Pharmacological and therapeutical basis of torsades de pointes

Torsades de pointes (TdP) is a specific form of polymorphic ventricular tachycardia, which is a dreadful condition, severity varies from mild asymptomatic condition to severe life threatening state. In this review, i would like to highlight the physiological, pathological and pharmacological causes, prevention and management of torsades de pointes. In this present world of therapeutic jungle, due to wide spread use of medication (poly pharmacy), there is a reasonable chance of getting drug interactions resulting in prolonged QTc interval leading to tosades de pointes. The main aim of this study is to bring awareness about risk of developing torsades de pointes in patients receiving multiple drugs and also to make clinicians and pharmacologists little more cautious while prescribing drugs

Idiopathic total leukonychia involving fingernails: A report of two cases

Total leukonychia is a rare nail disorder that may be inherited or associated with systemic disease or idiopathic where the aetiology cannot be established. Herein, we report idiopathic total leukonychia in two young healthy men, presenting with leukonychia of fingernails since childhood. The cause for leukonychia could not be established in both of them as there was negative family and drug history and there was no evidence of systemic disease

Sulfolane Mediated Highly Selective Synthesis of Mono and Bis-aryl-2-Methyl-6-Fluoro-Indoles and Their Halogenated Synthons

A simple, efficient, and cheap strategy has been developed for N-arylation of indoles with hexafloro benzene (1) via incorporating sulfolane as an eco-friendly solvent. N-Monopentafluoroarylindole (3) at ambient conditions and N, N-bistetrafluomaryl indole (4) at elevated temperatures were conveniently obtained by simple nucleophilic substitution using NaOH as the base and sulfolane as a reaction medium to obtain in moderately good yields, respectively. Subsequently, 3-chloro, 3-bromo, and 3-iodomono-pentafluoroarylindoles and 3, 3'-dichloro, 3, 3'-dibromo and 3, 3'-dilodobistetrafluoroaryl indoles were prepared in good yields by using respective halogenating reagents and solvents. All the chemical transformations were confirmed by analytical tools such as 1HNMR, FR-IR and HRMS analysis

Pharmacological and therapeutical basis of torsades de pointes

Torsades de pointes (TdP) is a specific form of polymorphic ventricular tachycardia, which is a dreadful condition, severity varies from mild asymptomatic condition to severe life threatening state. In this review, i would like to highlight the physiological, pathological and pharmacological causes, prevention and management of torsades de pointes. In this present world of therapeutic jungle, due to wide spread use of medication (poly pharmacy), there is a reasonable chance of getting drug interactions resulting in prolonged QTc interval leading to tosades de pointes. The main aim of this study is to bring awareness about risk of developing torsades de pointes in patients receiving multiple drugs and also to make clinicians and pharmacologists little more cautious while prescribing drugs. [Int J Basic Clin Pharmacol 2016; 5(4.000): 1159-1163

A CASE OF SUBCUTANEOUS PHAEOHYPHOMYCOSIS CAUSED BY EXSEROHILUM SPECIES IN AN IMMUNOCOMPROMISED PATIENT

Phaeohyphomycoses are rare fungal infections, caused by dematiaceous fungi, manifested as cutaneous and subcutaneous infections, meningitis, sinusitis, keratitis, osteomyelitis and disseminated infection. This is a case report of a 45year old immuno compromised female on ART (Anti Retroviral therapy) presented with fever and generalized nodular lesions draining pus on face, hands, axilla, groin and labia majora since one month. Biopsy of the subcutaneous nodule on the lateral aspect of the thigh revealed septate fungal hyphae on 10% KOH (10% Potassium Hydroxide) mount. Fungal culture of the biopsy material on SDA (Sabouraud’s Dextrose Agar) at 250C showed cotton wooly, dark gray to olivaceous black growth with black reverse and identified as dematiaceous fungi belonging to Exserohilum species by microscopy. The patient was put on Itraconazole 200mg BD in combination with Terbinafine 250mg BD for which she responded with healing of pustular lesions in two weeks and complete remission in two months.

Amelanotic melanoma in the vicinity of acquired melanocytic nevi and not arising from agminated melanocytic nevi: Masquerading as pyogenic granuloma

Amelanotic melanoma (AMM) presenting as pyogenic granuloma and occurring in the vicinity of acquired melanocytic nevi is rare. Herein, we report such a manifestation in a 68-year-old male who presented with the painful red nodule and multiple pigmented patches involving the left great toe. Histopathological examination of skin biopsy taken from the nodule with an immunohistochemical study using HMB45 and S-100 confirmed the diagnosis of AMM. Biopsy from the pigmented patch near the nodule showed features of melanocytic nevus. Investigative work up revealed metastatic deposits in the left inguinal lymph node with no evidence of systemic involvement, placing him in malignant melanoma Stage IIIC of American Joint Committee on Cancer (AJCC) tumor node metastasis system. The development of AMM in the vicinity of acquired melanocytic nevi and manifesting as granuloma pyogenicum is unique in this case