Strategizing as multi-modal and rhetorical discursive practice: a case study of the BHP Billiton's failed acquisition of Rio Tinto

This thesis took a discourse approach to analyze BHP Billiton’s failed acquisition of Rio Tinto in 2007-08 to better understand what happens during strategizing. The research highlighted the structure and dynamics of the discourse, as well as the role of time and context in the social construction of meaning in strategizing. In doing so, the thesis provided new insights into how actors were able to influence such important strategic events. The thesis adopted a multi-modal discourse analytic framework and analyzed media reports, corporate videos, press releases and communications to shareholders, as well as slides and full transcripts of key presentations by both BHP and Rio leadership. The analysis identified the main internal and external actors as either decision-makers (BHP’s leadership, shareholders, competition regulators) or influencers (Rio’s leadership, analysts, media, customers). It further identified a range of multi-modal discursive practices and rhetorical strategies that were brought to bear to negotiate the meaning of three key constructs that shaped the discourse, that is, the additional value pool, the fair share exchange ratio, and the impact on competition. Further, the findings showed how time and context were discursively constructed and influenced the meaning of the three key constructs. These findings enabled a number of contributions to the discourse and M&A literature. While most research into acquisition discourses has routinely ignored the pre-acquisition discourse, this thesis focused on the period preceding the transaction. An initial contribution was to show that, in a pre-acquisition discourse, external actors were not a passive audience but played a significant role as rhetor and audience. Also, while previous empirical studies of discourse have emphasized the role of language, this thesis considered multi-modal discursive practices, including speech, writing, imagery, location and calculative devices. The thesis made a further contribution by showing how actors worked to persuade each other through multi-layered rhetorical strategies that were also brought to bear through non-linguistic modes. This contribution was extended by showing how these practices functioned as transgression markers that signaled convergence or divergence of meaning of the key constructs. A detailed analysis of calculative devices enabled further contributions. An initial contribution was that it showed how calculative devices developed as boundary objects over four stages: identification, calculation, negotiation, and objectification. Further, the thesis showed how calculative devices were imbued with logos and ethos through, for example, the calculative logic, accounting standards and data sources that were woven together in the symbolic manipulations of the device. Lastly, the thesis showed how calculative devices acted as boundary objects, and made a contribution to theory by proposing a third criterion, legitimacy, to complement widely acknowledged criteria of adaptability and commonality. In addition to these dynamics, the thesis outlined a discursive epistemology of strategizing through its analysis of the role of time and context in the social construction of meaning in strategizing. While the role of time and context is widely acknowledged in organizational discourse, it remained unclear what was specific to strategizing. The thesis argued that the purpose of strategizing is to construct and negotiate new or improved options for a preferred future and the actions to bring this about, and made a contribution to a discursive epistemology of strategizing by showing how temporal and contextual work in strategizing extends the horizon of discourses that relate to the future and discourses that relate to the broader discourse. This reconstructs the tapestry of interwoven discourses that make up the local strategy discourse, and creates new strategic options

Studies on breeding dwarf poinsettias (Euphorbia pulcherrima Willd.) and the influence of infective agents

BACKGROUND: Hypoxia, metabolism, and growth factor signaling are important prognostic features in most solid tumors. The purpose of this study was to determine whether head and neck squamous cell carcinoma (HNSCC) xenografts show similar biological and molecular characteristics as the primary tumor they originate from. METHODS: Eighteen HNSCC primary tumor-xenograft pairs were immunofluorescently stained for pimonidazole (hypoxia), carbonic anhydrase IX (CAIX), glucose transporter-1 (GLUT-1), monocarboxylate transporter-1 (MCT-1), monocarboxylate transporter-4 (MCT-4), epidermal growth factor receptor (EGFR), and phosphorylated protein kinase B (pAKT). RESULTS: Although no correlation was found for the amount of hypoxia, significant correlations between primary tumors and xenografts were observed for both the percentage of cells positive for expression and the hypoxia-related expression pattern of CAIX, GLUT-1, and MCT-1. For EGFR and MCT-4, the intensity of expression was correlated. No correlation was observed for pAKT. CONCLUSION: Xenografts did not always resemble the primary tumor they originate from, but the xenografts did represent the variability in expression levels and patterns observed in the primary tumors

A prospective methicillin resistant staphylococcus aureus typing system for infection control : design and effectiveness

The uptake of Gadomer-17, as probed by fast dynamic T(1) measurements, was used to assess the vascular permeability surface-area product per leakage volume of tissue (k(Tofts)) of human glioma xenografts implanted in mice. With this approach we could discriminate between two types of glioma xenograft lines with a known difference in the perfused vascular architecture and degree of hypoxia. The T(1) data were analyzed according to the Tofts-Kermode compartment model. The fast-growing E102 tumor demonstrated a homogeneous distribution of the vascular permeability surface area across the tumor (mean k(Tofts) value = 0.18 +/- 0.05 min(-1)). The slowly growing E106 tumor showed a more heterogeneous pattern. Three perfused tumor areas with differences in vascular permeability surface area could be distinguished: a well-perfused periphery with high k(Tofts) values (0.24 +/- 0.04 min(-1)), perfused capillaries inside the tumor with low k(Tofts) values (0.108 +/- 0.026 min(-1)), and perfused capillaries adjacent to necrotic regions with high k(Tofts) values (0.29 +/- 0.10 min(-1)). On a different series of tumors, the hypoxic fractions were measured, and these were significantly higher in E106 tumors (0.14 +/- 0.05) compared to tumors of the E102 line (0.03 +/- 0.02)

Genome editing poses ethical problems that we cannot ignore

The ability to precisely and accurately change almost any part of any genome, even in complex species such as humans, may soon become a reality through genome editing. But with great power comes great responsibility – and few subjects elicit such heated debates about moral rights and wrongs. Although genetic engineering techniques have been around for some time, genome editing can achieve this with lower error rates, more simply and cheaply than ever – although the technology is certainly not yet perfect. Genome editing offers a greater degree of control and precision in how specific DNA sequences are changed. It could be used in basic science, for human health, or improvements to crops. There are a variety of techniques but clustered regularly inter-spaced short palindromic repeats, or CRISPR, is perhaps the foremost. CRISPR has prompted recent calls for a genome editing moratorium from a group of concerned US academics. Because it is the easiest technique to set up and so could be quickly and widely adopted, the fear is that it may be put into use far too soon – outstripping our understanding of its safety implications and preventing any opportunity to think about how such powerful tools should be controlled. Ethical concerns over genetic modification are not new, particularly when it comes to humans. While we don’t think genome editing gives rise to any completely new ethical concerns, there is more to gene editing than just genetic modification..

Time-dose relationships for spinal cord damage

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Modification of the early and late delayed radiation response of the rat spinal cord by chemotherapeutic agents

Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-

Stralingsschade in normale weefsels

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Honderd jaar radiologie in Nederland, IX : klinische radiobiologie

Contains fulltext : 22204___.PDF (publisher's version ) (Open Access

Vascularisatie en doorbloeding van tumoren als doelwit voor kankertherapie.

Contains fulltext : 25179___.PDF (publisher's version ) (Open Access