Doxycycline induced oesophageal ulcers in a navy ship crewmember

A healthy 25-year-old crewmember of a navy ship was diagnosed with suspected pneumonia and prescribed 100 mg twice a day of doxycycline for 10 days. During the 7th day of treatment the patient joined his navy ship to sail aboard and 2 days later, immediately after taking the doxycycline capsule, he felt a forceful pain in the median chest which was followed with odynophagia of both solid foods and liquids. The patient adhered to the administration guidelines of the doxycycline, except drinking 330 mL of beer, 3 h before taking the capsule. A working diagnosis of atypical chest pain, possibly due to oesophagitis, was made. The patient was advised to fast and rest and treatment with intravenously (IV) H2-receptor antagonist, clear fluids and analgesics was started. Later on, due to lack of improvement in the patient’s status and the potential risk of future deterioration, a decision was made to evacuate the patient to a hospital. Gastroscopy, revealed 3 ulcers in the mid-oesophagus and the patient was hospitalised for treated of IV antacids and fluids with gradual improvement. This case emphasizes the limitation of diagnosing and treating a common side effect in the middle of the sea and the potential risk in taking medications with alcohol

Suboptimal Choices and the Need for Experienced Individual Well-Being in Economic Analysis

Standard economic analysis assumes that people make choices that maximize their utility. Yet both popular discourse and other fields assume that people sometimes fail to make optimal choices and thus adversely affect their own happiness. Most social sciences thus frequently describe some patterns of decision as suboptimal. We review evidence of suboptimal choices that arise for two reasons. First, people err in predicting the utility they may accrue from available choice options due to the evaluation mode. Second, people choose on the basis of salient rules that are unlikely to maximize utility. Our review is meant to highlight the possibility of a research program that combines economic analysis with measures of experienced individual well-being to improve people's happiness.suboptimal choice, individual well-being, experienced utility, evaluation mode, salient rule, utility misprediction

Clustering in Hypergraphs to Minimize Average Edge Service Time

We study the problem of clustering the vertices of a weighted hypergraph such that on average the vertices of each edge can be covered by a small number of clusters. This problem has many applications such as for designing medical tests, clustering files on disk servers, and placing network services on servers. The edges of the hypergraph model groups of items that are likely to be needed together, and the optimization criteria which we use can be interpreted as the average delay (or cost) to serve the items of a typical edge. We describe and analyze algorithms for this problem for the case in which the clusters have to be disjoint and for the case where clusters can overlap. The analysis is often subtle and reveals interesting structure and invariants that one can utilize

Codes for Load Balancing in TCAMs: Size Analysis

Traffic splitting is a required functionality in networks, for example for load balancing over paths or servers, or by the source's access restrictions. The capacities of the servers (or the number of users with particular access restrictions) determine the sizes of the parts into which traffic should be split. A recent approach implements traffic splitting within the ternary content addressable memory (TCAM), which is often available in switches. It is important to reduce the amount of memory allocated for this task since TCAMs are power consuming and are often also required for other tasks such as classification and routing. Recent works suggested algorithms to compute a smallest implementation of a given partition in the longest prefix match (LPM) model. In this paper we analyze properties of such minimal representations and prove lower and upper bounds on their size. The upper bounds hold for general TCAMs, and we also prove an additional lower-bound for general TCAMs. We also analyze the expected size of a representation, for uniformly random ordered partitions. We show that the expected representation size of a random partition is at least half the size for the worst-case partition, and is linear in the number of parts and in the logarithm of the size of the address space

Statistical approach to NoC design

Chip multiprocessors (CMPs) combine increasingly many general-purpose processor cores on a single chip. These cores run several tasks with unpredictable communication needs, resulting in uncertain and often-changing traffic patterns. This unpredictability leads network-on-chip (NoC) designers to plan for the worst-case traffic patterns, and significantly over-provision link capacities. In this paper, we provide NoC designers with an alternative statistical approach. We first present the traffic-load distribution plots (T-Plots), illustrating how much capacity over-provisioning is needed to service 90%, 99%, or 100% of all traffic patterns. We prove that in the general case, plotting T-Plots is #P-complete, and therefore extremely complex. We then show how to determine the exact mean and variance of the traffic load on any edge, and use these to provide Gaussian-based models for the T-Plots, as well as guaranteed performance bounds. Finally, we use T-Plots to reduce the network power consumption by providing an efficient capacity allocation algorithm with predictable performance guarantees. © 2008 IEEE

