Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide.

The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism. To determine the effect of GHRP on human somatotroph cells in vitro, we stimulated cell cultures derived from 12 different human somatotroph adenomas with GHRP alone and in combination with GH-releasing hormone (GHRH), TRH, and the somatostatin analog octreotide. GH secretion of all 12 adenoma cultures could be stimulated with GHRP, whereas GHRH was active only in 6 adenoma cultures. In GHRH-responsive cell cultures, simultaneous application of GHRH and GHRP had an additive effect on GH secretion. TRH stimulated GH release in 4 of 7 adenoma cultures; in TRH-responsive cell cultures there was also an additive effect of GHRP and TRH on GH secretion. In 5 of 9 adenoma cultures investigated, octreotide inhibited basal GH secretion. In these cell cultures, GHRP-induced GH release was suppressed by octreotide. In 5 of 5 cases, the protein kinase-C inhibitor phloretin partly inhibited GHRP-stimulated GH release, but not basal GH secretion. In summary, GH secretion was stimulated by GHRP in all somatotroph adenomas investigated, indicating that its unknown receptor and signaling pathway are expressed more consistently in somatotroph adenoma cells than those for GHRH, TRH, and somatostatin. Our data give further evidence that GHRP-stimulated GH secretion is mediated by a receptor different from that for GHRH or TRH, respectively, and that protein kinase-C is involved in the signal transduction pathway. Because human somatotroph adenoma cell cultures respond differently to various neuropeptides (GHRH, TRH, somatostatin, and others), they provide a model for further investigation of the mechanism of action of GHRP-induced GH secretion

Anisotropic Exchange in LiCu2O2{\bf LiCu_2O_2}

We investigate the magnetic properties of the multiferroic quantum-spin system LiCu$_2$O$_2$ by electron spin resonance (ESR) measurements at $X$- and $Q$-band frequencies in a wide temperature range $(T_{\rm N1} \leq T \leq 300$\,K). The observed anisotropies of the $g$ tensor and the ESR linewidth in untwinned single crystals result from the crystal-electric field and from local exchange geometries acting on the magnetic Cu$^{2+}$ ions in the zigzag-ladder like structure of LiCu$_2$O$_2$. Supported by a microscopic analysis of the exchange paths involved, we show that both the symmetric anisotropic exchange interaction and the antisymmetric Dzyaloshinskii-Moriya interaction provide the dominant spin-spin relaxation channels in this material.Comment: 10 pages, 10 Figure

Testing connections between exo-atmospheres and their host stars: GEMINI-N/GMOS ground-based transmission spectrum of Qatar-1b

Till date, only a handful exo-atmospheres have been well characterized, mostly by means of the transit method. Some classic examples are HD 209458b, HD 189733b, GJ-436b, and GJ-1214b. Data show exoplanet atmospheres to be diverse. However, this is based on a small number of cases. Here we focus our study on the exo-atmosphere of Qatar-1b, an exoplanet that looks much like HD 189733b regarding its host star's activity level, their surface gravity, scale height, equilibrium temperature and transit parameters. Thus, our motivation relied on carrying out a comparative study of their atmospheres, and assess if these are regulated by their environment. In this work we present one primary transit of Qatar-1b obtained during September, 2014, using the 8.1 m GEMINI North telescope. The observations were performed using the GMOS-N instrument in multi-object spectroscopic mode. We collected fluxes of Qatar-1 and six more reference stars, covering the wavelength range between 460 and 746 nm. The achieved photometric precision of 0.18 parts-per-thousand in the white light curve, at a cadence of 165 s, makes this one of the most precise datasets obtained from the ground. We created 12 chromatic transit light curves that we computed by integrating fluxes in wavelength bins of different sizes, ranging between 3.5 and 20 nm. Although the data are of excellent quality, the wavelength coverage and the precision of the transmission spectrum are not sufficient to neither rule out or to favor classic atmospheric models. Nonetheless, simple statistical analysis favors the clear atmosphere scenario. A larger wavelength coverage or space-based data is required to characterize the constituents of Qatar-1b's atmosphere and to compare it to the well known HD 189733b. On top of the similarities of the orbital and physical parameters of both exoplanets, from a long Hα photometric follow-up of Qatar-1, presented in this work, we find Qatar-1 to be as active as HD 189733.Facultad de Ciencias Astronómicas y GeofísicasInstituto de Astrofísica de La Plat

Spin dynamics of the ordered phase of the frustrated antiferromagnet ZnCr2O4: a magnetic resonance study

