关于“经济发展方式转变进程中的财税政策”的探讨(笔谈)

转变经济发展方式是当前中国的热门话题,而上海在城市发展中又肩负着率先转变的重要任务,在这一意义和背景下,2010年4月24日由上海金融学院学院主办、上海金融学院公共经济管理学院承办的“《中国城市财政发展报告2009/2010:促进‘两个中心’建设的上海城市财政》首发式暨‘经济发展方式转变进程中的财税政策’论坛“在我校举行。与会专家围绕经济发展方式转变进程中的财税政策的“趋势与目标“、“机遇和挑战“、“实施方略“和“地方实践“等四个专题进行研讨,各抒己见,智慧交锋。现将其真知灼见整理摘要与读者分享,以期待更多学者共同关注当前经济发展方式转变进程中的财税政策

Highly Stereoselective Synthesis of(1R,2S,3R,4S,6R)-2,3,4-Trihydroxy-cyclohexyl-β-amino Acid Derivative

多羟基环己基手性β-氨基酸及其衍生物具有重要的药物、生物和合成用途.本文对从内消旋cis-1,2,3,6-四氢邻苯二甲酸酐经去对称化得到的内酯关键中间体(2)的绝对构型进行了确定,并通过邻二羟基化和内酯开环,经两步反应以45%的产率从化合物(2)高立体选择性地合成了光学活性的(1R,2S,3R,4S,6R)-2,3,4-三羟基-2-(苄氧羰基氨基)-环己烷甲酸苄酯(6).Polyhydroxy cyclohexyl-β-amino acids and their derivatives have important pharmaceutical,biological and synthetic applications.This paper describes the determination of the absolute configuration of the key lactone intermediate(2),obtained by cinchonine mediated desymmetrization of cis-1,2,3,6-tetrahydrophthalic anhydride(1),and its application in the stereoselective synthesis of a polyhydroxy cyclohexyl-β-amino acid derivative(6).In order to determine the absolute stereochemistry of the lactone intermediate,compound(2)was treated with K2CO3 in benzyl alcohol to provide the ring opened product(3) which was converted to its C4 p-bromobenzoate(4) whose absolute stereochemistry was determined as(1S,4S,6R) by single crystal X-ray diffraction analysis therefore proved the configuration of the lactone intermediate(2).Catalytic dihydroxylation of the lactone intermediate(2) with OsO4 and NMO provided the desired dihydroxy compound(5) which underwent alcoholisms with benzyl alcohol in the presence of K2CO3,providing the target compound,(1R,2S,3R,4S,6R)-2,3,4-trihydroxy-cyclohexyl-β-amino acid derivatives(6),in 2 steps in 45% overall yield in a highly stereoselective manner,which highlighted the usefulness of the lactone intermediate(2) in the asymmetric synthesis of polyhydroxy cyclohexyl-β-amino acid derivatives.国家自然科学基金(20372056)资

A Desymmetrization Approach for the Synthesis of a Key Chiral Intermediate for Polyhydroxy Cyclohexyl β-amino Acid Derivatives

[中文文摘]多羟基环己基手性β-氨基酸及其衍生物具有重要的药物、生物和合成用途.本文报道以廉价的内消旋cis-1,2,3,6-四氢邻苯二甲酸酐为起始原料,以奎宁为手性试剂,通过去对称化、Curtius重排和醇解以及分子内立体选择性碘内酯化和消除反应等五步反应,以近40%的总产率简捷地合成光学活性多羟基环己基β-氨基酸的关键中间体.［英文文摘］Carboxycyclic polyhydroxy β-amino acids are a group of both naturally occurring and synthetic compounds with interesting biological and pharmacological activities.They have also been widely used as starting materials or intermediates for the preparation of heterocycles,natural products or their analogues and for drug development.Therefore the synthesis and biological studies of carbocyclic polyhydroxy β-amino acids have attracted increasing attention in recent years.Optical active cyclohexenyl(or dienyl)β-amirno acids are important chiral intermediates for the synthesis of cyclohexyl polyhydroxy β-amino acids.This paper describes the synthesis of a key chiral cyclohexenyl β-amino acid derivative(9) for this purpose.The synthesis of the intermediate was achieved by quinine inducde desymmetrization of cisË 1 ,2 ,3,6-tetrahydrophthalic acid to give the monoester(5) in 93% yield and > 93 %ee. One pot Curtius rearrangement followed by alcoholysis with benzyl alcohol afforder the carbamate(6) in 83% yield.Saponification of the methyl ester in(7), followed by iodo-lactonization and final elimination gave the desired cyclohexeny β-amino acid derivative(9) in 40% overall yield in 5steps.This intermediate has been converted into a few cyclohexyl polyhydroxy β-amino acids, which will be reported in due course.国家自然科学基金(0042-K16197)资

