Geochemical dispersion of tin in marine sediments, Mount's Bay, Cornwall

Imperial Users onl

Exploring ‘Expose -a-thons’:Using an 'EXPOSition marATHON' as a way of connecting student projects with local cultural organisations

For over 40 years, The Science Shops of the University of Groningen connect socially relevant questions from non-profit organisationsto research by students. In order to keep reinventing ourselves as a valuable part of the university, I would like to introduce an interactive and challenging activity called: Expose-a-thon

Closing the gap? Twitter as an instrument for connected representation

In this chapter, we present a typology of the tweeting behaviour of candidates as a means of analysing the extent to which politicians are harnessing the potential of social media to actively interact with their constituents. Our research, which included content analysis of tweets (n = 13,637) from all the Conservative and Labour tweeting candidates during the 2010 U.K. General Election, focused on four aspects of tweets: type (normal post, interaction, retweet, retweet with comment); interaction (with, e.g. a politician, journalist, citizen); function (e.g. updating, promoting, advice giving, debating); and topic. Additionally, a qualitative reading on the use of personal tweets was carried out. By examining candidates’ tweeting behaviour, we show that British politicians still mainly use Twitter as a unidirectional form of communication. They are neglecting the possibility this social network offers for, what we call, connected representation

Effect of erythropoietin on mercury-induced nephrotoxicity: Role of membrane transporters

Mercury is a widespread pollutant. Mercuric ions uptake into tubular cells is supported by the Organic anion transporter 1 (Oat1) and 3 (Oat3) and its elimination into urine is through the Multidrug resistance-associated protein 2 (Mrp2). We investigated the effect of recombinant human erythropoietin (Epo) on renal function and on renal expression of Oat1, Oat3, and Mrp2 in a model of mercuric chloride (HgCl2)- induced renal damage. Four experimental groups of adult male Wistar rats were used: Control, Epo, HgCl2, and Epo+HgCl2. Epo (3000 IU/kg, b.w., i.p) was administered 24 h before HgCl2 (4 mg/kg, b.w., i.p). Experiments were performed 18 h after the HgCl2 dose. Parameters of renal function and structure were evaluated. The protein expression of Oat1, Oat3 and Mrp2 in renal tissue was assessed by immunoblotting techniques. Mercury levels were determined by cold vapour atomic absorption spectrometry. Pretreatment with Epo ameliorated the HgCl2-induced tubular injury as assessed by histopathology and urinary biomarkers. Immunoblotting showed that pretreatment with Epo regulated the renal expression of mercury transporters in a way to decrease mercury content in the kidney. Epo pretreatment ameliorates HgCl2-induced renal tubular injury by modulation of mercury transporters expression in the kidneys.Fil: Hazelhoff, Maria Herminia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Torres, Adriana Monica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentin

Color transformation for improved traffic sign detection

This paper considers large scale traffic sign detection on a dataset consisting of high-resolution street-level panoramic photographs. Traffic signs are automatically detected and classified with a set of state-of-the-art algorithms. We introduce a color transformation to extend a Histogram of Oriented Gradients (HOG) based detection algorithm to further improve the performance. This transformation uses a specific set of reference colors that aligns with traffic sign characteristics, and measures the distance of each pixel to these reference colors. This results in an improved consistency on the gradients at the outer edge of the traffic sign. In an experiment with 33, 400 panoramic images, the number of misdetections decreased by 53.6% and 51.4% for red/blue circular signs, and by 19.6% and 28.4% for yellow speed bump signs, measured at a realistic detector operating point

Organic anion transporter 5 renal expression and urinary excretion in rats with vascular calcification

It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in an experimental model of vascular calcification in comparison with traditional markers of renal injury. Vascular calcification was obtained by the administration of an overdose of vitamin D3 (300,000 IU/kg, b.w., i.m.) to male Wistar rats. Oat5 urinary abundance was evaluated by Western blotting. Traditional markers of renal injury, such as creatinine and urea plasma levels, urinary protein levels, and urinary alkaline phosphatase (AP) activity, were determined using commercial kits. Histology was assessed by hematoxylin/eosin staining. Oat5 renal expression was evaluated by Western blotting and by immunohistochemistry. An increased expression of Oat5 in renal homogenates, in apical membranes, and in its urinary excretion was observed in rats with vascular calcification. The traditional parameters used to evaluate renal function were not modified, with the exception of histology. It is possible to postulate the urinary excretion of Oat5 as a potential noninvasive biomarker of renal injury associated with vascular calcification.Fil: Hazelhoff, Maria Herminia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bulacio, Romina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Torres, Adriana Monica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Visual transients reveal the veridical position of a moving object

The position of a moving object is often mislocalised in the direction of movement. At the input stage of visual processing, the position of a moving object should still be represented veridically, whereas it should become closer to the mislocalised position at a later processing stage responsible for positional judgment. Here, we show that visual transients expose the veridical position of a moving object represented in early visual areas. For example, when a ring is flashed on a moving bar, the part of the bar within the ring is perceived at the veridical position, whereas the part outside the ring is perceived to be ahead of the ring as in the flash-lag effect. Our observations suggest that a filling-in process is triggered at the edges of the flash. This indicates that, in early cortical areas, moving objects are still represented at their veridical positions, and the perceived location is determined by the higher visual areas