ClpXP-regulated Proteins Suppress Requirement for RecA in Dam Mutants of Escherichia coli K-12

Double strand breaks (DSB) are a common source of DNA damage in both prokaryotes and eukaryotes. If they are not repaired or are repaired incorrectly, they can lead to cell death (bacteria) or cancer (humans). In Escherichia coli, repair of DSB are typically accomplished via homologous recombination and mediated by RecA. This repair pathway, among others, is associated with activation of the SOS response. DNA adenine methyltransferase (dam) mutants have an increased number of DSB and, therefore, are notorious for being RecA-dependent for viability. Here, we show that the synthetic lethality of Δdam/ΔrecA is suppressed when clpP is removed, suggesting that there is a protein, normally degraded by ClpXP, which is preventing DSB from occurring

Curriculum Guided Domain Adaptation in the Dark

Addressing the rising concerns of privacy and security, domain adaptation in the dark aims to adapt a black-box source trained model to an unlabeled target domain without access to any source data or source model parameters. The need for domain adaptation of black-box predictors becomes even more pronounced to protect intellectual property as deep learning based solutions are becoming increasingly commercialized. Current methods distill noisy predictions on the target data obtained from the source model to the target model, and/or separate clean/noisy target samples before adapting using traditional noisy label learning algorithms. However, these methods do not utilize the easy-to-hard learning nature of the clean/noisy data splits. Also, none of the existing methods are end-to-end, and require a separate fine-tuning stage and an initial warmup stage. In this work, we present Curriculum Adaptation for Black-Box (CABB) which provides a curriculum guided adaptation approach to gradually train the target model, first on target data with high confidence (clean) labels, and later on target data with noisy labels. CABB utilizes Jensen-Shannon divergence as a better criterion for clean-noisy sample separation, compared to the traditional criterion of cross entropy loss. Our method utilizes co-training of a dual-branch network to suppress error accumulation resulting from confirmation bias. The proposed approach is end-to-end trainable and does not require any extra finetuning stage, unlike existing methods. Empirical results on standard domain adaptation datasets show that CABB outperforms existing state-of-the-art black-box DA models and is comparable to white-box domain adaptation models

Blur Identification Based on Higher Order Spectral Nulls

The identification of the point spread function (PSF) from the degraded image data constitutes an important first step in image restoration that is known as blur identification. Though a number of blur identification algorithms have been developed in recent years, two of the earlier methods based on the power spectrum and power cepstrum remain popular, because they are easy to implement and have proved to be effective in practical situations. Both methods are limited to PSF\u27s which exhibit spectral nulls, such as due to defocused lens and linear motion blur. Another limitation of these methods is the degradation of their performance in the presence of observation noise. The central slice of the power bispectrum has been employed as an alternative to the power spectrum which can suppress the effects of additive Gaussian noise. In this paper, we utilize the bicepstrum for the identification of linear motion and defocus blurs. We present simulation results where the performance of the blur identification methods based on the spectrum, the cepstrum, the bispectrum and the bicepstrum is compared for different blur sizes and signal-to-noise ratio levels

Real-time video annotation using MPEG-7 motion activity descriptors

The MPEG-7 standard provides a framework of standardized tools that can be used to describe and efficiently manage multimedia content. Visual descriptors include color, texture, shape and motion. In this paper, we address the hardware implementation of MPEG-7 motion descriptors using Handel-C. In particular, descriptors for motion intensity and spatial distribution of motion activity are generated and implemented

Continual Domain Adaptation on Aerial Images under Gradually Degrading Weather

Domain adaptation (DA) strives to mitigate the domain gap between the source domain where a model is trained, and the target domain where the model is deployed. When a deep learning model is deployed on an aerial platform, it may face gradually degrading weather conditions during operation, leading to widening domain gaps between the training data and the encountered evaluation data. We synthesize two such gradually worsening weather conditions on real images from two existing aerial imagery datasets, generating a total of four benchmark datasets. Under the continual, or test-time adaptation setting, we evaluate three DA models on our datasets: a baseline standard DA model and two continual DA models. In such setting, the models can access only one small portion, or one batch of the target data at a time, and adaptation takes place continually, and over only one epoch of the data. The combination of the constraints of continual adaptation, and gradually deteriorating weather conditions provide the practical DA scenario for aerial deployment. Among the evaluated models, we consider both convolutional and transformer architectures for comparison. We discover stability issues during adaptation for existing buffer-fed continual DA methods, and offer gradient normalization as a simple solution to curb training instability

Semantically Invariant Text-to-Image Generation

Image captioning has demonstrated models that are capable of generating plausible text given input images or videos. Further, recent work in image generation has shown significant improvements in image quality when text is used as a prior. Our work ties these concepts together by creating an architecture that can enable bidirectional generation of images and text. We call this network Multi-Modal Vector Representation (MMVR). Along with MMVR, we propose two improvements to the text conditioned image generation. Firstly, a n-gram metric based cost function is introduced that generalizes the caption with respect to the image. Secondly, multiple semantically similar sentences are shown to help in generating better images. Qualitative and quantitative evaluations demonstrate that MMVR improves upon existing text conditioned image generation results by over 20%, while integrating visual and text modalities.Comment: 5 papers, 5 figures, Published in 2018 25th IEEE International Conference on Image Processing (ICIP