15 research outputs found
์ฐฝ์กฐ์ฑ ๋ฐํ์ ์ฌํ์ฌ๋ฆฌํ
ํ์๋
ผ๋ฌธ (๋ฐ์ฌ)-- ์์ธ๋ํ๊ต ๋ํ์ : ์ฌ๋ฆฌํ๊ณผ, 2014. 2. ๋ฏผ๊ฒฝํ.์ฐฝ์กฐ์ฑ์ ์ฌ๋ฆฌํ์ ๊ฐ์ธ์ ์ฐฝ์กฐ์ ๋ฅ๋ ฅ์ ๋ํ ์ฐ๊ตฌ๋ก ์ถ๋ฐํ๋ค. ๊ฐ์ธ ๋ฅ๋ ฅ์ ์ฐ๊ตฌ๋ ํ์ฐ์ ์ฌ๊ณ ์ ์ค์์ฑ์ ๋ฐ๊ฒฌํ๋ ์ฑ๊ณผ๋ฅผ ์ด๋ฃจ์์ผ๋ ๊ฐ์ธ์ ํ์ฐ์ ์ฌ๊ณ ๋ฅ๋ ฅ์ด ๋ฐ๋์ ์ฐฝ์กฐ์ ์ฑ๊ณผ๋ก ๋ฐํ๋์ง๋ ์๋๋ค๋ ์ฌ์ค๋ ๊ณง ๋ฐํ์ก๋ค. ์ด์ ๋ฐ๋ผ ์ฌํ์ ์ผ๋ก ์ธ์ ๋ฐ๋ ์ฐ๋ฌผ์ ์ฐฝ์กฐ๋ก ๊ท๊ฒฐ๋๋ ์ฐฝ์กฐ์ฑ ๋ฐํ์ ์ฅ๊ธฐ์ ์ด๊ณ ์ฌํ์ ์ธ ๊ณผ์ ์ ๋ํ ๊ด์ฌ์ด ํ์ฑ๋์์ผ๋ฉฐ ์ด๋ ์ฐฝ์กฐ์ฑ์ ์ฌํ์ฌ๋ฆฌํ์ผ๋ก ์ฐ๊ฒฐ๋์๋ค. ์ฐฝ์กฐ์ฑ์ ์ฌํ์ฌ๋ฆฌํ์ ์ฐฝ์กฐ์ฑ ๋ฐํ ๊ณผ์ ์ ๊ด์ฌํ๋ ์ฌํ์ ์ด์ง ์์ธ์ ํ๊ตฌํ๊ณ , ์ฌํ์ ํ๊ฒฝ๊ณผ ์ฐฝ์กฐ์ ๊ฐ์ธ์ ๋๊ธฐ์ ์ํธ์์ฉ์ ํจ๊ณผ๋ฅผ ๋ฐํ๋ด๋ ค ํ๋ค. ํนํ Simonton(1999, 2012)์ ๋ค์์ฃผ์์ ์ฐฝ์กฐ์ฑ ๋ชจํ์ ์ฐฝ์กฐ ์์ญ์ ๋ฐ๋ผ ๋ฌ๋ผ์ง๋ ์์ ๋กญ๊ณ ์ ์ฐํ ํ์ฐ์ ๊ณผ์ ๊ณผ ์๋ฐํ ๋ถ์์ , ์๋ ด์ ๊ณผ์ ์ ์๋์ ๋น์ค์ ๋ง์ถ์ด ์ฐฝ์กฐ์์ ์์ฉํ๋ ์ฌํ์ ํ๊ฒฝ๊ณผ ๋๊ธฐ์ ์ํธ์์ฉ์ ํจ๊ณผ ์์์ ๊ตฌ์กฐํํ๋ ํ์ ๋ง๋ จํ๋ค.
