Effects of fatty acids upon LDL catabolism in cultured cells

Imperial Users onl

Wrongful Death Damages in Pennsylvania: A Suggestion for Expanded Recovery

Wrongful death damages in Pennsylvania are limited to pecuniary losses only. The author examines the history of this rule and the reasons why it is outdated. The author suggests that Pennsylvania law should be changed to conform with that of the majority of states to include compensation for emotional losses such as loss of companionship and society

VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM

Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only to further understand the disease but also to provide a method with which to test novel therapeutics. This study quantified the volumetric growth of a human medulloblastoma (VC312) in the athymic nude mouse cerebellum using Gd- enhanced T1-weighed MRI scans. Additionally, a medulloblastoma flank tumor model was used to explore the in vivo effect of the oral anti-cancer agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway. In the orthotopic intracerebellar tumor model, perifosine significantly increased the survival of treated mice while qualitatively reducing leptomeningeal dissemination. In the flank model, perifosine effectively suppressed the volumetric growth, decreased activation of the AKT pathway and reduced cellular proliferation in treated mice

The Contribution of Entrepreneurship Training Towards Perceived Emancipation Amongst Nascent Rural Female Entrepreneurs in Uganda

Although the number of female entrepreneurs in Uganda is increasing, they still lack appropriate entrepreneurship training and access to resources for the efficient running of their entrepreneurial activities. Furthermore, the promotion of rural female entrepreneurship in Uganda is a critical strategy in the creation of businesses and the improvement of the household income for rural female entrepreneurs. This offers them greater levels of independence and a reduced reliance on governmental social support. However, relatively little is known regarding the impact of entrepreneurship training on perceived emancipation of rural female entrepreneurs in Uganda. In this thesis, mixed methods were used to gather data. Firstly, data based on a survey of 298 nascent rural female entrepreneurs was gathered on three separate occasions: (I) Before entrepreneurship training was delivered; (II) Immediately after the entrepreneurship training was delivered, and, (III) Four months after the entrepreneurship training had finished. Secondly, qualitative analysis of the data provided additional information on the perspectives of nascent rural female entrepreneurs and their experiences four months after the training programme. The key finding of this thesis reveals that entrepreneurship training improves the business knowledge, competence and perceived emancipation of female entrepreneurs in rural Uganda. The results also found that on average, the total business knowledge and perceived emancipation scores of these female entrepreneurs, increased immediately following training programme and in the four months after the training programme finished. An overall contribution of this study is that this advancement in knowledge and perceived emancipation for rural female entrepreneurs, may assist in improving female entrepreneurial activities throughout Uganda by informing the appropriate policies

Twenty-Five Years of Dynamic Tension: The Parkdale Community Legal Services Experience

Parkdale Community Legal Services has been the site of initiatives, challenges, and historic accomplishments in the areas of community-based poverty law, community organizing and law reform, and clinical legal education. In this article, the author takes the occasion of the clinic\u27s twenty-fifth anniversary to consider some of the events and issues that shaped Parkdale\u27s history. Drawing on a range of sources, including evaluations and reports, student writing, and scholarly publications, the author examines the issues and debates that PCLS has sparked at Osgoode Hall Law School, and some of the ground it has broken more generally in its work. The history of Parkdale Community Legal Services is analyzed in relation to four areas: a) the place of clinical education in a law school; b) the place of legal education in a community legal clinic; c) the reconceptualization of clinical legal education in a poverty-law-clinic context; and d) the contribution of Pas to poverty law theory, practice, and law reform

Wysko Investment Company v. Great American Bank: A New Attack on the Usefulness of Letters of Credit

