鸡尾酒抗体D2-40/CD34-CK对淋巴结检出数量不足结直肠癌标本的临床病理评价

目的探讨鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色在淋巴结检出数量不足的结直肠癌(colorectal cancer,CRC)标本脉管侵犯评估中的应用及意义。方法收集133例淋巴结检出数量<12枚的CRC标本,分别行HE染色及鸡尾酒抗体双重免疫组化染色,比较两种方法在脉管侵犯筛查效果中的差异,并分析应用鸡尾酒抗体免疫组化染色证实的脉管侵犯与临床病理特征及患者总生存期(overall survival,OS)的关系。结果 (1)鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色及HE染色对脉管侵犯的检出率分别为42. 9%(57/133)和21. 8%(29/133),差异有显著性(P <0. 001)。(2)鸡尾酒抗体D2-40/CD34-CK双重免疫组化法证实的脉管侵犯与Dukes分期、浸润深度、临床分期、淋巴结转移、肿瘤出芽相关(P <0. 05)。(3)脉管侵犯、侵犯位置深度、程度及脉管侵犯灶数≤2个灶且癌栓细胞数量≥5. 5个与患者OS密切相关(P <0. 05)。结论鸡尾酒抗体D2-40/CD34-CK双重免疫组化染色对脉管侵犯评估优于常规HE染色切片观察,与肿瘤分期、淋巴结转移及出芽情况密切相关,是患者预后的独立影响因素,可作为淋巴结检出数量不足CRC病例的补充检测指标。国家自然科学基金青年科学基金(81301787

MCTミルクが有効であった蛋白漏出性胃腸症の乳児例

We report a case in a previously healthy 5 months boy of protein-losing gastro enteropathy, presenting with poor feeding and hypoalbuminemia. At the hospitalization, although his albumin was 2.0g/dl, he had no proteinuria or cardiac dysfunction. Three days after his hospitalization, he got edema and his albumin dropped 1.3g/dl. Scintigraphy using 99mTc-labeled human serum albumin showed the leakage of albumin from the digestive tract and he was diagnosed as Protein-losing gastro enteropathy. Primary Intestinal Lymphangiectasia was diagnosed, since inflammatory bowel diseases and secondary obstruction of lymph ducts were negative from the results of blood tests, endoscopy and pathology. The present case was successfully treated by MCT milk. Endoscopy is useful not only for differential diagnosis of protein-losing gastro enteropathy but also for the improvement of the compliance of the patient for appropriate diet therapy owing to the final diagnosis. In case of children, an early diagnosis and an appropriate treatment is important in order not to cause the delay of growth

外洋域動物プランクトン中の福島原発事故由来放射性セシウムの時間変動

http://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr11-03/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr11-05/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr10-08/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr12-02/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr13-04/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr14-04/

遠洋域動物プランクトン群集中の放射性セシウム

http://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr11-03/ehttp://www.godac.jamstec.go.jp/darwin/cruise/mirai/mr11-08_leg3/