์ด ๋
ผ๋ฌธ์ ์ฐฝ์กฐ์ฑ์ ์ฌํ์ฌ๋ฆฌํ์ ๋ฐํ์ผ๋ก ์ฐ๋ฆฌ๋๋ผ์ ํ๋ ์์ค ์์ญ๊ณผ ๋ฏธ์ ์์ญ์ ์ฐฝ์กฐ์ฑ ๋ฐํ์ ํด๋ช
ํ๊ณ ์ ํ ์ฐ๊ตฌ ์์
์ด๋ค. ์ด๋ฅผ ํตํด ์์ง๊น์ง ์ฌ๋ฆฌํ์ ์ฐ๊ตฌ ๋์์ผ๋ก ์ฃผ๋ชฉ๋ฐ์ง ๋ชปํ ์ฐ๋ฆฌ๋๋ผ์ ๋ ์์ ์์ญ์ ๊น์ด ์๊ฒ ๊ธฐ์ ํด๋ด๊ณ , ์ด ๊ณผ์ ์์ ๋ค์์ฃผ์์ ์ฐฝ์กฐ์ฑ ๋ชจํ์ ์ค์ฌ์ผ๋ก ์ฐฝ์กฐ์ฑ ๋ฐํ์ ํ๊ฒฝ๋ก ๊ณผ ๋๊ธฐ๋ก ์ ์ฐ๊ฒฐํ๋ ค๋ ๋
ธ๋ ฅ์ ๊ธฐ์ธ์๋ค.
์ฐ๊ตฌ 1์ ์ฐ๋ฆฌ๋๋ผ ํ๋ ์์ค๊ณผ ๋ฏธ์ ์์ญ์์ ์ด๋ฆ ์๋ ์ธ๋ฌผ๋ค์ ๋์์ผ๋ก ๋ฌธํ ์ฐ๊ตฌ๋ฅผ ์งํํ์๋ค. ์ฐ๊ตฌ 1-1์์๋ ์์ค๊ณผ ๋ฏธ์ ๋ ์์ญ ์ฐฝ์กฐ์์ ๋์ด์ ๋ฐ๋ฅธ ๋ช
์ฑ ๋ณํ๋ฅผ ๊ด์ฐฐํ์ฌ ์ด๋ค์ด ์๊ตฌ์ ์ฌ๋ฌ ์์ญ๊ณผ ๋น๊ตํ์ ๋ ๋น๊ต์ ๋น ๋ฅธ ์์ ์ ๋์ ๋ช
์ฑ์ ํ๋ํ๋ ๊ฒ์ ํ์ธํ์๋ค. ๋ค์์ฃผ์์ ์ฐฝ์กฐ์ฑ ๋ชจํ์ ์๊ฑฐํ์ฌ ์ด ๊ฒฐ๊ณผ๋ ๋ ์์ญ์ ์ฐฝ์กฐ์๊ฐ ํ์ฐ์ ๊ณผ์ ์ ๋น์ค์ ๋๊ณ ๋ค์ํ ์ฐ๋ฌผ์ ๋น ๋ฅธ ์ฐ์ถ์ ๊พํจ์ ๋ณด์ฌ์ฃผ๋ ๋จ์๋ก ํด์๋์๋ค. ๋ํ ์์ค ์์ญ์ ๋ฏธ์ ์์ญ์ ๋นํด ๋ช
์ฑ ํ๋ ์์ ์ด ๋ ๋น ๋ฅธ ๊ฒ์ผ๋ก ๋ํ๋ ์์ค๊ฐ์๊ฒ์ ํ์ฐ์ ๊ณผ์ ๋ฐ ๊ทธ์ ๊ด๋ จ๋๋ ํ๊ฒฝ์ ์ํฅ๊ณผ ๋๊ธฐ ์ญ๋์ด ๋ ๋๋๋ฌ์ง ๊ฒ์ผ๋ก ์์๋์๋ค. ์ด์ด์ง๋ ์ฐ๊ตฌ 1-2์์๋ ๋ค์ฑ๋ก์ด ์ง์๊ณผ ์๊ฐ์ ๊ณต๊ธํจ์ผ๋ก์จ ํ์ฐ์ ๊ณผ์ ์ ๋๋ ์ฌ๋ฌ ์ฌํ ํ๊ฒฝ ์์ธ์ด ๋ ์์ญ ๋ชจ๋์์ ๊ธ์ ์ ํจ๊ณผ๋ฅผ ๋ํ๋์ ํ์ธํ์์ผ๋ ํนํ ์์ค๊ฐ๊ฐ ์ด ๊ฐ์ ํ๊ฒฝ์ ์ํฅ์ ๋ ํฌ๊ฒ ๋ฐ๋๋ค๋ ์ฆ๊ฑฐ๋ ๋ฐ๊ฒฌํ์ง ๋ชปํ๋ค.