Statistical approach to networks-on-chip

Chip multiprocessors (CMPs) combine increasingly many general-purpose processor cores on a single chip. These cores run several tasks with unpredictable communication needs, resulting in uncertain and often-changing traffic patterns. This unpredictability leads network-on-chip (NoC) designers to plan for the worst case traffic patterns, and significantly overprovision link capacities. In this paper, we provide NoC designers with an alternative statistical approach. We first present the traffic-load distribution plots (T-Plots), illustrating how much capacity overprovisioning is needed to service 90, 99, or 100 percent of all traffic patterns. We prove that in the general case, plotting T-Plots is #P-complete, and therefore extremely complex. We then show how to determine the exact mean and variance of the traffic load on any edge, and use these to provide Gaussian-based models for the T-Plots, as well as guaranteed performance bounds. We also explain how to practically approximate T-Plots using random-walk-based methods. Finally, we use T-Plots to reduce the network power consumption by providing an efficient capacity allocation algorithm with predictable performance guarantees. © 2006 IEEE

Efficient Measurement on Programmable Switches Using Probabilistic Recirculation

Programmable network switches promise flexibility and high throughput, enabling applications such as load balancing and traffic engineering. Network measurement is a fundamental building block for such applications, including tasks such as the identification of heavy hitters (largest flows) or the detection of traffic changes. However, high-throughput packet processing architectures place certain limitations on the programming model, such as restricted branching, limited capability for memory access, and a limited number of processing stages. These limitations restrict the types of measurement algorithms that can run on programmable switches. In this paper, we focus on the RMT programmable high-throughput switch architecture, and carefully examine its constraints on designing measurement algorithms. We demonstrate our findings while solving the heavy hitter problem. We introduce PRECISION, an algorithm that uses \emph{Probabilistic Recirculation} to find top flows on a programmable switch. By recirculating a small fraction of packets, PRECISION simplifies the access to stateful memory to conform with RMT limitations and achieves higher accuracy than previous heavy hitter detection algorithms that avoid recirculation. We also analyze the effect of each architectural constraint on the measurement accuracy and provide insights for measurement algorithm designers.Comment: To appear in IEEE ICNP 201

Avoiding Flow Size Overestimation in the Count-Min Sketch with Bloom Filter Constructions

The Count-Min sketch is the most popular data structure for flow size estimation, a basic measurement task required in many networks. Typically the number of potential flows is large, eliminating the possibility to maintain a counter per flow within memory of high access rate. The Count-Min sketch is probabilistic and relies on mapping each flow to multiple counters through hashing. This implies potential estimation error such that the size of a flow is overestimated when all flow counters are shared with other flows with observed traffic. Although the error in the estimation can be probabilistically bounded, many applications can benefit from accurate flow size estimation and the guarantee to completely avoid overestimation. We describe a design of the Count-Min sketch with accurate estimations whenever the number of flows with observed traffic follows a known bound, regardless of the identity of these particular flows. We make use of a concept of Bloom filters that avoid false positives and indicate the limitations of existing Bloom filter designs towards accurate size estimation. We suggest new Bloom filter constructions that allow scalability with the support for a larger number of flows and explain how these can imply the unique guarantee of accurate flow size estimation in the well known Count-Min sketch.Ori Rottenstreich was partially supported by the German-Israeli Foundation for Scientic Research and Development (GIF), by the Gordon Fund for System Engineering as well as by the Technion Hiroshi Fujiwara Cyber Security Research Center and the Israel National Cyber Directorate. Pedro Reviriego would like to acknowledge the sup-port of the ACHILLES project PID2019-104207RB-I00 and the Go2Edge network RED2018-102585-T funded by the Spanish Ministry of Science and Innovation and of the Madrid Community research project TAPIR-CM grant no. P2018/TCS-4496