Visual acuity and intraocular pressure values in patients with phacomorphic glaucoma following phacoemulsification and intraocular lens implantation

Objectives: To evaluate the efficiency of phacoemulsificationand uncomplicated Intraocular Lens (IOL) implantationsurgery on visual prognosis and intraocular pressurecontrol on eyes with phacomorphic glaucoma.Materials and methods: Totally 17 eyes of 17 patientswith phacomorphic glaucoma who underwent cataractsurgery was evaluated retrospectively. Intraocular pressure(IOP), best corrected visual acuity, axial length, thicknessof the lens and anterior chamber depth of the caseswere measured preoperatively and postoperatively.Results: Ten cases (59 %) were male and 7 (41%) werefemale. The mean age of the cases was 63.8 ± 10.3 years(40-83). The average follow up period was 12.1 ± 6.7months (3-26). Preoperative average intraocular pressurewas 44.7 ± 10.02 mm Hg (30-70), and the average IOPin the last postoperative follow up was 12.8 ± 1.9 mm Hg(10-16). There was no IOP increase in any eye during followup. Decrease in IOP in the first postoperative day wasstatistically significant (p<0.001). Preoperative averageaxial length was 22.1 ± 0.7 mm (21.0 - 24.2) and averagelens thickness was 5.5 ± 0.2 mm (5.1 - 5.9). Preoperativeand postoperative average anterior chamber depthwere 1.5 ± 0.3 mm (0.9 - 2.1) and 2.6 ± 0.1 mm (2.4 - 2.9)(p<0.001). Significantly increases in visual acuity weredetermined postoperatively in 14 (82%) cases.Conclusion: It was concluded that in cases with phacomorphicglaucoma, uncomplicated phacoemulsificationand IOL implantation is safe and effective procedure inimproving visual acuity and controlling IOP

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion

Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P &gt; 0.05). However, differences in platelet values were statistically significant (P &lt; 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R.Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P &gt; 0.05). However, differences in platelet values were statistically significant (P &lt; 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R

Ocular Problems in Triple-A Syndrome and Their Management

Triple-A syndrome (Allgrove syndrome), is a rare autosomal recessive syndrome that is characterized by adrenal insufficiency, alacrimia and achalasia. In this report, we present a case of triple-A syndrome and discuss the ocular manifestations of the diseases along with evaluation of the therapeutic options. In addition to the classic triad of triple-A syndrome, our patient had intermittent exotropia. The patient was receiving oral steroids for adrenal insufficiency and artificial tear drops for eye dryness. Surgery was planned for exotropia. Punctum plug insertion was made simultaneously with bilateral lateral rectus recessions. Postoperative follow-up revealed near and distant horizontal deviation at the interval of ±10 PD. The patient’s complaints about eyes regressed significantly as well. Triple-A syndrome is a life threatening and rare disorder that could be fatal when undiagnosed. Punctum plugs are convenient therapy option for the treatment of xerophthalmia encountered in triple-A syndrome. With strabismus surgery including punctum plug insertion, any other surgery can be simultaneously carried out during a single session of general anesthesia. (Turk J Ophthalmol 2012; 42: 492-4

A new surgical treatment option for chronic total oculomotor nerve palsy: a modified technique for medial transposition of split lateral rectus muscle

WOS: 000386656800006PubMed: 27224949Purpose: To describe a new surgical modified procedure in patients with chronic total oculomotor nerve palsy and to evaluate the results of this procedure. Methods: Eight eyes of 6 consecutive patients who underwent strabismus surgery due to chronic total oculomotor nerve palsy were enrolled in the study. the lateral rectus muscle was split into two halves and disinserted from the sclera. the upper half of the muscle was passed under the superior rectus muscle and the inferior half of the muscle was passed under the inferior rectus muscle. the two halves of the muscle were moved to the medial rectus muscle insertion area and were sutured to sclera near the insertion. Additional medial rectus resections were made in the undercorrected patients. Results: the mean age was 21.8 +/- 12.1 years (range: 11 to 42 years). Postoperatively, 4 of 6 patients had stable horizontal deviations; 1 had orthophoria, 2 had 10 prism diopters (PD) of exotropia, and 1 had 10 PD of esotropia. However, 2 cases had 25 and 30 PD of undercorrection. Additional medial rectus resections were made in these undercorrected patients and horizontal deviations reduced to 15 and 20 PD of exotropia, respectively. the mean primary position horizontal deviation, which was 74.1 +/- 10.2 PD before the surgeries, reduced to 10.8 +/- 6.6 PD after the surgeries (P < .001). Conclusions: the authors described a new and relatively simple modified surgical procedure for the treatment of chronic total ocular nerve palsy and reached satisfactory outcomes. Further studies with larger sample sizes are warranted