์ฐ๊ตฌ 2์์๋ ํ์ฌ ์์ค๊ณผ ๋ฏธ์ ์์ญ์์ ํ๋ ์ค์ธ ์ฐฝ์กฐ์๋ฅผ ๋์์ผ๋ก ๋ฉด๋ด ์ฐ๊ตฌ๋ฅผ ์งํํ์ฌ ํนํ ์ด๋ค์ ์ฐฝ์กฐ ๊ณผ์ ์ ์ ๋ณ์์ ์๋ํ๋ ๋๊ธฐ์ , ์ ์์ ์ญ๋์ ํด๋ช
ํ๊ณ ์ ํ๋ค. ๊ทธ ๊ฒฐ๊ณผ ์์ค๊ฐ ์ฐธ์ฌ์๋ค์ ํ์ฐ์ ๊ณผ์ ๊ณผ ๊ธ์ ์ ๊ด๊ณ๋ฅผ ๋งบ๋ ๋ชฐ์
(flow)์ ์ค์ํ๊ณ ๋ชฐ์
์ ๋๋ ๋ฐฉ๋ฒ์ ๊ฐ๊ตฌํ๋ ๊ฒ์ ๋ฐ๊ฒฌํ์์ผ๋ฉฐ ์ด๋ ์ฐ๊ตฌ 1์ ๊ฒฐ๊ณผ์ ๋ถํฉํ์๋ค. ๋ฐ๋ฉด ๋ฏธ์ ๊ฐ ์ฐธ์ฌ์๋ค์ ํนํ ์์ญ์ ๊ตฌ์ฑ ๋ด์ฉ์ ๋ฉด๋ฐํ ๋ถ์ํ๊ณ ์์ญ์ ๋ํ ๊ธฐ์ฌ๋ฅผ ๊ฐ์กฐํ๋ ๋ฑ ์๋ ด์ ์ธ ๊ณผ์ ์ ๋ณด๋ค ์ค์ํ๋ ๋ชจ์ต์ ๋ณด์์ผ๋ฉฐ ์ด๋ ์ฐ๊ตฌ 1-1์ ๋ํ๋ ๋ ์์ญ์ ๊ฒฝ๋ ฅ ํ์ง์ ์ฐจ์ด๋ฅผ ์ ์ค๋ช
ํด์ฃผ์๋ค.
