青橄榄利咽含片的大鼠长期毒性研究

青橄榄利咽含片的大鼠长期毒性研究廖绵初，干侣仙（厦门大学抗癌研究中心361005）青橄榄利咽含片以青橄榄为主，辅以麦冬、薄荷脑、生地、西洋参等。我们在1995年3-4月进行大鼠的长期毒试验。Sd大鼠72只购自上海西普尔·必凯公司，体重100±10g，..

HEPATITIS E VIRUS INFECTION IN THE PATIENTS WITH LIVER CANCER AND CIRRHOSIS

目的研究肝癌和肝硬变患者的肝炎病毒感染情况。方法用酶联免疫吸附测定（ElISA）法测定患者血清中的乙型肝炎病毒表面抗原（HbSAg）、丙型肝炎病毒抗体（抗HCV）和戊型肝炎病毒抗体（抗HEV）。结果肝癌患者中抗HEV阳性率为58.9%（63/107），HbSAg阳性率为69.2%（74/107），抗HCV阳性率为10.3%（11/107），肝硬变患者的阳性率依次为63.0%（17/27）、74.1%（20/27）、7.4%（2/27）。只有抗HEV阳性而HbSAg和抗HCV阴性的肝癌患者有13例（12.2%）。仅HbSAg阳性而抗HEV和抗HCV阴性的有24例（22.4%），仅抗HCV阳性而抗HEV和HbSAg阴性的有3例（2.8%）。全部阴性的有10例（9.4%）。肝硬变患者中仅抗HEV阳性而抗HCV和HbSAg阴性的有5例（18.5%），仅HbSAg阳性而抗HEV和抗HCV阴性的有9例（33.3%），全部阴性的有1例（3.7%）。结论除HbV和HCV外，HEV感染似乎在肝癌变及肝硬变中也起着一定的作用URPOSE Study on hepatitis virus inFection in patients with liver cancer and cirrhosis.METHODS ELISA was applied to determine HBV,HCV and HEV serial markers of the patientsRESULTS The positive rate of antiHEV is 589%(63/107),the positive rate of HBsAg is 692% (74/107),the positive rate of antiHCV is 103% (11/107) in the patients with liver cancer.The positive rates of the patients with cirrhosis were 630%( (17/27),741% (20/27),74%(2/27),respectively.Among the patients with liver cancer,13 cases (122%) had positive antiHEV only,with negative of HBsAg and antiHCV,24 cases (224%) had positive HBsAg only with negative antiHCV and antiHEV3 cases(2.8%) had postive antiHCV only with negative of HBsAg and antiHEV.10 cases (94%) had all negative antiHEV,HBsAg,and antiHCV.Among the cirrhosis,5 cases (185%) had positive antiHEV,only with negative HBsAg and antiHCV.9 cases (333%) had positive HBsAg, only with negative of antiHEV and antiHCV.1 case (3.9%) were all negative.CONCLUSION Apart From HBV and HCV,HEV seems act both on liver cirrhosis and liver cancer.福建省卫生厅基

厦门某工业区饮用水有机污染调查及治理的初步研究

厦门某工业区饮用水有机污染调查及治理的初步研究干侣仙，廖绵初，郑金树，高振华（厦门大学抗癌研究中心厦门361005国家海洋局第三海洋研究所，厦门市卫生防疫站）厦门市某重要工业区，面积约为厦门岛区面积的1/6，却集中了厦门市规模较大、污染严重的如合成氨..

厦门饮用水有机污染物危害的研究

厦门饮用水有机污染物危害的研究厦门市卫生防疫站高振华，梁荣春国家海洋局第三研究所郑金树厦门大学抗癌研究中心于侣仙，廖绵初许多研究表明，城市饮用水中存在着致突变的有机物，它们来源于水源水的污染、饮水氯化消毒的副产物三卤甲烷（THM3）等。因此，近年来饮..