非线性双端固支梯形梁压电俘能器结构设计与特性分析

设计了一种非线性双端固支梯形梁压电俘能器,用于收集环境中的振动能量,并将振动能转换为电能,为微小型电子元器件供能。自然环境中振动源的振动频率大多在100 Hz以下,该俘能器采用引入非接触磁力的方法,降低其谐振频率、拓宽俘能频带并提高输出性能。在理论分析的基础上,建立了Matlab/Simulink仿真模型并进行试验测试,对比分析了线性及非线性双端固支梯形梁压电俘能器的谐振频率、带宽及输出性能,同时研究了输出性能在3个参数(固定磁铁与质量块磁铁间距d、外接负载电阻R、外界激励加速度a)变化时的响应。仿真与试验结果表明,引入的非接触磁力使压电俘能器谐振频率降低了9 Hz,俘能带宽拓宽了20%,输出功率提高了7. 5%

微山湖发现中国淡水蛏

2010年10月23日在山东省微山县韩庄附近的微山湖京杭运河入湖口航道采集到淡水蛏标本32个,经鉴定为中国淡水蛏(Novaculina chinensis),微山湖为该种在我国的最北分布,表明其分布区已延伸至古北界

A representation of the configurations and evolution of metamorphic mechanisms

Metamorphic mechanisms are members of the class of mechanisms that are able to change their configurations sequentially to meet different requirements. The paper introduces a comprehensive symbolic matrix representation for characterizing the topology of one of these mechanisms in a single configuration using general information concerning links and joints. Furthermore, a matrix representation of an original metamorphic mechanism that has the ability to evolve is proposed by uniting the matrices representing all of the mechanism&#39;s possible configurations. The representation of metamorphic kinematic joints is developed in accordance with the variation laws of these mechanisms. By introducing the joint variation matrices derived from generalized operations on the related symbolic adjacency matrices, evolutionary relationships between mechanisms in adjacent configurations and the original metmaorphic mechanism are made distinctly. Examples are provided to demonstrate the validation of the method.</p

A representation of the configurations and evolution of metamorphic mechanisms

Metamorphic mechanisms are members of the class of mechanisms that are able to change their configurations sequentially to meet different requirements. The paper introduces a comprehensive symbolic matrix representation for characterizing the topology of one of these mechanisms in a single configuration using general information concerning links and joints. Furthermore, a matrix representation of an original metamorphic mechanism that has the ability to evolve is proposed by uniting the matrices representing all of the mechanism&#39;s possible configurations. The representation of metamorphic kinematic joints is developed in accordance with the variation laws of these mechanisms. By introducing the joint variation matrices derived from generalized operations on the related symbolic adjacency matrices, evolutionary relationships between mechanisms in adjacent configurations and the original metmaorphic mechanism are made distinctly. Examples are provided to demonstrate the validation of the method.</p

奇奇核~(174)Re的转动带(英文)

利用重离子熔合蒸发反应~ (１５９)Ｔｂ（~(２０)Ｎｅ，５ｎ）~(１７４)Ｒｅ，并通过激发函数、ＫＸ－ γ和γ－γ符合测量，研究了~(１７４)Ｒｅ核的高自旋态．鉴别并指定了~(１７４)Ｒｅ核的一个 基于л１／２－［５４１］ｖ１／２~ -［５２１］准粒子组态上的双退耦带．还发现了两个分别具 有半退耦特征和强耦合特征的转动带，定性地讨论了它们的粒子组态