๋ง์ง๋ง์ผ๋ก ์ฐ๊ตฌ์ ์ข
ํฉ ๋
ผ์์์ ์ด ๋
ผ๋ฌธ์ด ํ๊ตญ ์์ค๊ณผ ๋ฏธ์ ์์ญ์ ๊ธฐ์ ํด๋ธ ๋ฐ์ ์ฐฝ์กฐ์ฑ ์ฌํ์ฌ๋ฆฌํ์ ๊ธฐ์ฌํ ๋ฐ๋ฅผ ์ ๋ฆฌํ๊ณ ๊ทธ ํจ์๋ฅผ ๋
ผํ์์ผ๋ฉฐ ๋ฏธ๋ ์ฐ๊ตฌ์ ๋ฐ์ ๋ฐฉํฅ์ ์ ์ํ์๋ค.์ ๋ก 1
์ฐ๊ตฌ ๋ชฉ์ 1
์ฐฝ์กฐ์ฑ ์ฐ๊ตฌ์ ๋ณ์ฒ: ๊ฐ์ธ ๋ฅ๋ ฅ์์ ์ฌํ์ ์ญ๋์ผ๋ก 3
๊ณผํ์ ์ฐฝ์กฐ์ฑ ์ฐ๊ตฌ์ 1์ธ๋์ ํ์ฐ์ ์ฌ๊ณ 3
์ฐฝ์กฐ์ฑ ๋ฐํ ๊ณผ์ ๊ณผ ์ฌํ์ ์ฒด๊ณ: ์ฐฝ์กฐ์ฑ ์ฌํ์ฌ๋ฆฌํ์ ํ์ฑ 8
์ฐฝ์กฐ์ฑ ๋ฐํ์ ์ฌํ์ฌ๋ฆฌํ 10
์ฐฝ์กฐ์ฑ์ ๊ณผํ์ ์ ์ 10
์ฐฝ์กฐ์ฑ ์ฌํ์ฌ๋ฆฌํ์ ๋ฐฉ๋ฒ๋ก 13
๊ฐ์ธ์ ์๋ก์ ์ฐ์ถ์ ์์ฉํ๋ ์ฌํ์ ํ๊ฒฝ 16
๊ฐ์ธ์ ์๋ก์ ์ฐ์ถ์ ์์ฉํ๋ ๋๊ธฐ ์์ธ๊ณผ ๊ทธ ์ฌํ์ ํ๊ฒฝ 18
์์ญ ํจ๊ณผ์ ์ด๋ก : ์ฐฝ์กฐ์ฑ ์ฌํ์ฌ๋ฆฌํ์ ์ข
ํฉ 24
์์ญ์ ์ค์ฒด์ ํจ๊ณผ 24
๋ค์์ฃผ์์ ์ฐฝ์กฐ์ฑ ๋ชจํ 28
์์ญ๊ณผ ์ฌํ์ ํ๊ฒฝ 33
์์ญ๊ณผ ๋๊ธฐ์ ์ํธ์์ฉ 36
ํ๊ตญ ํ๋ ์์ค๊ณผ ๋ฏธ์ ์ ์ญ์ฌ์ ๋ฐฐ๊ฒฝ๊ณผ ์ฐ๊ตฌ ์์ธก 39
์ฐ๊ตฌ ๊ตฌ์ฑ 42
์ฐ ๊ตฌ 1 45
์ฐ๊ตฌ 1-1: ํ๊ตญ ํ๋ ์์ค๊ณผ ๋ฏธ์ ์ ๊ฒฝ๋ ฅ ํ์ง์ 45
1. ๋ฐฉ๋ฒ 45
2. ๊ฒฐ๊ณผ ๋ฐ ๋
ผ์ 48
์ฐ๊ตฌ 1-2: ์ฌํ์ ํ๊ฒฝ์ ํจ๊ณผ 53
1. ์ ์ฐจ 53
2. ๊ฒฐ๊ณผ 56
์ฐ๊ตฌ 1 ๋
ผ์ 66
์ฐ ๊ตฌ 2 69
๋ฐฉ๋ฒ 69
์ฐ๊ตฌ 2-1: ์์ค๊ฐ์ ์ฐฝ์กฐ์ฑ ๋ฐํ ๊ณผ์ 74
1. ์์ค๊ฐ๊ฐ ๋๊ธฐ 74
2. ์์ค๊ฐ๋ก ์ด๊ธฐ 80
3. ์์
ํ๊ธฐ 86
์ฐ๊ตฌ 2-2: ๋ฏธ์ ๊ฐ์ ์ฐฝ์กฐ์ฑ ๋ฐํ ๊ณผ์ 94
1. ๋ฏธ์ ๊ฐ๊ฐ ๋๊ธฐ 94
2. ๋ฏธ์ ๊ฐ๋ก ์ด๊ธฐ 97
3. ์์
ํ๊ธฐ 107
