383 research outputs found
Schuivende panelen
Schuivende panelen was de titel van een partijprogramma uit de jaren tachtig. Deze
rede is echter geen politiek manifest. Hoewel een wetenschapper in staat moet zijn
om politiek te bedrijven en de Allergologie als discipline sinds haar oprichting speelbal
geweest is van politieke krachten gaat deze lezing vooral over verschuivingen en
ontwikkelingen in het vakgebied.
rede
In verkorte vorm uitgesproken
ter gelegenheid van het aanvaarden
van het ambt van bijzonder hoogleraar
met als leeropdracht Allergologie
aan het Erasmus MC, faculteit van de
Erasmus Universiteit Rotterdam, op 20 april 200
Positive and negative AIT trials: What makes the difference?
Background: Allergen immunotherapy has proven to be efficacious in allergic rhinitis and asthma. However, results from randomised clinical trials may vary substantially. Clinical trials may unexpectedly fail. The purpose of this review is to discuss the possible factors that may contribute to a successful or unsuccessful study. Methods: Descriptive review exploring the possible causes of negative outcomes in allergen immunotherapy trials. Results: A series of factors may lead to negative results. Among of these are underpowering of the study, low allergen content in tested extracts, insufficient allergen exposure during monitoring and recruitment of inappropriate patients. In addition, the choice of the primary endpoint may be critical. Discussion: A clinical trial aims to evaluate the efficacy of an agent. However, studies with potential effective compounds may fail because of methodical issues. Sometimes, they are the cause of discrepancies between successful phase II and unsuccessful phase III trials. To understand more about failure of studies, investigators and editors should be encouraged to publish negative trials
Legends of allergy and immunology:Anthony J. Frew—A true European advocate of allergology and clinical immunology
Comparison of nasal responsiveness to histamine, methacholine and phentolamine in allergic rhinitis patients and controls
In a selected group of rhinitis patients with an IgE‐mediated allergy to house dust mites the nasal response to insufflation of histamine chloride, methacholine and phentolamine was demonstrated to be higher than in a control group. With the methods used histamine chloride was better at discriminating between healthy subjects and patients than methacholine or phentolamine. This discrimination was shown by assessing the severity of reflex‐mediated symptoms such as the number of sneezes and the amount of secretion, and not by differences in nasal airway resistance. Copyrigh
Nasal hyperreactivity
The subject of this thesis is nasal hyperreactivity or hyperresponsiveness in allergic and
nonallergic rhinitis. Hyperreactivity represents an altered state of the upper or lower
airways, resulting in an exaggerated response to non-specific stimuli encountered in the
environment. Generally, hyperrea.ctivity is a major feature of the disease leading to
recurrent or chronic symptoms. In allergic rhinitis and asthma hyperreactivity will
reinforce the response after allergen exposure.
Although it is known that patients with allergic and non-allergic rhinitis often react with
symptoms to environmental non-specific stimuli, standardized and generally accepted
tools for measurement of nasal hyperreactivity are not available.
Many investigators demonstrated a relation between hyperreactivity of the lower airways
and IgE-mediated allergy, especially with respect to the link between hyperreactivity and
late phase allergic reactions. However, in nasal allergy a relative backlog exists
regarding insight into interactions between IgE-mediated reactions and nasal
hyperreactivityThis thesis focuses on answering two questions:
L How to measure nasal hyperreactivity ?
2. What is the role and clinical significance of nasal hyperreactivity, especially in
nasal allergy ?
After a review of the literature (part I, Chapter 2) the current methods of assessment of
nasal hyperreactivity are analysed (part II). To this end, nasal challenges with various
non-specific stimuli were performed in allergic and non-allergic rhinitis patients
compared to healthy subjects (chapters 3,4 and 5).
Subsequently the clinical aspects of hyperreactivity in nasal allergy (part III) have been
investigated. The relevance of hyperresponsiveness was analysed with respect to the
daily symptoms of the patie
Nasal allergy to avian antigens
This study describes the case of a patient who developed symptoms of rhinoconjunctivitis on exposure to budgerigars and parrots. An IgE‐mediated allergy to budgerigar, parrot and pigeon antigens was demonstrated using both in‐vivo challenge tests (skin and nasal provocation tests) and in‐vitro investigations (radio‐allergo‐sorbent test, histamine release test). The study shows that the development of nasal disease can be associated with allergy to avian antigens. Copyrigh
Legends of allergy and clinical immunology: Anthony J. Frew—A true European advocate of allergology and clinical immunology
Role of double blind placebo controlled challenge test with wheat followed by exercise in patients suspected of wheat dependant exercise induced anaphylaxis (WDEIA)
Rise in Economic Interactions in the Indian Ocean Rim : Implication for Maritime Policies in African Countrie
textabstractOne of the purposes to perform an oral food challenge (FC) test is to avoid unnecessary elimination of food allergens. In case of a negative FC test result, the food can be introduced. It is, however, unknown if patients act according to the outcome of the test. This study evaluates the rate of introduction of peanut, hazelnut, cow’s milk or hen’s egg allergens after a negative FC test. We investigated the introduction rate of children (0–18 years) with a negative FC test visiting the Department of Allergology, Erasmus Medical Centre Rotterdam from 2008 till 2013 and the factors that influence the rate of introduction. Patients wer
Skin tests, T cell responses and self-reported symptoms in children with allergic rhinitis and asthma due to house dust mite allergy
Abstract
BACKGROUND: In allergic responses, a distinction is made between an early-phase response, several minutes after allergen exposure, and a late-phase response after several hours. During the late phase, eosinophils and T cells infiltrate the mucosa and play an important role in inflammation.
OBJECTIVE: The aim of this study was to examine the relationship between allergen-induced late-phase skin responses and in vitro T cel
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