The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring : a systematic review and meta-analysis

Funding One author (CJ) was funded by the Ministry of Health, Government of Sri Lanka. Availability of data and materials Supporting data can be obtained from the corresponding author.Peer reviewedPublisher PD

Evaluation of technology-enhanced learning programs for health care professionals: systematic review

Background: Technology-enhanced learning (TEL) programs are increasingly seen as the way in which education for health care professionals can be transformed, giving access to effective ongoing learning and training even where time or geographical barriers exist. Given the increasing emphasis on this mode of educational support for health care practitioners, it is vital that we can effectively evaluate and measure impact to ensure that TEL programs are effective and fit for purpose. This paper examines the current evidence base for the first time, in relation to the evaluation of TEL programs for health care professionals. Objective: We conducted a systematic review of the current literature relating to the evaluation of TEL programs for health care professionals and critically appraised the quality of the studies. Methods: This review employed specific search criteria to identify research studies that included evaluation of TEL for health care professionals. The databases searched included Medline Ovid, Cumulative Index of Nursing and Allied Health Literature Plus Advanced, Applied Social Sciences Index and Abstracts, ZETOC, Institute of Electrical and Electronics Engineers Explore Digital Library, Allied and Complementary Medicine, and Education Resources Information Center between January 2006 and January 2017. An additional hand search for relevant articles from reference lists was undertaken. Each of the studies identified was critically appraised for quality using the Crowe Critical Appraisal Tool. This approach produced a percentage total score for each study across specified categories. A proportion of the studies were independently assessed by an additional two reviewers. Results: The review identified 21 studies that met the inclusion criteria. The studies included scored totals across eight categories within a range of 37%-95% and an average score of 68%. Studies that measured TEL using learner satisfaction surveys, or combined pretest and posttest knowledge score testing with learner satisfaction surveys, were found to be the most common types of TEL evaluations evident in the literature. The studies reviewed had low scores across reporting on ethical matters, design, and data collection categories. Conclusions: There continues to be a need to develop effective and standard TEL evaluation tools, and good quality studies that describe effective evaluation of TEL education for health care professionals. Studies often fail to provide sufficient detail to support transferability or direct future TEL health care education programs

βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedPeer reviewe

MATCHED ARCHITECTURES FOR SIGNAL PROCESSING AND CONTROL

Fast processing environments for real-time data acquisition, data processing and control applications may be realised using very different architectures. State of the art systems generally employ multiprocessors and parallel processing having a dedicated architecture such as systolic arrays to support computation-intensive signal processing tasks such as, for instance, convolution, filtering, FFT. etc. Mostly, general purpose rather than application driven architectures are used whenever possible and the available literature is heavily concentrated on the first configuration. At TPD-TNO, the research emphasis is on application driven architectures. and the objectives for the so-called 'matched' architecture designs are: - Capability for a wide range of sizes, starting from small systems. The objective here is design for scalability - Design for systems to be used in harsh environments - Design for minimum connectivity. reduced communication bandwidth, incorporation of dedicated preprocessing. multibus systems, etc. The real-time behaviour of general purpose architectures is not sufficiently predictable and they are not designed to perform acquisition tasks or data-intensive processing with high performance. Matched architectures, on the contrary, are designed for well defined applications and optimized for each application, The key effort in matched architecture research is directed towards efficiently mapping algorithms to processing steps in hardware (and software) architectures. Essentially. the design process is iterative

Head-mounted virtual reality and mental health: critical review of current research

Background: eHealth interventions are becoming increasingly used in public health, with virtual reality (VR) being one of the most exciting recent developments. VR consists of a three-dimensional, computer-generated environment viewed through a head-mounted display. This medium has provided new possibilities to adapt problematic behaviors that affect mental health. VR is no longer unaffordable for individuals, and with mobile phone technology being able to track movements and project images through mobile head-mounted devices, VR is now a mobile tool that can be used at work, home, or on the move. Objective: In line with recent advances in technology, in this review, we aimed to critically assess the current state of research surrounding mental health. Methods: We compiled a table of 82 studies that made use of head-mounted devices in their interventions. Results: Our review demonstrated that VR is effective in provoking realistic reactions to feared stimuli, particularly for anxiety; moreover, it proved that the immersive nature of VR is an ideal fit for the management of pain. However, the lack of studies surrounding depression and stress highlight the literature gaps that still exist. Conclusions: Virtual environments that promote positive stimuli combined with health knowledge could prove to be a valuable tool for public health and mental health. The current state of research highlights the importance of the nature and content of VR interventions for improved mental health. While future research should look to incorporate more mobile forms of VR, a more rigorous reporting of VR and computer hardware and software may help us understand the relationship (if any) between increased specifications and the efficacy of treatment