์ฐ๊ตฌ 2 ๋
ผ์ 112
์ข
ํฉ ๋
ผ์ 121
์ฐธ๊ณ ๋ฌธํ 127
Abstract 142Docto
Determinants of emotion regulation motive : focusing on the effect of daily mood
ํ์๋
ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ฌ๋ฆฌํ๊ณผ ์ฑ๊ฒฉ์ฌ๋ฆฌ์ ๊ณต,2005.Maste
Development of CDR model for lifetime health management based on EHR
๋ณด๊ฑด์ ๋ณด๊ด๋ฆฌํ๊ณผ/์์ฌ[ํ๊ธ]
์ด ์ฐ๊ตฌ๋ HL7์์ ์ ์ํ๋ ํ์ค ์๋ฃ์ ๋ณด ๊ธฐ์ ์ ์ ์ฉํ์ฌ, ๊ตญ๋ฏผ๊ฐ์ธ ์์ ๊ฑด๊ฐ๊ด๋ฆฌ ํจ์จ์ ๋์ด๊ณ , ํ์๊ฐ ๋ค๋ฅธ ๋ณ์์ผ๋ก ์ด๋ํ ๋ ์ง๋ฃ์ ์ฐ์์ฑ์ ๋ณด์ฅํ๊ณ ์ ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์ ๊ฑด๊ฐ๊ฒ์ง๊ธฐ๋ฐ CDR ๊ธฐ๋ณธ ๋ชจํ์ ์ ์ํ์๋ค. ์ด๋ฅผ ์ํ์ฌ ๋ฌธํ๊ณ ์ฐฐ์ ํตํ์ฌ ASP.Net ํ๋ก๊ทธ๋จ๊ณผ C++, XML ์ธ์ด์ ์ต์ ๊ธฐ์ ์ ์ ์ฉํ์ฌ CDR์ ๊ฐ๋ฐํ์๋ค.CDR์ ๊ฐ๋ฐ๊ณผ ํ๊ฐ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค.์ฒซ์งธ, ์ ์ฑ
์๋ฆฝ์, ๊ตญ๋ฏผ๊ฐ์ธ, ์์์ฐ๊ตฌ์์๊ฒ ๊ฑด๊ฐ๊ฒ์ง ๋ด์ญ, ์ง๋ฃ๋ด์ญ, ์์๊ธฐ๊ด์ ํด์์์ฝ์ ๋ณด, ์ธ๊ตฌ์ ์ฌํ๊ฒฝ์ ์ ํต๊ณ์ ๊ด๋ จ๋ 11๊ฐ ์ฐ๊ณ๊ธฐ๊ด ์ ๋ณด๋ฅผ ์ค์๊ฐ์ผ๋ก ์ ๊ณตํ๊ธฐ ์ํ์ฌ ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์ ๊ฑด๊ฐ๊ฒ์ง ๊ธฐ๋ฐ EHR ๋ชจํ์ ์ค๊ณํ์๋ค.๋์งธ, CDR๋ชจํ ๊ฐ๋ฐ์ ํ์ํ ๊ธฐ์ด๋ฐ์ดํฐ๋ ๊ฐ์
