A sound-producing voice prosthesis

Mahieu, H.F. [Promotor]Festen, J.M. [Copromotor]Verdonck-de Leeuw, I.M. [Copromotor

Neuroendocrine neoplasms of the middle ear: unpredictable tumor behavior and tendency for recurrence

Background Middle ear adenomatous neuroendocrine tumors (MEANTs) are rare temporal bone tumors. This study evaluates its clinical behavior and therapy outcome.Method Retrospective case review in a tertiary referral center evaluating histopathology, immunohistochemistry, treatment, and outcome.Results Nine patients were diagnosed with MEANT. One patient presented with locally invasive tumor and underwent extensive en-bloc tumor resection with adjuvant radiotherapy. Seven of eight patients with locally non-aggressive tumor confined to the tympanomastoid space underwent tumor resection. Two patients were disease-free, five presented recurrence, even after apparent successful surgery. All tumors showed neuroendocrine features. Histopathology and immunohistochemistry did not yield prognostic tumor characteristics.Conclusion MEANTs are rare tumors with uncertain biological behavior and subsequent unpredictable clinical course. The preferred treatment is complete surgical tumor resection. They have a high tendency for recurrence, irrespective of negative intermediary surgery. As of yet, there are no prognostic biomarkers, including histopathology and immunohistochemistry.Otorhinolaryngolog

The Relation Between Histological, Tumor-Biological and Clinical Parameters in Deep and Superficial Leiomyosarcoma and Leiomyoma

Purpose: Leiomyosarcomas (LMS) of deep and superficial tissues were examined to identify prognostic markers explaining their different biological behaviour and to define differences between cutaneous and subcutaneous LMS. LMS and leiomyomas (LM) of the skin were compared to and consistent differences that could aid in the (sometimes difficult) diagnosis

Does heart rate influence CMR image quality of the coronary vessel wall?

Cardiolog

Cardiac magnetic resonance imaging analysis in STEMI: quantitative or still visual?

Cardiovascular Aspects of Radiolog

Evaluation of pulmonary arterial hypertension: invasive or noninvasive?

Vascular Biology and Interventio

Stress imaging in patients with diabetes; routine practice?

Ventricular Dysfunction & Heart Failur

Assessment of left ventricular function: visual or quantitative?

Cardiovascular Aspects of Radiolog

Use of the anterior-posterior chest diameter in CT: reduction in radiation dose?

Vascular Biology and Interventio

100 kV versus 120 kV: effective reduction in radiation dose?

Atherosclerosi