Lophomonas blattarum and bronchopulmonary disease

The natural habitat of the multiflagellate protozoon Lophomonas blattarum is as an endocommensal in the hindgut of insects such as cockroaches. However, it also causes bronchopulmonary disease in humans. The aim of this paper was to review the literature on this organism in the context of respiratory disease. The biology epidemiology, route of transmission, pathogenic mechanisms and diagnosis methods are also described. A total of 61 cases were identified in the literature. The majority of these reports were from China, with some cases from Peru and Spain. Most cases were adult males, although paediatric cases were reported in Peru. Clinical presentation was non-specific, including symptoms such as fever, cough and breathless. Antiprotozoal therapy was generally effective

Bestemmingsplan buitengebied 2010, gemeente Cuijk, Toetsingsadvies over het milieueffectrapport

De Gemeente Cuijk wil een nieuw bestemmingsplan buitengebied vaststellen. Hierin worden groei van veehouderijen en nieuwe recreatieve ontwikkelingen mogelijk gemaakt. Omdat dit bestemmingsplan kaderstellend is voor toekomstige m.e.r.-(beoordelings)plichtige activiteiten (intensieve veehouderij) en omdat mogelijk een passende beoordeling volgens de Natuurbeschermingswet 1998 moet worden opgesteld, is voor dit bestemmingsplan een planm. e.r.-procedure doorlopen. Bevoegd gezag voor deze m.e.r.-procedure is de gemeenteraad van Cuijk

A Chandra Observation of the Nearby Lenticular Galaxy NGC 5102: Where are the X-ray Binaries?

We present results from a 34 ks Chandra/ACIS-S observation of the nearby (d=3.1 Mpc) lenticular galaxy NGC 5102, previously shown to have an unusually low X-ray luminosity. We detect eleven X-ray point sources within the the $D_{25}$ optical boundary of the galaxy (93% of the light), one third to one half of which are likely to be background AGN. One source is coincident with the optical nucleus and may be a low-luminosity AGN. Only two sources with an X-ray luminosity greater than 10$^{37}$ ergs s$^{-1}$ in the 0.5-5.0 keV band were detected, one of which is statistically likely to be a background AGN. We expected to detect 6 such luminous sources if the XRB population scales linearly with optical magnitude of the host galaxy. NGC 5102 has an unusually low number of XRBs. NGC 5102 is unusually blue for its morphological type, and has undergone at least two recent bursts of star formation. We present the results of optical/UV spectral synthesis analysis and demonstrate that a significant fraction ($>$50%) of the stars in this galaxy are comparatively young ($<3\times10^9$ years old). If the lack of X-ray binaries is related to the relative youth of most of the stars, this would support models of LMXB formation and evolution that require wide binaries to shed angular momentum on a timescale of Gyrs. We find that NGC 5102 has an unusually low specific frequency of globular clusters ($S_N\sim$0.4), which could also explain the lack of LMXBs. We also detect diffuse X-ray emission in the central $\sim$1 kpc of the galaxy. This hot gas is most likely a superbubble created by multiple supernovae of massive stars born during the most recent star burst, and is driving the shock into the ISM which was inferred from optical observations.Comment: 33 pages, 7 figures, 6 tables - Accepted for publication in the Astrophysical Journa

Improving the mental health of farmers: what types of remote support are acceptable, feasible, and improve outcomes? A feasibility RCT

Background: The farming community have high rates of poor mental health, and are relatively ‘hard to reach’ with mental health services. The aim of this study was therefore to undertake a feasibility RCT, based on two mental health interventions. These were (1) CBT based ‘Living Life to the Full for Farming Communities’ (LLTTF-F; www.llttf.com), and (2) a holistic social and emotional support service delivered by the Royal Scottish Agricultural Benevolent Institution (RSABI). The feasibility was supplemented by process evaluation. Methods: This feasibility study aimed to recruit 40 individuals from the farming community who were experiencing a common health problem defined as a score of &gt; = 8 on PHQ-9. A snowball approach was used to recruit interested individuals who had an association with farming. An initial telephone call screened for eligibility and obtained consent to randomisation to the two specified interventions, or to a thirdly group receiving a combination of both LLTTF-F and ‘Social and emotional support’. Participants were permitted to override the randomised option if they expressed a strong preference before the interventions began. Results: Thirty-two participants provided baseline and three-month data. All three interventions showed positive improvements on PHQ-9 scores as follows: the ‘combined intervention’ mean baseline score was 18.1 compared to 12.0 at 3-month follow-up (mean change 6.1). ‘Social and emotional support’ mean baseline score was 11.3 compared to 6.7 at 3-month follow-up (mean change 4.6). ‘LLTTF-F CBT-based intervention only’ mean baseline score was 11.8 compared to 4.5 at 3-month follow-up (mean change 7.3). The retention rate was 81% at three months. In a sub-group of the LLTTF-F CBT-based intervention online materials were supplemented by telephone guided support. This approach received very positive feedback. Conclusions: Recruitment from the farming community required intense effort, and good engagement can then be retained for at least three months. There is evidence that the interventions used were feasible, and tentative evidence that they had a demonstrable effect on mental wellbeing, with the LLTTFF providing the largest effect on PHQ-9 scores. Trial Registration Number ISRCTN27173711, submitted 25/08/2023, confirmed 22/092023