9 research outputs found
Neuro-acanthocytosis: Report of two case
Nöroakantostoz, yanlış biçimli eritrositler ve nöronal çoklu sistem patolojisi ile karakterize nadir görülen bir grup hastalık için kullanılan şemsiye bir terimdir. Klinik özellikleri koreik hareket bozuklukları, psikiyatrik bulgular ve bilişsel gerilemeye ek olarak myopati, aksonal nöropati ve nöbetleri içerir. Burada Türkiye’den, nöroakantozun farklı klinik seyirleri ile prezente olan iki olgu -42 yaşında bir kadın ve 28 yaşında bir erkek- sunulmuştur.Neuro-acanthocytosis (NA), an umbrella term for a group of rare diseases characterized by misshapen erythrocytes (acanthocytes) and neuronal multisystem pathology. Clinical features include choreatic movement disorder, psychiatric manifestations and cognitive decline, and additional features including myopathy, axonal neuropathy and seizures. Herein we report two cases - a 42-year-old woman and a 28-year-old man - from Turkey presented with heterogenous courses of neuro-acanthocytosis
Stiff Person Sendromu-Seyrek Saptanan Antikor: Olgu Sunumu
Stiff Person syndrome (SPS) is a rare, disabling syndrome characterized by progressive muscle stiffness and axial rigidity. It may have an autoimmune, paraneoplastic or cryptogenic etiology. A 59-year-old woman presented with stiffness and involuntary spasms in the lower extremities. in a neurologic examination, lower extremity and axial rigidity were revealed. Anti-glutamic acid decarboxylase antibody was negative, anti-amphiphysin was antibody positive. She was diagnosed as having SPS. the symptoms were improved after intravenous immunoglobulin and cancer therapy.Stiff Person sendromu (SPS), kaslarda ilerleyici katılık ve aksiyel kaslarda rijidite ile karakterize; nadir görüleni özürlülük oluşturabilen bir sendromdur. Otoimmün, paraneoplastik veya kritojenik etiyolojiye sahip olabilir. Elli dokuz yaşında kadın hasta bacaklarında katılık ve istemsiz spazmlar ile başvurdu. Nörolojik muayenede bacaklarda ve aksiyel kaslarda rijite saptandı. Anti-glutamik asit dekarboksilaz antikoru negatif, anti-amfifizin antikoru pozitifti. SPS tanısı kondu. İntravenöz immünoglobulin ve kanser tedavisinin ardından hastanın bulgularında düzelme izlendi
Association between recurrence of stroke and peripheral artery disease after first-ever stroke
[No abstract available
Comparison of clinical features in patients with vestibular migraine and migraine
Vestibular migraine (VM) is accepted as the most common cause of spontaneous episodic vertigo. In most patients, vestibular symptoms follow migraine headaches that begin earlier in life. The aim of this multicenter retrospective study was to find out the differences between migraine patients without any vestibular symptoms (MwoV) and VM patients and to delineate the specific clinical features associated with VM. MwoV and VM patients were compared regarding demographic features, migraine headache years, headache attack frequency, intensity, symptoms associated with headache and vertigo attacks, presence of menopause, history of motion sickness and family history of migraine. Four-hundred and forty patients with MwoV and 408 patients with VM were included in the study. Migraine with aura was more frequent in patients with MwoV (p = 0.035). Migraine headache years was longer (p 0.001) and headache intensity was higher in patients with VM (p = 0.020). Aural fullness/tinnitus was more common in patients with VM (p 0.001) when all other associated symptoms were more frequent in patients with MwoV (p 0.001) as well as attack triggers (p 0.05). Presence of menopause and motion sickness history was reported more frequently by VM patients (p 0.001). Logistic regression analysis indicated that longstanding history of migraine with severe headache attacks, aural fullness/tinnitus accompanying attacks, presence of menopause, previous motion sickness history were the differentiating clinical features of patients with VM
Comparison of clinical features in patients with vestibular migraine and migraine
Vestibular migraine (VM) is accepted as the most common cause of spontaneous episodic vertigo. In most patients, vestibular symptoms follow migraine headaches that begin earlier in life. The aim of this multicenter retrospective study was to find out the differences between migraine patients without any vestibular symptoms (MwoV) and VM patients and to delineate the specific clinical features associated with VM. MwoV and VM patients were compared regarding demographic features, migraine headache years, headache attack frequency, intensity, symptoms associated with headache and vertigo attacks, presence of menopause, history of motion sickness and family history of migraine. Four-hundred and forty patients with MwoV and 408 patients with VM were included in the study. Migraine with aura was more frequent in patients with MwoV (p = 0.035). Migraine headache years was longer (p < 0.001) and headache intensity was higher in patients with VM (p = 0.020). Aural fullness/tinnitus was more common in patients with VM (p < 0.001) when all other associated symptoms were more frequent in patients with MwoV (p < 0.001) as well as attack triggers (p < 0.05). Presence of menopause and motion sickness history was reported more frequently by VM patients (p < 0.001). Logistic regression analysis indicated that longstanding history of migraine with severe headache attacks, aural fullness/tinnitus accompanying attacks, presence of menopause, previous motion sickness history were the differentiating clinical features of patients with VM
Can vestibular migraine development be predicted in patients with new onset migraine headaches?
Objective: This study aims to determine the clinical features associated with the development of vestibular migraine (VM) in patients with migraine headaches. Methods: A cross-sectional, multicenter study was performed in nine tertiary neurology clinics. Patients with migraine without vestibular symptoms were classified as having migraine only (MO) and compared with patients with VM to determine any differences in clinical features, associated disorders, past medical history, and family history of migraine headaches. Moreover, we investigated the features that might predict the development of VM. Results: Two hundred forty-four patients with MO and 461 patients with VM were included. The age of onset of headache attacks was later in life for patients with VM (p<0.001). Migraine without aura (MwoA) was significantly more common than migraine with aura (MwA) in patients with VM (p=0.016). All associated features of migraine headaches were significantly more frequent in patients with MO than patients with VM (p<0.005). The same was true for all triggers, including fasting, sleep disturbances, menstruation, stress, flickering lights, and smartphones/computer games (p<0.005). A family history of migraine headaches was more common in MO patients (p=0.002). However, a previous history of motion sickness was significantly more common in patients with VM (p<0.001), as was aural fullness/tinnitus accompanying attacks (p<0.001). Logistic regression analysis indicated that aural fullness/tinnitus accompanying attacks and a previous history of motion sickness were risk factors for the development of VM. Conclusion: Patients with migraine reporting aural symptoms accompanying attacks and motion sickness in their past medical history are at increased risk of vestibular attacks fulfilling the diagnosis of VM later in life