Mitochondrial failure in sepsis:acute mechanisms and long-term consequences

Sepsis is defined as a dysregulated host response to infection, which can lead to loss of organ homeostasis and multiple organ failure. Mortality and morbidity associated with sepsis and septic shock are high. Sepsis causes one in five of all global deaths, which equals about 11 million deaths per year. Health problems and death rates after surviving sepsis also remain high. Despite years of research, little is known about the exact cause of organ failure in sepsis and treatment remains limited to antibiotics and supportive care. Mitochondria have emerged as key players in the pathogenesis of organ failure in sepsis. In this thesis, we explored the role of mitochondria in the induction of organ failure in sepsis. We found that sepsis leads to mitochondrial DNA damage, as can be measured in plasma and in the kidney. In addition, oxidative damage during sepsis is associated with long-term mortality and kidney failure. Experiments in cells and mice revealed that administration of hydrogen sulfide (H2S) protects mitochondria in cells and mice during sepsis, and lowers inflammation and kidney damage in mice. Further unravelling the role of mitochondria in sepsis can aid the development of novel therapies to improve mitochondrial function with major relevance to the health and life span of patients with sepsis

WHEELCHAIR MOBILITY PERFORMANCE ONLY SUPPORTS THE USE OF TWO CLASSES IN WHEELCHAIR BASKETBALL

The purpose of this study was to determine the effect of functional classification on wheelchair mobility performance in wheelchair basketball, measured during match play (n=29) and a standardised field test (n=47). In unconstrained field test conditions, wheelchair mobility performance outcomes only differed significantly between the low classified players compared to the adjacent higher class athletes. In match play differences between adjacent classes are less prominent, with a more even rise in performance with increase in classification. These differences in patterns were expected to be the consequence of match related factors, field position in particular. Differentiated wheelchair mobility performance measurement on and off court could corroborate classification guidelines or provide bases for a reduced number of classes

Diagnostiek en behandeling van stress incontinence bij de vrouw

Hoofdstuk 1. Na een korte inleiding over de ontwikkeling van het normale hart wordt gewezen op het grote belang van de bulbus cordis en de truncus arteriosus voor het ontstaan van de afwijkingen, zoals ze bij de verschillende vormen van pulmonaalstenose gevonden worden. Over de oorzaak van het ontstaan van de aangeboren hartgebreken is weinig met zekerheid bekend. De patiënten met een pulmonaalstenose kunnen in twee grote groepen verdeeld worden: in degenen, waarbij het septum ventriculorum niet gesloten is en in de patiënten, bij wie dit wel het geval is. ... Zie: Samenvatting

Diagnostiek en behandeling van stress incontinence bij de vrouw

Hoofdstuk 1. Na een korte inleiding over de ontwikkeling van het normale hart wordt gewezen op het grote belang van de bulbus cordis en de truncus arteriosus voor het ontstaan van de afwijkingen, zoals ze bij de verschillende vormen van pulmonaalstenose gevonden worden. Over de oorzaak van het ontstaan van de aangeboren hartgebreken is weinig met zekerheid bekend. De patiënten met een pulmonaalstenose kunnen in twee grote groepen verdeeld worden: in degenen, waarbij het septum ventriculorum niet gesloten is en in de patiënten, bij wie dit wel het geval is. ... Zie: Samenvatting

NEW METHODS FOR MOBILITY PERFORMANCE MEASUREMENT IN WHEELCHAIR BASKETBALL

Increased professionalism in wheelchair sports demand a more precise and quantitative measure of individual wheelchair mobility performance, to allow it to be an evaluation measure of wheelchair setting or training optimization. This research describes the application of an inertial sensor based method for measuring wheelchair kinematics and a factor analysis based selection of outcomes best describing wheelchair mobility performance. This set of kinematic outcomes was analysed for sensitivity towards wheelchair performance differences due to competition level and classification of the match data of 29 wheelchair basketball athletes. The method proved sensitive and is believed to provide a solid basis for a kinematics based definition of wheelchair mobility performance in sports

Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities

Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so does the number of sepsis survivors who suffer from "post-sepsis syndrome" after hospital discharge. This syndrome involves deficits in multiple systems, including the immune, cognitive, psychiatric, cardiovascular, and renal systems. Combined, these detrimental consequences lead to rehospitalizations, poorer quality of life, and increased mortality. Understanding the pathophysiology of these issues is crucial to develop new therapeutic opportunities to improve survival rate and quality of life of sepsis survivors. Such novel strategies include modulating the immune system and addressing mitochondrial dysfunction. A sepsis follow-up clinic may be useful to identify long-term health issues associated with post-sepsis syndrome and evaluate existing and novel strategies to improve the lives of sepsis survivors. (C) 2020 The Author(s). Published by Elsevier B.V

SPEED PROFILES IN WHEELCHAIR COURT SPORTS; COMPARISON OF TWO METHODS FOR MEASURING WHEELCHAIR MOBILITY PERFORMANCE

Wheelchair mobility performance is an important aspect in most wheelchair court sports, commonly measured with an indoor tracking system or wheelchair bound inertial sensors. Both methods provide key performance outcomes regarding speed. In this study, we compared speed profiles of both methods to gain insight in the level of agreement. Data were obtained from 5 players during 6x 10 min. of wheelchair basketball match play. Both systems provide similar outcomes regarding distance covered and average speed. Due to differences in sample frequency and reference position on the wheelchair (for speed calculation), minor differences show at low speeds (\u3c2.5 m/s). Since both systems provide complementary features, a hybrid solution as proved feasible in this study, could possibly serve as the new standard for mobility performance measurement in court sports

Speed profiles in wheelchair court sports; comparison of two methods for measuring wheelchair mobility performance

Wheelchair mobility performance is an important aspect in most wheelchair court sports, commonly measured with an indoor tracking system or wheelchair bound inertial sensors. Both methods provide key wheelchair mobility performance outcomes regarding speed. In this study, we compared speed profiles of both methods to gain insight into the level of agreement, for recommendations regarding future performance measurement. Data were obtained from 5 male highly trained wheelchair basketball players during match play. Players were equipped simultaneously with a tag on the footplate for the indoor tracking system (~8 Hz) and inertial sensors on both wheels and frame (199.8 Hz). Being part of a larger study on 3 vs 3 player game formats, data were collected in several matches with varying field sizes, but activity profiles closely resembled regular match play. Both systems provide similar outcomes regarding distance covered and average speed. Due to differences in sampling frequency and sensor location (reference point) on the wheelchair (for speed calculation), minor differences were revealed at low speeds (<2.5 m/s). Since both systems provide complementary features, a hybrid solution as proved feasible in this study, could possibly serve as the new gold standard for mobility performance measurement in wheelchair basketball or wheelchair court sports in general