Clinical characteristics and surgical outcomes of pediatric rhegmatogenous retinal detachment

WOS: 000379324900010PubMed: 26627689The objective of this study was to analyze the characteristics and surgical results of pediatric rhegmatogenous retinal detachment (RRD). the medical records of 30 eyes of 29 patients younger than 18 years of age who underwent vitreoretinal surgery due to RRD were analyzed. the gender, age, laterality, duration of presenting symptom, etiology, ocular and systemic co-morbidities, type of breaks, lens status, presence of proliferative vitreoretinopathy (PVR) and its grade, initial and final best-corrected visual acuities (BCVAs), surgical management, number of operations, duration of follow-up, functional and anatomical success, and complications were noted. As the most common predisposing factors were trauma (trauma group) and myopia (myopia group), the data of these patients were further analyzed. the mean age was 12.6 +/- A 3.0 years. There were 23 male (79.3 %) and 6 female (20.6 %) subjects. the most common etiologic factors were high myopia (40 %) and trauma (36.6 %). Functional success rate was 70 % (n = 21) after the primary surgeries and was 80 % (n = 24) after the secondary surgeries. There were no significant differences between the trauma and myopia groups regarding the presence of total retinal detachment, macula-off status, and the rate of PVR worse than grade C. Although the preoperative mean BCVA and the initial and final retinal reattachment rates of the groups were statistically similar, trauma group had significantly higher postoperative mean BCVA compared to myopia group (p = 0.013). Myopia and trauma were the most common etiologic factors for RRD in children. the visual outcomes of trauma-associated RRD were better than those of myopia-associated RRD

Künt Göz Travmalı Adli Olgularda Santral Korneal Kalınlık Ölçümlerinin Değeri

Bu çalışmada, künt göz travması nedeniyle başvuran olguların ultrasonik pakimetri ile santral kornea kaimlik değişimleri değerlendirilerek adli raporlandırma sürecinin belirlenmesi amaçlandı. Gaziantep Üniversitesi Tıp Fakültesi Adli Tıp Anabilim Dalı’nda, 2004-2007 tarihleri arasında savcdık kanalıyla gönderilen vakalardan künt göz travmalı 76 olgunun, göz muayenelerine ek olarak ultrasonografik pakimetriyle santral korneal kalınlık (SKK) değerleri ölçüldü. Olgular travmanın oluş zamanı ile muayene zamanı arasında geçen süre dikkate alınarak iki gruba ayrıldı. Birinci grup travma ile travmadan en fazla 3 ay geçen olguları, ikinci grup ise 3 aydan sonra muayeneye gelen olguları kapsamaktaydı. Tüm olguların sağlam gözleri de kontrol grubu alınarak irdelendi. Olguların cinsiyet, yaş, travma nedeni gibi tanımlayıcı istatistiklerin yanı sıra, değişkenler için ortalama ve standart sapma hesaplandı. Hesaplamalar ve testler SPSS 13.0 programı kullanılarak yapıldı. Oluşturulan gruplarm sağlam ve travmalı gözlerinin SKK değerleri ortalamalarımn önemli derecede farklılık gösterip göstermediğinin belirlenmesi maksadıyla t testi uygulandı. P değeri < 0.05 olan değerler istatistiksel olarak anlamlı kabul edildi. Çalışma kapsamına alman 76 olgunun 47’si erkek, 29’u kadın olup yaş ortalaması 34.8 (16-56 yıl) idi. Travmaların %59.2’si darp, %18.4’ü trafik kazası ile, %13.2’si iş kazası ve %9.2’si çarpma-düşme nedeniyle meydana gelmişti. 30 olgudan oluşan grup I’de travmaya maruz kalmayan gözlerin ortalama SKK değeri 545.2 + 10.18 /t iken, travmaya maruz kalan gözlerin ortalama SKK değeri 565.9 + 22.4 jıt (p0.05) olarak saptandı. Künt göz travmalı adli olgularda, özellikle ilk üç ayda başvuran grup I’deki travmalı gözlerin SKK değerleri, sağlam gözle-rinkilerden daha yüksek olarak tespit edildi. Duyu veya organların işlevlerinin zayıflaması veya yitirilmesi yönünden değerlendirilen bu olgularda, adli raporlandırmanın iyileşme süreci sonrasında yapılması gerektiği için, travmadan en az 3 ay sonra muayene edilmesinin daha uygun olacağı kanısına varıldı. Anahtar kelimeler: Künt göz travması, ultrasonografik pakimetri, santral korneal kalınlı