์(์๊ฒฉ)ยท๋ณดํ๋ฃ ์ ๋ณด 18๊ฐ ํญ๋ชฉ, ์๋ฃ์ด์ฉ ์ ๋ณด 11๊ฐ ํญ๋ชฉ, ๊ฑด๊ฐ๊ฒ์ง์ ๋ณด 108๊ฐ ํญ๋ชฉ, ์์๊ธฐ๊ด์ ๋ณด 16๊ฐ ํญ๋ชฉ, ํด์์์ฝ์ ๋ณด 16๊ฐ ํญ๋ชฉ์ ๋์ถํ์๋ค.์
์งธ, ๊ฑด๊ฐ๊ฒ์ง๊ธฐ๋ฐ์ EHR ๊ตฌํ์ ์ํด ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์ ํ์คํ๋ ์์์ CDA๋ก ๊ตฌ์ฑํ๊ณ ๊ธฐ์กด DW์ DBํ
์ด๋ธ๊ณผ ์ฐ๊ณํ์ฌ 3๊ณ์ธต์ CDR์ ๊ตฌ์ถํ์๋ค.๋ท์งธ, CDR์ ๊ตฌ์ถํ ํ ์ง๋ 2๋
๋์ ์๊ตฌ์ ๋ณด๋ฅผ ๋ถ์ํ์ฌ ๋ค ๋น๋ ์ง๋ฌธ์ ์ ์ ํ์ฌ CDR์ ํจ์จ์ฑ์ ํ๊ฐํ ๊ฒฐ๊ณผ ๊ธฐ์กด DW์์คํ
๋ณด๋ค ์ฟผ๋ฆฌ์ ์์
๊ณผ์ ์ด 37๋จ๊ณ์ 5๋จ๊ณ๋ก ๊ฐ์ํ๋์๊ณ , ์์์๊ฐ์ 15๋ถ 48์ด์์ 51์ด๋ก ๊ฐ์ ๋ ๊ฒฐ๊ณผ๋ฅผ ๋ณด์๋ค.์ต์ข
์ ์ผ๋ก ์ด ์ฐ๊ตฌ๊ฒฐ๊ณผ๋ ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์ ๊ฑด๊ฐ๊ฒ์ง๊ธฐ๋ฐ์ EHR ๊ตฌํ์ ์ํ CDR์ ์๊ฐ๊ณผ ๋น์ฉ์์ ํจ์จ์ฑ ์๋ ์ค๊ณ๋ชจํ์์ ์ฆ๋ช
ํ์๋ค.์ด ์ฐ๊ตฌ๋ ์ํ์ง์์ ์ ํฉํ ๋ถ๋ฅ์ฒด๊ณ์ ๋ํ ๊ณ ๋ ค๊ฐ ์์ด ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์์ ์ฌ์ฉ์ค์ธ ์ ๋ณด ๋ถ๋ฅ์ฒด๊ณ๋ฅผ ์ ์ฉํ์๊ณ , EMR ์๋ฃ ํตํฉ๊ณผ์ ์์ ์ผ๊ฐ ๋ณ์์ ํด์์์ฝ ํ์๋ง์ ์ฌ์ฉํ์ฌ ๊ฐ๋ฐํ์๋ค๋ ์ ํ์ ์ ๊ฐ์ง๋ ์ค์ ๊ตญ๋ฏผ๊ฑด๊ฐ๋ณดํ๊ณต๋จ์ ์
๋ฌด์ ์ ์ฉํ์ฌ ํจ๊ณผ๋ฅผ ๊ฒ์ฆํ์ฌ ์๊ฐ๊ณผ ๋น์ฉ์์ ํจ์จ์ฑ ์๋ ๋ชจํ์ ๋์ถํ์๋ค๋ ์ ์์ ์์๋ฅผ ๊ฐ์ง๋ค๊ณ ํ๋จ๋๋ค.ํฅํ ๊ฐ์ธ๊ฑด๊ฐ์๋ฐฉ์๋น์ค์ ์ฐ๊ตฌ์์ ๊ฑด๊ฐ๊ฒ์ง ์ ๋ณด์ ๊ทผ์ฑ๊ณผ ํธ์ด์ฑ์ ๋์ด๋ ๋ฒ, ์ ๋์ ๋ฌธ์ ๋ฅผ ํด๊ฒฐํด์ผ ํ ๊ฒ์ด๋ค.