The letter of credit has long been accepted as a valuable instrument of assured payment in international business. In Wysko Investment v. Great American Bank, however, an Arizona district court jeopardized the usefulness of the letter of credit transaction by enjoining payment to the beneficiary after the issuing party became insolvent.\u27 This note addresses the issue of whether a bankruptcy court has the power to enjoin payment of a letter of credit issued by the debtor\u27s principal, pursuant to 11 U.S.C. § 105(a), when the court finds the injunction necessary for the debtor\u27s reorganization. Further, this note examines whether such an injunction represents an unreasonable burden on letters of credit as commercial devices. Although a valid argument can be made that the bankruptcy court has the power to issue this injunction, the Wysko decision represents an unreasonable expansion of the equitable powers of the bankruptcy court and an exception to the respect for the independence principle historically afforded to letters of credit by other courts. The policies behind the Wysko decision, if followed, will have a significant chilling effect on the uses of letters of credit

Wysko Investment Company v. Great American Bank: A New Attack on the Usefulness of Letters of Credit

The letter of credit has long been accepted as a valuable instrument of assured payment in international business. In Wysko Investment v. Great American Bank, however, an Arizona district court jeopardized the usefulness of the letter of credit transaction by enjoining payment to the beneficiary after the issuing party became insolvent.\u27 This note addresses the issue of whether a bankruptcy court has the power to enjoin payment of a letter of credit issued by the debtor\u27s principal, pursuant to 11 U.S.C. § 105(a), when the court finds the injunction necessary for the debtor\u27s reorganization. Further, this note examines whether such an injunction represents an unreasonable burden on letters of credit as commercial devices. Although a valid argument can be made that the bankruptcy court has the power to issue this injunction, the Wysko decision represents an unreasonable expansion of the equitable powers of the bankruptcy court and an exception to the respect for the independence principle historically afforded to letters of credit by other courts. The policies behind the Wysko decision, if followed, will have a significant chilling effect on the uses of letters of credit

Legal Forms, Family Forms, Gender Norms: What is a Spouse?

The limits of the normative nature of law may be illustrated in the current English Canadian context by apparently contradictory phenomena: Legal defeats of welfare mothers (e.g. Masse and Falkiner), and the legal victories of lesbian mothers (Re K). Drawing upon Fine, this paper employs the analytic frame of form and content to analyse contradictions within the legal form, notably in respect of the definition of spouse and the regulation of relations of property and poverty, and the struggles of lesbian parents who have applied to the courts to formalize their relationships to their children by way of adoption, and who, in so doing, have challenged the normative content of spousal relations. In analysing law as a gendering strategy, it is necessary to be mindful that law may not be the dominant site through and in which gender relations are constructed, regulated, reconstructed, or resisted. In this paper, the author examines and analyzes the contradictions in the legal form that have been mobilized, the \u27stirring up\u27 of the content that has been done, and the constraints and limits that shape the results

Twenty-Five Years of Dynamic Tension: The Parkdale Community Legal Services Experience

Parkdale Community Legal Services has been the site of initiatives, challenges, and historic accomplishments in the areas of community-based poverty law, community organizing and law reform, and clinical legal education. In this article, the author takes the occasion of the clinic\u27s twenty-fifth anniversary to consider some of the events and issues that shaped Parkdale\u27s history. Drawing on a range of sources, including evaluations and reports, student writing, and scholarly publications, the author examines the issues and debates that PCLS has sparked at Osgoode Hall Law School, and some of the ground it has broken more generally in its work. The history of Parkdale Community Legal Services is analyzed in relation to four areas: a) the place of clinical education in a law school; b) the place of legal education in a community legal clinic; c) the reconceptualization of clinical legal education in a poverty-law-clinic context; and d) the contribution of Pas to poverty law theory, practice, and law reform

Paradise Lost, Paradox Revisited: The Implications of Familial Ideology for Feminist, Lesbian, and Gay Engagement to Law

In this article the author addresses the theoretical and political challenges issued to feminists and feminist scholarship by recent debates and litigation concerning family and family-based benefits. The argument proceeds in four parts: first, the discussion is relocated within socialist feminist theory. The implications of the qualified pro-family stance in the critiques advanced or influenced by women of colour is considered next, followed by an examination of some proposals to extend the definition of spouse and family to lesbian and gay relationships. The author is critical of both critiques and illustrates with reference to Canadian welfare and immigration law that feminists, lesbians, and gays must be attentive to the complex and contradictory implications of family-based strategies