Gait deviations in children with cerebral palsy : a modeling approach

Lankhorst, G.J. [Promotor]Harlaar, J. [Copromotor]Doorenbosch, C.A.M. [Copromotor

'Typical of the New Zealand Occupational Distribution'?: A Reconsideration of Catholic Interwar Employment Patterns

During the 1920s and 1930s, New Zealand Catholics often characterised themselves as a relatively poor community, and mostly engaged in low paid, unskilled employment. In the 1970s, reflecting on the Church fifty years earlier, historian Ernest Simmons claimed that Catholics tried to explain their relative lack of social and career advancement by blaming the Masons and other opponents and by creating 'a myth that Catholics had always been poor'. In his seminal 1990 work on the Irish in New Zealand, Donald Akenson attempted to debunk this myth, declaring that 'the dead centre normality of Irish Catholics is striking' and that they were 'typical of the New Zealand occupational distribution'

Customizing learning programs to the organization and its emplyees:How HRD practitioners create tailored learning programs

This study investigates how HRD practitioners customise learning programs, that is, tailor them to take into account the demands set by organisation and participants. A theoretical account of the relations between learning programmes and organisational/individual characteristics is provided. Results from an action-research project involving 13 learning programmes conducted in healthcare institutions are presented. The main conclusion of the study is that the seven HRD practitioners in our sample used few strategies to customise learning programmes

Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling

The vasculature is characterized by a thin cell layer that comprises the inner wall of all blood vessels, the continuous endothelium. Endothelial cells can also be found in the eye's cornea. And even though cornea and vascular endothelial (VE) cells differ from each other in structure, they both function as barriers and express similar junctional proteins such as the adherens junction VE-cadherin and tight-junction member claudin-5. How these barriers are controlled to maintain the barrier and thereby its integrity is of major interest in the development of potential therapeutic targets. An important target of endothelial barrier remodeling is the actin cytoskeleton, which is centrally coordinated by Rho GTPases that are in turn regulated by Rho-regulatory proteins. In this review, we give a brief overview of how Rho-regulatory proteins themselves are spatiotemporally regulated during the process of endothelial barrier remodeling. Additionally, we propose a roadmap for the comprehensive dissection of the Rho GTPase signaling network in its entirety