关于天然多糖及其寡糖研究的一点浅见

多糖是大自然赐予人类可持续获得的功能化合物宝库。研究发现自然界丰富、结构各异的多糖通常是由32种单糖组成,动、植物及微生物多糖除含有一些相同单糖组成之外,还含有其特殊的单糖组成(常见如:植物果胶中半乳糖醛酸、动物和微生物中的几丁质、动物中的肝素和透明质酸等)。海洋与陆地天然多糖也存差异(如:褐藻中特有的岩藻聚糖及绿</p

糖生物工程与大健康产业

大健康产业已成为带动整体国民经济发展的巨大动力。十九大提出&quot;实施健康中国战略&quot;,指出&quot;人民健康是民族昌盛和国家富强的重要标志&quot;,&quot;健康中国&quot;已正式写入国家&quot;十三五&quot;规划。糖科学与糖生物工程是大健康产业的重要支柱之一。糖生物工程是研究糖类物质的结构、功能、制备技术及其应用的一门学科。近三十年来,糖链功能研究技术手段不断发展,大量糖链结构及其生物学功能被揭示。糖链与生物体生长、发育及疾病过程的密切关系被逐步发现,</p

甲壳素生物降解制备低聚氨基葡萄糖

低聚氨基葡萄糖是具有调控植物生长，防治植物病害，调节人体免疫，抑制肿瘤等功能的寡糖原料产品，应用低聚氨基葡萄糖研制的生物农药“好普“对水果，蔬菜病害的防治效果达到80％以上，研制的保健食品“奥利奇善”胶囊和“派其安”胶囊具有调节免疫及促排铅的作用，已实现产业化

Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides derived from porcine hemoglobin

Animal blood is potentially an untapped source of drugs and value-added food production. More than 400 million pigs are slaughtered each year but porcine blood is usually discarded in China. This study describes the isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from porcine hemoglobin. The most active hydrolysate was obtained from the peptic digestion of porcine hemoglobin. After the purification of ACE-inhibitory peptides with Sephadex LH-20 gel chromatography and reversed-phase high-performance liquid chromatography (RP-HPLC) on C-18 column, two active fractions were obtained. They were analyzed by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry (MALDI-TOF/MS) and electrospray ionization tandem mass spectrometry (ESI-MS/MS). They were LGFPTTKTYFPHF and VVYPWT, corresponding to the 34-46 fragment of the a chain and the 34-39 fragment of the a chain of porcine hemoglobin, with IC50 values of 4.92 and 6.02 wM, respectively. They were the first found from porcine hemoglobin; in particular, LGFPTTKTYFPHF was a novel ACE-inhibitory peptide. In addition, the purified ACE inhibitors both competitively inhibited ACE, and maintained inhibitory activity even after incubation with gastrointestinal proteases. This suggests that these peptides might have a potential antihypertensive effect. (c) 2006 Elsevier Inc. All rights reserved