456 research outputs found
Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease
Objective
To assess the effects of l-dopa and deep brain stimulation of the subthalamic nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).
Methods
Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their âmed-offâ (OFF) and âmed-onâ (ON) status, whereas 20 DBS-STN treated patients were assessed in their âmed-off, stim-offâ (OFF) and âmed-off, stim-onâ (ON) status.
Results
In all PD patients the saccades in the OFF status were delayed, slower and smaller (p<0.01) than in controls. In pharmacologically treated patients all studied parameters showed tendency to worsen in the ON status as compared to the OFF status. In contrast, activating DBS-STN showed tendency to improve all studied parameters. Comparison of the studied saccade parameters between the ON status of DBS-STN treated patients, ON status of the pharmacologically treated patients and the controls showed that 73% of these parameters in the DBS-STN treated patients were similar as in the controls. While in the pharmacologically treated patients only 26% of these parameters were similar as in the controls.
Conclusion
This prospective study comparing the influence of l-dopa and DBS-STN on saccades in advanced PD showed contrasting results between these two treatments; the majority of the studied parameters in patients on DBS-STN were similar as in the controls
Opposite effects of l-dopa and DBS-STN on saccadic eye movements in advanced Parkinson's disease
Objective: To assess the effects of L-dopa and deep brain stimulation of the subthalamic
nucleus (DBS-STN) on saccadic eye movements in patients with Parkinson's disease (PD).
Methods: Visually and internally guided horizontal saccades were evaluated using a saccadometer in 64 patients with advanced PD and 48 healthy controls. Forty-four pharmacologically treated patients were assessed in their ââmed-offââ (OFF) and ââmed-onââ (ON) status,
whereas 20 DBS-STN treated patients were assessed in their ââmed-off, stim-offââ (OFF) and
ââmed-off, stim-onââ (ON) status.
Results: In all PD patients the saccades in the OFF status were delayed, slower and smaller
( p < 0.01) than in controls. In pharmacologically treated patients all studied parameters
showed tendency to worsen in the ON status as compared to the OFF status. In contrast,
activating DBS-STN showed tendency to improve all studied parameters. Comparison of the
studied saccade parameters between the ON status of DBS-STN treated patients, ON status
of the pharmacologically treated patients and the controls showed that 73% of these
parameters in the DBS-STN treated patients were similar as in the controls. While in the
pharmacologically treated patients only 26% of these parameters were similar as in the
controls.
Conclusion: This prospective study comparing the influence of L-dopa and DBS-STN on
saccades in advanced PD showed contrasting results between these two treatments; the
majority of the studied parameters in patients on DBS-STN were similar as in the controls
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