[์๋ฌธ]This study presents the CDR(clinical document repository) model for lifetime health management of health insurance beneficiaries and their families by using physical examination database and utilization database at NHIC(National Health Insurance Cooperatives). The CDR may help improve continuity of medical treatment by applying HL7 standards when patients are transferred to other hospitals. Based on the literature review, the CDR was developed by using the latest technologies such as ASP .Net program, C++, and XML language.The CDR was developed and evaluated as follows:First, EHR model was developed by using physical examination database and utilization database at NHIC in order to provide information on physical examination data, health records, discharge summary, and socio-economic data for 11 related agencies to policy makers, health researchers, and beneficiaries.Second, data items for CDR model were determined from physical examination database and utilization database. They were: 18 items on eligibility and insurance fee, 11 items on health care utilization, 108 items on physical examination data, 16 items on healthcare institution data, and 16 items on discharge summary data.Third, a standardized document for EHR was developed by using CDA(clinical document architecture), and 3 layer-CDR was developed by integrating with database table from the existing data warehouse.Finally, a performance of CDR was evaluated by comparing its processing time with that of data warehouse using the most frequent query for the past two years. As a result, the work process for this query has reduced from 37 steps to 5 steps, and its processing time has reduced from 15 minutes 48 seconds to only 51 seconds.In conclusion, the results of this study showed that CDR for the physical examination-based EHR performed better than the existing data warehouse and that it is a cost-efficient alternative for developing EHR.In the future, more studies on improving accessibility of CDR and EHR for beneficiaries and researchers are needed in order to help them better utilize these data for their health promotion and the related research. This may require not only technical efforts as well as legal studies.ope
Synoptic characteristics for Korean regional heavy snowfall when Siberian High extends to the peninsula
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ผ๋ฌธ (์์ฌ)-- ์์ธ๋ํ๊ต ๋ํ์ : ์ฌํ๊ต์ก๊ณผ(์ง๋ฆฌ์ ๊ณต), 2011.2. ๋ฐ๋ณ์ต.Maste
Effects of renal decapsulation on renin-angiotensin-aldosterone system in renal hypertensive dogs
In 8 mongrel dogs , renal hypertension was produced
by partial constriction of their renal artery and 3
weeks after the constriction of renal artery, reoperation,
decapsulation of both kidneys were done in
every hypertensive dogs. The changes in blood
pressure and body weight were measured every week
during the course of experiment for 5 weeks, and
also simultaneous blood samples were drawn for
analysis of activities of plasma reninl steroid, aldosterone,
sodium and potassium concentrations.
The results obtained were as follows:
1. The control mean systolic pressure before operation
was 136ยฑ22 mmHg. After constriction of renal
artery, it was greatly increased within 3 days and
rised up to 3 weeks continuously when maximum
mean value of 264ยฑ12 mmHg was measured. However
, blood pressure in every hypertensive dogs were
gradWllly decreased and return to normal 2 weeks
after renal decapsulation.
2. The control plasma renin activities were aver
aged 132ยฑ57 ng%/hr. After renal constriction, the
plasma renin activities rised proportionately with the
rise of blood pressure up to 3 weeks. The maximal
value at 3 weeks after operation was 2. 5 times of
control value. Renin activities were also decreased
to almost normal value within 2 weeks by renal
decapsulation. . .f
3. There are no signifi๋ฐ['t ๏ผ ~ variations in total
blood steroid either after renal constriction or renal
decapsulation. Aldosterone levels were however
proportionately increased or decreased according to
the blood renin activities. While , blood Na level
was increased and K levels were decreased during
renal arterial constriction period but their relations
hips were reversed after renal decapsulation.
4. The changes in body weight after constriction
of renal artery were increased from 11.8ยฑ0. 8kg in
control to 12. 9ยฑ0. 8 kg. Thereafter these mean
values were tend to normal value within 2 weeks
after renal decapsulation. The increase in body
weight is supposed to mean the degree of edema due
to Na retension by aldosterone.
From the above data it can be reconfirmed that
remarkable disordered function in R-A-A system in
the renal hyPertension were same with those in the
typical secondary aldosteronism and functions of
R-A-A system in the renal hypertensive dogs also
tend to return to normal by renal decapsulation
Changes in Plasma Renin Activity at Various Postures in Rabbits
In order to investigate the changes in plasma renin
activity at various postures in rabbits, the experi
mental animals were maintained at prone, side.
upright, and headside down postures for 10 hours.