We present an elaborate electron-spin resonance study of the low-energy dynamics and magnetization in the ordered phase of the frustrated spinel ZnCr2O4. We observe several resonance modes corresponding to different structural domains and found that the number of domains can be easily reduced by field-cooling the sample through the transition point. To describe the observed antiferromagnetic resonance spectra it is necessary to take into account an orthorhombic lattice distortion in addition to the earlier reported tetragonal distortion which both appear at the antiferromagnetic phase transition

Evidence for electronically-driven ferroelectricity in the family of strongly correlated dimerized BEDT-TTF molecular conductors

By applying measurements of the dielectric constants and relative length changes to the dimerized molecular conductor $\kappa$-(BEDT-TTF)$_2$Hg(SCN)$_2$Cl, we provide evidence for order-disorder type electronic ferroelectricity which is driven by charge order within the (BEDT-TTF)$_2$ dimers and stabilized by a coupling to the anions. According to our density functional theory calculations, this material is characterized by a moderate strength of dimerization. This system thus bridges the gap between strongly dimerized materials, often approximated as dimer-Mott systems at 1/2 filling, and non- or weakly dimerized systems at 1/4 filling exhibiting charge order. Our results indicate that intra-dimer charge degrees of freedom are of particular importance in correlated $\kappa$-(BEDT-TTF)$_2$X salts and can create novel states, such as electronically-driven multiferroicity or charge-order-induced quasi-1D spin liquids.Comment: 6 pages, 4 figures + Supplementary Information (8 pages, 8 figures

Investigating the ranges of (meta)stable phase formation in (In_xGa_1−x)₂O₃: Impact of the cation coordination

We investigate the phase diagram of the heterostructural solid solution (InxGa1−x)2O3 both computationally, by combining cluster expansion and density functional theory, and experimentally, by means of transmission electron microscopy (TEM) measurements of pulsed laser deposited (PLD) heteroepitaxial thin films. The shapes of the Gibbs free energy curves for the monoclinic, hexagonal, and cubic bixbyite alloy as a function of composition can be explained in terms of the preferred cation coordination environments of indium and gallium. We show by atomically resolved scanning TEM that the strong preference of indium for sixfold coordination results in ordered monoclinic and hexagonal lattices. This ordering impacts the configurational entropy in the solid solution and thereby the (InxGa1−x)2O3 phase diagram. The resulting phase diagram is characterized by very limited solubilities of gallium and indium in the monoclinic, hexagonal, and cubic ground state phases, respectively, but exhibits wide metastable ranges at realistic growth temperatures. On the indium rich side of the phase diagram a wide miscibility gap up to temperatures higher than 1400 K is found, which results in phase separated layers. The experimentally observed indium solubilities in the PLD samples are in the range of x=0.45 and x=0.55 for monoclinic and hexagonal single-phase films, while for phase separated films we find x=0.5 for the monoclinic phase, x=0.65–0.7 for the hexagonal phase and x≥0.9 for the cubic phase. These values are consistent with the computed metastable ranges for each phase

Boundary and expansion effects on two-pion correlation functions in relativistic heavy-ion collisions

We examine the effects that a confining boundary together with hydrodynamical expansion play on two-pion distributions in relativistic heavy-ion collisions. We show that the effects arise from the introduction of further correlations due both to collective motion and the system's finite size. As is well known, the former leads to a reduction in the apparent source radius with increasing average pair momentum K. However, for small K, the presence of the boundary leads to a decrease of the apparent source radius with decreasing K. These two competing effects produce a maximum for the effective source radius as a function of K.Comment: 6 pages, 5 Eps figures, uses RevTeX and epsfi

Scaling of hadronic transverse momenta in a hydrodynamic treatment of relativistic heavy ion collisions

The transverse momenta of hadrons in central nucleus-nucleus collisions are evaluated in a boost invariant hydrodynamics with transverse expansion. Quark gluon plasma is assumed to be formed in the initial state which expands and cools via a first order phase transition to a rich hadronic matter and ultimately undergoes a freeze-out. The average transverse momentum of pions, kaons, and protons is estimated for a wide range of multiplicity densities and transverse sizes of the system. For a given system it is found to scale with the square-root of the particle rapidity density per unit transverse area, and consistent with the corresponding values seen in $p\overline{p}$ experiments at 1800 GeV, suggesting a universal behaviour. The average transverse momentum shows only an approximate scaling with multiplicity density per nucleon which is at variance with the $p\overline{p}$ data.Comment: 6 pages including 9 figure