84,708 research outputs found

    Collagenous bone matrix-induced endochondral ossification hemopoiesis.

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    Transplantation of collagenous matrix from the rat diaphyseal bone to subcutaneous sites resulted in new bone formation by an endochondral sequence. Functional bone marrow develops within the newly formed ossicle. On day 1, the implanted matrix was a discrete conglomerate with fibrin clot and polymorphonuclear leukocytes. By day 3, the leukocytes disappeared, and this event was followed by migration and close apposition of fibroblast cell surface to the collagenous matrix. This initial matrix-membrane interaction culminated in differentiation of fibroblasts to chondroblasts and osteoblasts. The calcification of the hypertrophied chondrocytes and new bone formation were correlated with increased alkaline phosphatase activity and 45Ca incorporation. The ingrowth of capillaries on day 9 resulted in chondrolysis and osteogenesis. Further remodelling of bony trabeculae by osteoclasts resulted in an ossicle of cancellous bone. This was followed by emergence of extravascular islands of hemocytoblasts and their differentiation into functional bone marrow with erythropoietic and granulopoietic elements and megakaryocytes in the ossicle. The onset and maintenance of erythropoiesis in the induced bone marrow were monitored by 59Fe incorporation into protein-bound heme. These findings imply a role for extracellular collagenous matrix in cell differentiation

    Signature of a chemical bond in the conductance between two metal surfaces

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    Conductance in monatomic metal contacts is quantized; it increases in discrete steps of one conductance quantum 2e(2)/h. By contrast, in a vacuum barrier between two metal surfaces we find that conductance increases linearly and continuously with the interaction energy between individual atoms. This behavior shows unambiguously that current flow between single atoms is a measure for their chemical interaction. In the controlled environment of a scanning tunneling microscope it should allow us to study the formation of covalent bonds up to the point where these atoms finally jump into contact

    STRAIN-INDUCED INTERACTION ENERGIES BETWEEN HYDROGEN-ATOMS IN PALLADIUM

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    The authors have made quantitative calculations of the elastic interactions between interstitial hydrogen atoms in Pd metal. These calculations use the Harwell HADES code, and hence go beyond the usual harmonic models. Results have been obtained for several potentials and, where appropriate, agree well with those of previous workers. They find (i) that the absolute values are sensitive to assumptions for the potentials, suggesting caution in the prediction of thermodynamic properties, and (ii) that there are significant few-body terms not included in the usual approaches. These extra terms affect the equilibrium structure, for example by removing the symmetry between fractional occupancies theta and (1- theta ), and may lead to the initial nucleation of metastable structures during hydrogenation. The present results suggest that corner-sharing tetrahedra are favoured

    Falling chains

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    The one-dimensional fall of a folded chain with one end suspended from a rigid support and a chain falling from a resting heap on a table is studied. Because their Lagrangians contain no explicit time dependence, the falling chains are conservative systems. Their equations of motion are shown to contain a term that enforces energy conservation when masses are transferred between subchains. We show that Cayley's 1857 energy nonconserving solution for a chain falling from a resting heap is incorrect because it neglects the energy gained when a transferred link leaves a subchain. The maximum chain tension measured by Calkin and March for the falling folded chain is given a simple if rough interpretation. Other aspects of this falling folded chain are briefly discussed.Comment: 9 pages, 1 figure; the Abstract has been shortened, three paragraphs have been re-written for greater clarity, and textual improvements have been made throughout the paper; to be published by the Am. J. Physic

    Land, Poverty and Human Development in Kenya

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    The question of poverty has become central to the work of development economists in the last decade and a half. The 2000 World Development Report was entitled Attacking Poverty and the UN held a series of World Conferences in the 1990s, all of which addressed in some form or fashion the problem of poverty. Despite this and because of limited data there has been relatively little empirical work at the household level on determinants of poverty in Africa generally and Kenya specifically. In the few econometric studies that have been done for Kenya land has not been a significant determinant of poverty. This is a surprising result for a country where 80 per cent of the population depends on agriculture. Further the little that has been done has not incorporated the role of human development in the determination of poverty. Via an examination of a nationwide sample this paper will examine the role that land and social capital play in determining households poverty status in rural Kenya in addition to the standard theorized determinants. JEL Categories: O150, Q150Poverty, Rural, Land, Kenya, Africa, Human Development
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