --์์ธ๋ํ๊ต ๋ํ์ :์๋ช
๊ณผํ๋ถ,2008. 8.Maste
์น๋งคํ์๋ฅผ ์ํ ์น์ ํ๊ฒฝ์ ๋์ ํ ์ฅ์ธ๊ณต๊ฐ์ค๊ณ์ง์นจ
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ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ํ์กฐ๊ฒฝยท์ง์ญ์์คํ
๊ณตํ๋ถ ์ํ์กฐ๊ฒฝํ์ ๊ณต,2006.Maste
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