265 research outputs found

    Chinese Manufacturing Performance in Comparative Perspective, 1980-2002

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    This paper uses the detailed information in the 1995 Census of Industrial Production as a benchmark for analysing the coverage, concepts and consistency of published statistical series. On the basis of the analysis, the paper proposes a series of adjustments which result in more consistent long-run series of labour productivity for 21 manufacturing sectors from 1980-2002. For purposes of international comparisons with the USA, the paper subsequently presents industry of origin unit value ratios for the benchmark year 1995. These are used to convert Chinese value added into US dollars. In 2002, value added for the statistically well-covered sectors of Chinese manufacturing was 43 per cent of US value added, against 12 per cent in 1980. The comparative analysis of labour productivity points to a long period of Chinese growth without catch up from 1980-1992. After 1992, there was a rapid and accelerating process of catch up. In comparative terms labour productivity increased from 5.3 per cent of the US level in 1995 to 13.7 per cent in 2002.China, manufacturing, productivity growth, catch up, unit value ratios, international comparisons

    Cell cycle protein expression in AIDS-related and classical Kaposi's sarcoma

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    Kaposi�s sarcoma (KS) is a peculiar vascular neoplasm that occurs mainly in elderly Mediterranean men and patients with acquired immunodeficiency syndrome (AIDS). The current literature indicates that KS is initiated by the human herpes virus 8 (HHV8) as a reactive polyclonal process but with deregulation of oncogene and tumour suppressor genes, it can progress to a true malignancy with monoclonality. Clinically, classical KS often presents as an indolent disease affecting mainly the lower extremities whereas AIDS-related KS has no site predilection and can progress rapidly with systemic involvement. Histologically, KS can be classified into patch, plaque and nodular stages. Interestingly, classical and AIDS-related KS are indistinguishable histologically and this suggests that AIDS-related KS and classical KS might be initiated by a common aetiology but given their different clinical courses, they may progress through different mechanisms. In view of the importance of the cell cycle proteins in the development and progression of many human malignancies, this thesis aims to examine the role of these proteins in the progression of the two main clinical subtypes of KS. The cell cycle protein expressions in a cohort of 47 patients with KS with welldocumented clinical and histological features were studied. Using a monclonal antibody against the latent nuclear antigen-1 molecule of HHV8, HHV8 was detected in 78% of the cases. The more advanced nodular lesions were found to have a higher level of proliferative activity as measured by the proliferation x marker, Ki-67. This suggests it is valid to use the histological specimens as a tumour progression model of KS. The role of the Rb/cyclin D1/p16 pathway was examined. The more advanced nodular stage KS lesions were more likely to be positive for cyclin D1, suggesting that cyclin D1 is important in the progression from patch stage to nodular stage. p16 acts as a tumour suppressor and it has an inhibitory effect on cyclin D1. The p16 expression rate was low in early stage KS but high in the more advanced lesions. It seems that reduced p16 expression occurs early in KS and may be important in its development. The rate of Rb expression, on the other hand, did not differ significantly among the histological subtypes. The results revealed the significant role of the Rb/cyclin D1/p16 pathway in the progression of KS. Of the mitotic cyclins examined, cyclin A expression was correlated with the advanced tumor stage. The rate of p34cdc2 expression was high in the lesions and there was no correlation with histological stage. This suggests that p34cdc2 is important in the early development of the tumour but not necessarily in its progression. Along the p53-apoptotic pathway, mutant p53 expression was significantly more common in the nodular stage. The cyclin G1 (a protooncogene, one of the target genes of p53) expression also paralleled that of mutant p53 with the majority of the KS lesions showing cyclin G1 expression and significant xi correlation between advanced histological stage and increasing rate of cyclin G1 expression. These findings suggest that progression along the p53 pathway may be important in the advanced stage development of KS. On the other hand, expression of the CDK inhibitor, p27, a protein that normally negatively regulates cyclin G1, was reduced in nodular KS. These findings suggest that some KS lesions may progress through a deregulated or abnormal p53 pathway. There were correlations between cyclin D1, cyclin A, cyclin G1, mutant p53 and negative HIV status. The findings suggest that components of both the Rb/cyclin D1/p16 and p53-apoptotic pathways are important in the progression of classical KS. Rb protein was the only cell cycle protein whose rate of expression correlated significantly with HHV8 status in KS. The majority of HHV8 positive lesions were also positive for Rb protein, unlike HHV8 negative lesions. This suggests that some of the HHV8 negative lesions can progress through a defective Rb pathway whereas the role of Rb in the progression may not be as important in the HHV8 positive lesions. This was an unexpected finding given that one of the postulated mechanisms of tumour initiation by the HHV8 virus is via the viral cyclin it produces. The viral cyclin produced by HHV8 acts through the Rb pathway much the same as cyclin D1 and one would have expected that HHV8 positive cases are less likely to be positive for the Rb protein. In summary, the majority of the KS lesions examined in this thesis show HHV8 infection. The Rb/cyclin D1/p16 pathway appears to be important in the progression of the different stages of KS and expression of the proteins involved in the p53 pathway were found to be important in the advanced stages of the development of KS. There were differential expressions of cell cycle proteins between AIDS-related and classical KS, and between HHV8 positive and HHV8 negative lesions. The findings also provided some clues to the possible mechanisms of development in KS lesions that were not initiated by HHV8