蚕豆根尖微核技术在饮用水致突变性研究中的应用

采用蚕豆根尖微核（Mn）监测技术，对饮用水有机污染物的诱变性进行了研究。结果表明：饮用水诱变性强度，枯水期＞平水期＞丰水期。采用混凝沉淀工艺，出厂水Mn比进厂水降低40.6%。用气浮法制水工艺的出厂水Mn在正常范围内

我国厦门地区散发性戊型肝炎病毒部分核苷酸序列分析

自新疆发生戊型肝炎（HE）暴发流行以来，已陆续报道我国其他地区存在散发感染〔1〕。本实验室已报道我国广州地区的散发性HEV与我国北方和国外HEV在基因结构上有明显不同〔2，3〕。最近又对从厦门地区急性HE病人的血清中检出的HEVrnA作序列分析，结果...总后指令性课

The EFFect of Lotus Seed on AFlatoxin B_1 induced SCE and CGC in Cultured Human Peripheral Lymphocyte

莲子对黄曲霉毒素（b_1）诱发的人体淋巴细胞姐妹染色单体互换和细胞周期状态的影响干侣仙，廖绵初，黄少珍（厦门大学抗癌研究中心，广西壮族自治区肿瘤研究所）肿瘤细胞遗传学和肿瘤形成过程的研究已表明［1］在细胞恶性转化和肿瘤形成的多阶段过程中，存在着突变，...The eFFect on sister chromatid exchange(SCE) and cell generation circle(CGC) of human peripheral lymphocytes induced by AFB1 was detected using extracts of Lotus seed cotyledon and lotus plumule.It was discovered that the Frequencies of SCE of ethanol extracts of lotus seed cotyledon were lower and the Frequencies of SCE of physiological saline extracts of lotus plumule were higher than ethanol extracts.the level of M3 of CGC and the proliFeration rate index(PRI) of lotus seed cotyledon ethanol extracts were near to those of the normal control,and the level of those lotus plumule extracts of ethanol and physiological saline were dropped signiFicantly.The results show that lotus seed cotyledon has the capacity of decrease damage of chromatid by AFB1 and increase the rate of cell generation cycle

HEV InFection in Patien with PHC or Hepatocirrhosis

肝癌、肝硬化病人的戊肝感染状况廖绵初，干侣仙，尹本康（厦门大学抗癌研究中心）（广东粤北第二人民医院）戊型肝炎是经肠道传播的病毒性疾病，其特点是暴发性流行和散发性流行。感染者多为青、壮年，发病急，死亡率高，尤其对孕妇危害更大￣［1］.我国除新疆等少数地...patients with PHC or Hepatocirrhosis were detected by HEV ELISA It wasdiscovered that 10(50%)patients were positive For IgG anti-HEV and 7(35%)were also positive ForIgM anti-HEV, only 1 patient was positive For IgM anti-HEV, 8 potients of these were positive ForHBsAg, anti-HBe and anti-HBc.All patients had at least HBV maker and 3(15%)were positive Foranti- HCV.No positive For IgM anti-HAV and IgG anti-HDV

Relationship between the concentration of CHCl_3, CCl_4 and the ratio of micronucleus in an urban drinking water and its source water

为了解并改善饮用水质，在1991年第4季度至1993年第1季度，于某市水源水和水厂出厂水中采水样，每季度采集1次，每站位同时取两份，一份测定卤代烃的含量，一份用于处理蚕豆根尖并计数根尖细胞微核率。结果表明水厂出厂水中卤代烃含量比水源水的高，尤其是四氯化碳，各水厂出厂水中卤代烃的含量也有明显差异。发现水源水、水厂出厂水中四氯化碳含量与致突变有明显的相关性。ource water and outFlow of waterworks were sampled every quarter From the Fourth quarter 1991 to the First quarter 1993.Two samples were taken From each station, one For determination of CHCI_3, and CCI_4, and the other For treating of VICIA FADA root tip cell and counting the ratio of micronucleus of the root.It showed that the concentration of CHCI_3 and CCl_4 were higher in waterworks than in source water,especially For CCl_4.DiFFerences of chloro-carbons concentration were Found among waterworks.SigniFicant relationship was demonstrated between the concentration of CCl_4, and the mutagenesis