环状RNA:消化道肿瘤诊治的新靶点

环状RNA(circular RNA,circ RNA),作为非编码RNA(non-coding RNA)的重要成员,广泛存在于包括人类在内的多种原核及真核生物体内,对生命活动具有重要的调控作用,已成为非编码RNA研究领域的热点。与线性RNA相比,circ RNA呈共价闭合环状结构,具有结构稳定、序列保守、组织特异性、时空特异性等特点,在包括消化道肿瘤在内的多种疾病中发挥重要作用。circ RNA可通过竞争性吸附mi RNA、调控基因表达、参与蛋白质翻译等多种途径,参与肿瘤的发生发展,在肿瘤早期诊断、疗效监测、分期分型、预后、耐药逆转等方面具有一定的潜能,有望成为消化道肿瘤诊断和治疗的新靶点。本文就circ RNA的结构特点、调控机制及其在消化道肿瘤的相关研究进展进行综述。广东省医学科学基金资助项目(No.A2018011)~

螺内酯联合贝前列腺素钠对2型糖尿病肾病患者肾功能的影响

目的探讨贝前列素钠联合螺内酯治疗2型糖尿病肾病的临床研究。方法选取2型糖尿病肾病患者94例,按照随机数字表法随机分为观察组47例与对照组47例。对照组采取单用贝前列素钠治疗,观察组在对照组基础上结合螺内酯联治疗。比较两组治疗前后尿素氮、血肌酐、24 h尿微量清蛋白(m ALB)和肾小球滤过率(GFR)变化。结果观察组总有效率(93.62%)高于对照组(72.34%)(P <0.05)。两组治疗后尿素氮和血肌酐水平均降低(P <0.05);观察组治疗后尿素氮和血肌酐水平低于对照组(P <0.05)。两组治疗后mALB降低而GFR上升(P <0.05);观察组治疗后m ALB低于对照组而GFR高于对照组(P <0.05)。结论贝前列素钠联合螺内酯治疗2型糖尿病肾病患者疗效显著,能改善患者肾功能

Rules Mining Research on the Eye Features Computation in the Spirit Diagnosing of TCM

中医客观化中有一个很重要的问题是根据量化的人体特征推导出人体的状态.提出了一种用于中医察目望神客观化中从眼部特征推导出人体“神“的状态的规则挖掘方法.首先给出了视频采集方法,接着使用类-属性依赖最大化方法(CAIM)对眼部特征数据进行离散化形成规则挖掘中的属性区间,然后使用云模型进行关联规则挖掘得到大量候选规则,再对3种互补的规则裁剪方法进行修改和组合用于候选规则的整理,并形成最终的规则集合.利用交叉验证法检验规则挖掘的效果,得到了93%的平均精确度,达到了很好的效果.Quantitative features reflecting the human body′s appearance are very helpful in diagnosing human′s health state in Traditional Chinese Medicine(TCM).This paper presents a novel application of eye features computation in the Spirit diagnosing,for which rules describing "the Spirit" state are mined by the quantitative features regarding the human eyes.With videos capturing the eye condition during a short time,a set of eye features are extracted.On the basis of it,attribute intervals of the eye feature space are generated by the CAIM.Then,a various of candidate rules are mined by the association rule mining based on the Cloud model.Finally,three complementary rule-pruning methods are modified and combined to trim the boring candidate rules.The cross validation test for mined rules reaches the average accuracy of 93%,which shows the good performance of the proposed method.国家自然科学基金项目(60672018);深圳市科技计划基础研究项目(JC200903180630A

Application of fine nursing management for patients undergoing simultaneous bilateral lobectomy (精细化护理干预在同期双侧肺叶切除术患者中的应用)

Objective To investigate the effect of f fine nursing management for patients undergoing simultaneous bilateral lobectomy. Methods Totally 52 patients under simultaneous bilateral lobectomy were randomly divided into the control group and observation group, with 26 cases in each group. The control group received routine nursing interventions during perioperative period. The observation group was given fine nursing management. The indwelling time of catheter, length of postoperative hospital stay, hospitalization costs and postoperative complications were recorded. Results The indwelling time of drainage tube and length of postoperative hospital stay in the observation group were shorter than those in the control group(P＜0. 05). There was a case of pneumothorax, 1 case of stage I pressure injury, 5 cases of arrhythmia, 2 cases of breathing difficulties and 2 cases of incision infection in the observation group. There was a case of pneumothorax, 3 cases of stage I pressure injury, 5 cases of arrhythmia, 1 case of breathing difficulties, 5 cases of incision infection and 1 case of death in the control group. Conclusion Implementation of fine nursing management is effective to shorten indwelling time of drainage tube and length of postoperative hospital stay of patients undergoing simultaneous bilateral lobectomy. (目的 探讨同期双侧肺叶切除围手术期实施精细化护理干预的效果。方法 选取2015年1月—2021年12月医院收治的行同期双侧肺叶切除患者52例, 随机分为对照组和观察组, 各26例。对照组围手术期采取常规护理, 观察组围术期采取精细化护理干预。记录和分析两组患者引流管留置时间、术后平均住院日、住院费用和术后并发症。结果 观察组患者引流管留置时间、术后平均住院日较对照组缩短, 差异有统计学意义(P＜0. 05)。观察组术后发生气胸1例, I期压疮1例, 心律失常5例, 呼吸困难2例, 切口感染2例; 对照组术后气胸1例, I期压疮3例, 心律失常5例, 呼吸困难1例, 切口感染5例, 死亡1例。结论 同期双侧肺叶切除围手术期实施精细化护理干预, 能缩短患者引流管留置时间和术后平均住院日, 对促进患者术后康复具有积极意义。