    Evidence of Convective Redistribution of Carbon Monoxide in Aura Tropospheric Emission Sounder (TES) and Microwave Limb Sounder (MLS) Observations

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    Vertical convective transport is a key element of the tropospheric circulation. Convection lofts air from the boundary layer into the free troposphere, allowing surface emissions to travel much further, and altering the rate of chemical processes such as ozone production. This study uses satellite observations to focus on the convective transport of CO from the boundary layer to the mid and upper troposphere. Our hypothesis is that strong convection associated with high rain rate regions leads to a correlation between mid level and upper level CO amounts. We first test this hypothesis using the Global Modeling Initiative (GMI) chemistry and transport model. We find the correlation is robust and increases as the precipitation rate (the strength of convection) increases. We next examine three years of CO profiles from the Tropospheric Emission Sounder (TES) and Microwave Limb Sounder (MLS) instruments aboard EOS Aura. Rain rates are taken from the Tropical Rainfall Measuring Mission (TRMM) 3B-42 multi-satellite product. Again we find a correlation between mid-level and upper tropospheric CO, which increases with rain rate. Our result shows the critical importance of tropical convection in coupling vertical levels of the troposphere in the transport of trace gases. The effect is seen most clearly in strong convective regions such as the Inter-tropical Convergence Zone

    The Kaesong North-South Korean industrial complex

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    This purpose of this report is to provide an overview of the role, purposes, and results of the Kaesong Industrial Complex (KIC) in the Democratic People's Republic of Korea (DPRK or North Korea) and examine U.S. interests, policy issues, options, and legislation

    Bioenergetic, reproductive, and population-level effects of dissolved copper and cadmium on the grass shrimp, Palaemonetes pugio

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    The grass shrimp, Palaemonetes pugio, was exposed to dissolved copper or cadmium in a series of laboratory experiments to determine effects on bioenergetics, reproduction, and population growth. In 14-day exposures, adults were exposed to either copper or cadmium to quantify bioenergetic effects. Both metals caused a decline in oxygen consumption (lowest observed effects concentrations [LOECs] = 7.5 μg Cu sup 2+/L and 6.6 μg Cd sup 2+L) and growth rate (LOECs = 27 μg Cu sup 2+/L and 6.2 μg Cd sup 2+/L). Effects of copper on growth were more severe than those of cadmium, resulting in weight loss during the exposure. Reductions in oxygen consumption and growth, in combination with declines in reproduction observed in longer exposures, suggest that both copper and cadmium reduce energy allocation to respiration and production pathways. In eight-month exposures, P. pugio were exposed to either copper or cadmium for a full life cycle, allowing larvae to attain maturation and reproduce. While survival was little affected by exposure to cadmium, brood size and the percentage of ovigerous females were significantly reduced (LOECs = 1.5 and 2.5 μg Cd sup 2+/L, respectively). Population growth of P. pugio exposed to cadmium was projected using a stage-based matrix model and a z-transformed life cycle graph analysis. Both models projected a decrease in population growth rate (LOEC = 1.5 μg Cd sup 2+/L), although population growth remained positive. Decomposition analysis indicated that cadmium-induced declines in population growth could be attributed mainly to contributions from reproductive effects. In the eight-month exposure to copper, no lethal effects on larvae, juveniles, or adults were observed, but larval development was significantly delayed (LOEC = 9 μg Cu sup 2+/L). Upon reaching maturation, females exposed to copper were able to produce embryos, but the embryos did not hatch, precluding completion of the life cycle (LOEC = 9 μg Cu sup 2+/L). The results from subsequent experiments, which further examined reproductive effects, suggested that copper may inhibit larval recruitment via a combination of effects on hatching success, parental bioenergetics, and processes before or during spawning and/or fertilization. In conclusion, both copper and cadmium may have negative impacts on the sustainability of natural populations of P. pugio in contaminated habitats

    Chinese Manufacturing Performance in Comparative Perspective, 1980-2002

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    Projected Regional Climate in 2025 Due to Urban Growth

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    By 2025, 60 to 80 percent of the world s population will live in urban environments. Additionally, the following facts published by the United Nations further illustrates how cities will evolve in the future. Urban areas in the developing world are growing very rapidly. The urban growth rate will continue to be particularly rapid in the urban areas of less developed regions, averaging 2.4 per cent per year during 2000-2030, consistent with a doubling time of 29 years. The urbanization process will continue worldwide. The concentration of population in cities is expected to continue so that, by 2030, 84 percent of the inhabitants of more developed countries will be urban dwellers. Urbanization impacts the whole hierarchy of human settlements. In 2000,24.8 per cent of the world population lived in urban settlements with fewer than 500,000 inhabitants and by 2015 that proportion will likely rise to 27.1 per cent
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