Supplementary Material for: Three-Year Clinical Outcome of Patients with Coronary Disease and Increased Event Risk Treated with Newer-Generation Drug-Eluting Stents: From the Randomized DUTCH PEERS Trial

<p><b><i>Objective:</i></b> Limited data is available on the long-term outcome of patients with increased cardiovascular event risk, treated with newer-generation durable polymer drug-eluting stents (DES). <b><i>Methods:</i></b> We therefore assessed 3-year follow-up data of high-risk versus low- to intermediate-risk patients of the randomized DUTCH PEERS trial (NCT01331707). In both risk groups we also compared patients treated with Resolute Integrity versus Promus Element DES. Patients were categorized as “high-risk” if they met ≥1 of the following criteria: (1) diabetes (17.9%); (2) previous myocardial infarction (21.9%); (3) previous coronary revascularization (25.8%); (4) chronic renal failure (3.5%); (5) left ventricular ejection fraction ≤30% (1.5%); and (6) age ≥75 years (17.3%). <b><i>Results:</i></b> At the 3-year follow-up, the incidence of the composite endpoint target vessel failure (TVF) (13.2 vs. 7.5%; logrank <i>p</i> < 0.001) and 2 of its components - cardiac death (4.7 vs. 1.5%; logrank <i>p</i> < 0.001) and target vessel revascularization (7.3 vs. 4.7%; logrank <i>p</i> = 0.03) - was higher in high-risk (<i>n</i> = 957) versus low- to intermediate-risk patients (<i>n</i> = 854). Among high-risk patients, treatment with Resolute Integrity (<i>n</i> = 481) and Promus Element stents (<i>n</i> = 476) was similarly safe and efficacious (TVF: 13.3 vs. 13.1%; logrank <i>p</i> = 0.95; definite-or-probable stent thrombosis: 1.7 vs. 1.7%; logrank <i>p</i> = 1.00). <b><i>Conclusions:</i></b> The newer-generation Resolute Integrity and Promus Element stents showed similar results in terms of safety and efficacy for treating high-risk patients, who had significantly higher event rates than patients with low-to-intermediate risk.</p