Nasolacrimal duct intubation in the treatment of congenital nasolacrimal duct obstruction in older children

WOS: 000367856000013PubMed: 26449195Purpose the purpose of this study was to investigate the outcomes of nasolacrimal duct intubation in the primary treatment of congenital nasolacrimal duct obstruction (CNLDO) in children aged 7 years and older. Methods Thirty children aged >= 7 years who underwent primary unilateral nasolacrimal duct intubation because of CNLDO were enrolled in this study. CNLDO diagnosis was based on signs and symptoms including typical epiphora, increased tear meniscus, recurrent or persistent mucopurulent discharge, and an abnormal dye disappearance test (DDT). Surgical success was defined as complete resolution of previous signs and symptoms and DDT grade 0-1. Results the mean age was 10.7 +/- 2.5 years (ranging from 7 to 15 years). of the 30 patients, 18 were male and 12 were female. the mean follow-up period was 8.8 +/- 3.4 months (ranging from 6 to 16 months). the mean silicone tube removal time was 4.6 +/- 1.1 months (ranging from 3 to 6 months). the complete resolution of signs and symptoms with DDT grade 0-1 was observed in 22 of 30 cases (73.3%) during the follow-up period. the mean age of the patients with unsuccessful outcomes was 12.7 +/- 1.4 years, whereas that of the patients with successful outcomes was 10.0 +/- 2.4 years, and the difference was statistically significant (P = 0.006). No serious intra-and/or postoperative complication was observed. Conclusions the current study demonstrates that nasolacrimal duct silicone intubation with intranasal endoscopic visualization has favorable outcomes as a primary treatment of persistent CNLDO in children aged 7 years and older. It can be used to reduce the need for dacryocystorhinostomy which is a more invasive procedure

Association between penetrating eye injuries and attention deficit hyperactivity disorder in children

GOKCEN, CEM/0000-0003-3824-5890WOS: 000358297200019PubMed: 25680617Purpose To investigate whether there is an association between penetrating eye injuries and attention deficit hyperactivity disorder (ADHD) symptoms in children. Methods 45 children aged 3-18 years who were treated due to penetrating ocular injuries (patient group) and 75 control subjects (control group) were enrolled in the study. the symptoms of ADHD were evaluated by the Turkish adapted and validated form of the Conner Parent Rating Scale (CPRS). Results the mean age was 8.9 +/- 4.1 years in the patient group and 9.7 +/- 3.7 years in the control group. All subscale scores of CPRS were higher in the patient group compared with the control group (all p < 0.05). Gender-specific analyses showed that the boys of the patient group had significantly higher mean scores of all subscales, including inattentiveness, hyperactivity, oppositional defiant disorder and conduct disorder, compared with the boys of the control group (all p < 0.05). However, the girls of the patient group had higher mean scores of only the conduct disorder subscale (p < 0.05) compared with the girls of the control group. Three of 45 patients (6.6%) and 0 of 75 control subjects (0%) had a history of previous ocular trauma (p < 0.05). Conclusions There was an association between penetrating eye injuries and inattentiveness, hyperactivity, oppositional defiant disorder and conduct disorder in boys, and conduct disorder in girls. An appropriate evaluation of ADHD symptoms may prevent vision loss due to penetrating eye injuries in children. in addition, evaluation by a child psychiatrist of children presenting with penetrating eye injuries may prevent repetition of injuries