Feasibility of oxygen saturation related diffusion index for monitoring oxygenation status in patients with acute respiratory distress syndrome (应用指氧饱和度相关弥散指数监测急性呼吸窘迫综合征患者氧合状态的可行性研究)

Objective To analyze the clinical value of oxygen saturation related diffusion index for monitoring oxygen and status in patients with acute respiratory distress syndrome(ARDS). Methods The enrolled cases were 130 patients with ARDS treated in the hospital from May 2017 to January 2020. The oxygen saturation related diffusion indexes were assessed and compared between patients with mild, moderate and severe ARDS. Results Of the 130 patients with ARDS, 38 were mild, accounting for 29. 23%; 55 were moderate, accounting for 42. 31%; and 37 were severe, accounting for 28. 46%. Refers to oxygen saturation-related diffusion index, mild ARDS patients were significantly higher than moderate patients, moderate patients were significantly higher than severe patients(P＜0. 05). Conclusion Finger oxygen saturation-related diffusion index has a negative correlation with the condition of patients with ARDS. Strengthening the monitoring of finger oxygen saturation-related diffusion index is of great significance for assessing the condition, treatment effect and prognosis of ARDS patients. (目的 分析应用指氧饱和度相关弥散指数监测急性呼吸窘迫综合征(ARDS)患者氧合状态的临床价值。方法 选取医院2017年5月—2020年1月收治的130例ARDS患者为研究对象, 对比轻度、中度、重度ARDS患者指氧饱和度相关弥散指数。结果 130例ARDS患者中38(29. 23%)例轻度, 55(42. 31%)例中度, 37(28. 46%)例重度。指氧饱和度相关弥散指数: 轻度ARDS患者明显高于中度患者, 中度患者明显高于重度患者, 差异有统计学意义(P<0. 05)。结论 指氧饱和度相关弥散指数与ARDS患者的病情呈负相关性, 加强指氧饱和度相关弥散指数监测, 对于评估ARDS患者病情、治疗效果、预后等具有重要意义。

Preparation of 3D Semi-Interpenetrated Polymer Networks Polymer Electrolyte for Lithium Metal Battery

锂金属电池作为下一代高比能量电池技术受到人们越来越广泛的关注。然而由锂枝晶生长引发的安全问题是锂金属电池商业化面临的最大挑战之一。具有高锂离子迁移数和离子电导率的聚合物电解质是抑制锂枝晶生长的重要策略之一。本文将季戊四醇四丙烯酸酯和自由基引发剂AIBN添加至商业化电解液中,采用具有单离子传导功能的多孔聚合物电解质为锂金属电池的电解质隔膜,通过在电池内部发生热诱导原位聚合制备三维半互穿网络单离子传导聚合物电解质,达到提高电解质隔膜离子电导率和机械拉伸性能,以及有效抑制锂枝晶生长的目的。通过该策略的实施,成功获得了室温离子电导率0.53 mS·cm-1和锂离子迁移数0.65的良好结果。应用于锂金属电池,证明该电解质能够有效抑制锂枝晶的生长和倍率性能的提高,为锂金属电池的开发提供了良好的解决路径。As the next generation high-energy batteries, lithium metal battery has attracted more and more attention due to its highest specific capacity (3860 mA·h·g-1) and the lowest anode potential (-3.04 V versus the standard hydrogen electrode, SHE). However, the safety problem caused by lithium dendrite growth is one of the biggest challenges for the commercialization of lithium metal batteries. Single ion conducting polymer electrolytes, which deliver high lithium ion transference number, represent one of the important strategies to inhibit lithium dendrite growth. However, the poor compatibility with electrodes and low ionic conductivity largely limit their practical application. In the present work, the cross-linking pentaerythritol tetraacrylate precursor and AIBN radical initiator was select as an additive in the commercial 1 mol·L-1 LiPF6-EC/PC (v:v = 1:1) electrolyte, and then was added into the high porous single ion conducting polymer electrolyte. The as-prepared single ion conducting polymer electrolyte was used as the polymer electrolyte for assembling lithium metal battery with the LiFePO4 cathode. The three-dimensional semi-interpenetrating network inside the high porous single ion conducting polymer electrolyte was fabricated by thermal-induced in-situ polymerization inside of the battery by putting the battery in an oven at high temperature. The key properties were successfully investigated. The results indicated that the formed three-dimensional semi-interpenetrating network of the single ion conducting polymer electrolyte was great favorable to improve the ionic conductivity and mechanical property of the polymer electrolyte, and subsequently, to effectively inhibit the growth of lithium dendrite. As a result, the ionic conductivity of 0.53 mS·cm-1 at room temperature and lithium ion transference number of 0.65 were successfully obtained through the implementation of this strategy. It is proved that the as-presented electrolyte can effectively inhibit the growth of lithium dendrite and improve the rate performance, which provides a facile solution for the development of lithium metal battery technology.国家重点研发计划项目(2018YFB1502903);国家自然科学基金项目(21603197)通讯作者:张运丰E-mail:[email protected]:Yun-FengZhangE-mail:[email protected]中国地质大学（武汉）材料与化学学院,湖北 武汉 430074Sustainable Energy Laboratory, Faculty of Material Science and Chemistry, China University of Geosciences (Wuhan), Wuhan 430074, Hubei, Chin