Plasma renin activity was measured by the method
of radioimmunoassay.
The data obtained were as follows:
1) At prone posture, the plasma renin activity
was 14.72ยฑ3. 49 nanogram per 100ml plasma per
hour. which was regarded as resting plasma renin
activity.
2) At side posture, the plasma renin activity was
46.60ยฑ5. 41 ng/100ml plasma/hr, which was signi
ficantly higher than that of resting plasma renin
activity.
3) At upright posture, the plasma renin activity
was 45.82ยฑ11. 51 ng/100ml plasma/hr, which was
also significantly higher than that of resting level
4) At headside down posture, the plasma renin
activity was 44. 16ยฑ10. 33 ng/1ooml plasma/hr, which Was also significantly higher than that of resting
plasma leve l.
From the adove results. it was concluded that the
postures other than normal prone position in rabbits
stimulated the release of renin in the kidne
Renal Autoregulation in the Perfused Kidney of Rabbit
The phenomenon of renal autoregulation was
investigated in the rabbits weighed from 1.8 to 2.3
kg.
An isolated kidney from a experimental rabbit was
perfused with the blood coIIected from the other
one rabbit and the renal blood flow was measured
in various arterial perfusion pressures.
From the perfusion studies in connection of the
isolated rabbit kidney with the perfusion system,
foIIowing results were obtained:
1) The autoregulation was continued for 30
minutes from the time of perfusi~n ๏ผ and deteriora
tion was noted rapidly.
2) The change in kidney weight was noted after
the experiment. The increase in weight was revealed
by the 3.2%. (from 6.54 gm to 6.75 gm)
3) The range of autoregulation was from the 110โข
120 mmHg of renal perfusion pressure to the 180โข
190 mmHg.
4) Within the range of autoregulation, the mean
renal blood flow was 1.25 mljgm/min.
5) Total renal resistance calculated was increased
proportionately within the range of autoregulation.
However, that was inversely related to changes in
renal perfusion pressure
Renal Responses to the Changes in Volume and Osmolar Concentration of Extracellular Fluid
Sixty-six healthy medical students were divided
into 5 groups and induced the changes in volume
and/or osmolar concentration of extracellular fluid:
The first group (water group) ingested 1.000ml
water; The second group (saline group) ingested
1.000 ml isotonic saline solution; The third group
(ADH group) ingested 600 ml water as a priming dose
and thereafter 200 ml water every 30 minutes. and
ADH(lOmU) was injected intramuscularly 2 hours
after the start of the experiment; The fourth group
(urea group) ingested 50 grams of urea; The fifth
group (beer group) ingested 1. 000 ml beer(4% ethyl
alcohol).
Urine was collected every 30 minutes. Urinary
volume. osmolarity and the excretion of sodium ions
were measured.
The results obtained are summerized as follows:
1. The water group showed that the urinary flow
begins to increase within 30 minutes and reached
its peak at 90 minutes after the start of the ex
periment. The total volume excreted for 2 hours
was approximately 1, 000ml. Urinary osmolaritฮณ and sodium ion concentration decreased almost
in proportion to the increase of urinary flow.
2. The saline group revealed that the diuresis was
moderate and greatly prolonged. The volume of
urine eliminated for 3 hours was less than 500
mI. Urinary osmolarity and especially sodium
ion concentration increased in parallel with the
increase of urinary flow.
3. The ADH group showed that the urinary flow
increased as the water group, but the decrement
of urinary flow rapidly developed within 30
minutes after ADH injection and the urinary
flow reached subnormal level 60 minutes after
the injection.
4. The urea group revealed that the changes in
urinary flow were in parallel with the changes
in solute, especially urea excretion. Maximal
urinary flow developed 45 minutes after the
start of the experiment and then decreased
gradually.
5. The beer group revealed that the pattern of the
urinary flow was similar to that of the water
group, but the volume of urine eliminated for
2 hours was more than that of the water group
(1. 100mI)