Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma

Asthma is the most common chronic childhood disease in the developed nations, and is a complex disease that has high social and economic costs. Studies of the genetic etiology of asthma offer a way of improving our understanding of its pathogenesis, with the goal of improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect specific polymorphisms in genetic loci contributing to asthma susceptibility. Concomitantly, the technology for detecting single nucleotide polymorphisms (SNPs) has undergone rapid development, extensive catalogues of SNPs across the genome have been constructed, and SNPs have been increasingly used as a method of investigating the genetic etiology of complex human diseases. This paper reviews both current and potential future contributions of SNPs to our understanding of asthma pathophysiology

Saving for your future self: The role of imaginary experiences

Despite increased longevity, many people fail to save the funds necessary to support their retirement. In an attempt both to elucidate and remedy this failing, research exploring the “future-self continuity” hypothesis has revealed that temporal discounting is decreased and saving increased when connections between one’s current and future self are strengthened. Here, we explored the possibility that a basic component of mental imagery–spatial visual perspective–may be an important determinant of people’s decisions to spend now or save for the future. The results of two experiments supported this prediction. Rates of saving were enhanced when a distant-future event was generated from a third-person vs. first-person vantage point, an effect that was mediated by visual bodily awareness during mental imagery

Centrosomes as DNA damage regulators

Centrosome abnormalities are linked to genomic instability and are considered one possible cause of cancer. A recent study shows that 'abnormal' inactive centrosomes thought to be deleterious to cells actually provide an accurate backup mechanism to the G2/M checkpoint, allowing specific elimination of nuclei with damaged DNA

Virginia Coastal Master Plan

NOAA Office:OCM Duration of Use Case:Complete Link to Case:https://www.dcr.virginia.gov/crmp/plan Geographic Location: Is the Use Case Published?No Primary Use:Coastal Resiliance Which Marine Industries Benefit from the case:Ports, Coastal Infrastructure Case Benefits:The data helped the state of Virginia, it’s regional planning entities, localities, and stakeholders understand how flooding will change, and the associated risk to communities, infrastructure, natural and social receptors. The information provides a strong foundation to justify continued investments in coastal resilience to protect the quality of life and economy of Virginia communities. Description:For the development of the Virginia Coastal Resilience Master Plan, we used NOAA VDatum to provide state-wide representation of tidal elevations. Sea Level Rise scenario data were leveraged from the 2017 Global and Regional Sea Level Rise Scenarios for the United States. Long-term sea level trends from NOAA CO-OPS were used to adjust water level and sea level rise data to a common tidal epoch. Authoritative mapping products and summaries were developed depicting existing and future flood exposure to community, critical infrastructure, natural, and social systems. These were presented in both the first Coastal Master Plan document for Virginia, and the study data portal

INVOLVEMENT OF SWIMMING-INDUCED ACUTE STRESS IN THE SENSITIVITY OF RAT VAS-DEFERENS TO NOREPINEPHRINE

1. The effects of swimming-induced stress on rat sensitivity to norepinephrine were studied.2. Through microscopic analysis of the stomach from swimming stressed rats significant ulceration was observed, confirming that the stress situation was really present.3. Sensitivity to norepinephrine either in the presence or in the absence of cocaine and propranolol in acutely swimming stressed rats was not altered significantly.4. Bilateral adrenalectomy was performed in rats 2 days before swimming and acute stress resulted in a supersensitivity to norepinephrine, indicating that adrenal glands may, at least, partially mediate the sensitivity to this drug in vasa deferentia isolated from these animals

L'Orquestra Camera Musicae al Petit Palau: II cicle de concerts

Programa general del II cicle de concerts de l'Orquestra Camera Musica