广东省高等院校名牌专业评价方案的设计原则与思路

专业是高校实现其职能的基本单位。名牌专业评价对专业的改革、建设与发展,以及教育教学质量的提高具有重要意义。通过对名牌专业评价的目标与作用的分析,探讨构建专业评价指标体系的原则、标准、思路和应注意的问题,以期为名牌专业的评价提供指导。“广东省新世纪高等教育教学改革工程”项目“广东省普通高等学校名牌专业评价的研究与实践”(粤教高[2001]106号)的研究成果之

基于认知脑区的脑-机接口技术及其在康复中的应用研究进展

脑-机接口(BCI)技术通过解码大脑信号可实现人类和外部设备的交互,近年来取得了一些重要的突破,但其应用推广目前还存在许多障碍。当前常见的BCI控制信号一般来源于与感觉运动相关的脑区,这些信号仅能反映肢体运动意图的有限部分。因此,需要探索更多可用于控制BCI系统的脑信号源。基于认知脑区的脑信号具有更加直观、有效的特点,可作为拓展脑BCI信号源的新途径。本文综述了基于单一脑区和多脑区混合的认知BCI的研究现状,并归纳了其在康复医学领域的应用研究,以期将基于认知的BCI技术作为未来BCI康复应用的突破口

基于认知脑区的脑-机接口技术及其在康复中的应用研究进展

脑-机接口(BCI)技术通过解码大脑信号可实现人类和外部设备的交互,近年来取得了一些重要的突破,但其应用推广目前还存在许多障碍。当前常见的BCI控制信号一般来源于与感觉运动相关的脑区,这些信号仅能反映肢体运动意图的有限部分。因此,需要探索更多可用于控制BCI系统的脑信号源。基于认知脑区的脑信号具有更加直观、有效的特点,可作为拓展脑BCI信号源的新途径。本文综述了基于单一脑区和多脑区混合的认知BCI的研究现状,并归纳了其在康复医学领域的应用研究,以期将基于认知的BCI技术作为未来BCI康复应用的突破口

脑卒中患者上肢康复脑功能及其康复治疗技术

脑卒中患者的上肢运动功能障碍发生率高,恢复较难,严重影响患者的独立生活能力和生活质量。本文概括了脑卒中患者的上肢康复脑功能理论,并从中枢神经干预治疗和外周神经干预治疗两个方面介绍了现有的脑卒中上肢运动功能康复技术。文献查阅结果表明各类康复治疗手段具有不同的针对性和局限性,早期、科学和合理的综合康复训练才能最大程度地帮助脑卒中患者实现上肢运动功能的完全康复,回归正常生活

Effects of Sintering Additives on the Liquid-phase Sintering of SiC

研究了以Al2O3、Y2O3、Al2O3-Y2O3、SiO2-YAG为烧结助剂时,SiC液相烧结行为以及烧结过程中发生的主要物理化学变化.与传统固相烧结相比,液相烧结使SiC陶瓷性能显著提高.通过对烧结体失重率、线收缩率及密度的测量和断面形貌的观察发现:Al2O3对坯体致密化的促进效果较差;Y2O3为助剂烧结时,由于高温下剧烈挥发,不能有效促进致密化;不同配比的Al2O3-Y2O3助剂能有效促进坯体致密,当配比满足形成YAG的化学计量比要求时,最有利于SiC的烧结.同时对SiC的液相烧结机理也进行了探索.Silicon carbide ceramics have been widely used in petroleum chemical,automotive,mechanical and aerospace industries because of their excellent resistance to thermal shock,high temperatures,oxidation and chemical corrosion.In this paper liquid phase sintered silicon carbide ceramics were prepared with A_2O_3、Y_2O_3、A_2O_3-Y_2O_3 and SiO_2-YAG as sintering additives respectively.Compared with solid state sintered silicon carbide ceramics,the liquid phase sintered one exhibits superior performance.The effects of different additives on the densification and microstructure were also investigated by the measurement of weight loss,linear shrinkage and relative density as well as X-ray diffraction(XRD) and scanning electron microscopy(SEM) analysis.It is found that A_2O_3 was not effective sintering additive due to its high evaporation rate at the sintering temperature.With Y_2O_3 as the sintering additive,large amount of Y_2O_3 from the powder bed diffused into the sample,but the materials did not densify,so Y_2O_3 could not improved the densification of silicon carbide effectively.However,different ratios of A_2O_3-Y_2O_3 significantly promote the sintering,and much improved densification were obtained.With the best result for A_2O_3-Y_2O_3 ratio right for the formation of YAG,the final density was 3.03 g/cm~3,and SEM showed the densification of this sample was highest.The liquid-phase sintering mechanisms of SiC were also studied.国家自然科学基金(50472056);; 福建省重大科技专项(200314007);; 国家“863”计划(2002AA305101)资

Protonization of Amino Functional Groups Confined in Nanochannels

质子化过程是大多数酸碱理论的核心，也发生在许多生命过程中。因此，研究限域环境中分子或官能团的质子化过程将为进一步认识酸碱理论和阐述限域环境中生物分子的基本行为提供理论依据。本文提出了一种以荷电电化学探针检测多孔氧化铝阵列纳米通道内表面官能团质子化过程的新方法。该方法利用纳米通道表面官能团的质子化过程改变了表面荷电性质，从而调控荷电电化学探针在纳米通道中的传输行为。实验中以喷涂在阵列氧化铝纳米通道膜一侧的薄金膜为工作电极，检测通过阵列纳米通道荷电电化学探针的流量，以此获得纳米通道限域条件下的质子化过程。同时以多孔氧化铝阵列纳米通道为限域空腔，利用硅烷化反应将氨基修饰在纳米通道的内表面，通过检测不同pH值条件下铁氰酸根离子在纳米通道中流量的变化，获得了纳米通道限域条件下氨基质子化滴定曲线。结果表明，纳米通道限域条件下氨基官能团发生一步质子化，其pK1/2值为5.9。本文提出的方法适用于研究纳米通道限域条件下其它官能团或生物分子的质子化过程。Protonization process is the key step of acid-base reaction and occurs in many biological processes. Study of the protonization process of molecules and/or functional groups in confined conditions would assist understanding in the acid-base theory and confinement effect of biomolecules. In this paper, we developed a novel approach to study protonization of functional groups in porous anodic alumina array nanochannels by measuring the flux of electrochemical active probes using an Au film electrochemical detector sputtered at the end of the nanochannels. The protonization status of the surface functional groups in nanochannels can change the surface charges and further modulate the transportation of charged electroactive probes through nanochannels. The titration curve for the protoniation of amine groups in nanochannel confined condition is obtained by measuring the current signal of ferricyanide probe flowing through an anime-anchored PAA nanochannel array at different solution pH. Results show that the protonization of amino group in nanochannel occurs in one step with a pK1/2=5.9. The present method provides an effective tool to study the protonization processes of various functional groups and biomoelcuels.973项目（No. 2012CB933804），国家自然科学基金项目（No. 21035002），高等学校博士点基金（No. 200802840012）和江苏省自然科学基金攀登计划（No. BK2010009）资助作者联系地址：南京大学化学化工学院，生命分析化学国家重点实验室，南京 210093Author's Address: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China通讯作者E-mail：[email protected]